INT108805

Context Info Confidence 0.18 First Reported 2003 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.44 Pain Relevance 0.97

transmembrane transporter activity (Slc22a8) plasma membrane (Slc22a8)

Slc22a8 (Rattus norvegicus)

Pain Link Frequency Relevance Heat methotrexate 15 99.92 cINOD 8 98.20 Inflammation 1 91.00

Disease Link Frequency Relevance Heat INFLAMMATION 5 97.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, OAT3 interacted with sulfated steroid hormones such as estrone-3-sulfate.

OAT3 Binding (interacted) of

1) Confidence 0.18 Published 2003 Journal Rev. Physiol. Biochem. Pharmacol. Section Abstract Doc Link 12605306 Disease Relevance 0.17 Pain Relevance 0.17

MTX is recognized by reduced folate carrier (RFC-1) and rat organic anion transporters (rOat1 and rOat3) as a substrate.

rOat3 Binding (recognized) of associated with methotrexate

2) Confidence 0.11 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14722319 Disease Relevance 0.17 Pain Relevance 0.65

We herein propose that UST1r be renamed OA transporter 8 (rOat8). rOat8 interacted with chemically heterogenous anionic compounds, such as nonsteroidal anti-inflammatory drugs, diuretics, probenecid, taurocholate, and methotrexate, but not with the organic cation tetraethylammonium.

rOat8 Binding (interacted) of associated with inflammation, cinod and methotrexate

3) Confidence 0.00 Published 2008 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 18441515 Disease Relevance 0.10 Pain Relevance 0.14

General Comments

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