INT108810

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Context Info
Confidence 0.51
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 1.79
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Esr1, Oprm1) enzyme binding (Esr1) DNA binding (Esr1)
protein complex (Esr1) signal transducer activity (Oprm1) cytoplasm (Esr1)
Esr1 (Mus musculus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 52 100.00 Very High Very High Very High
Central nervous system 4 95.04 Very High Very High Very High
Endogenous opioid 8 90.32 High High
agonist 4 81.16 Quite High
Morphine 4 79.20 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 8 99.60 Very High Very High Very High
Lordosis 12 86.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine which estrogen receptor, estrogen receptor-alpha (ERalpha) or estrogen receptor-beta (ERbeta), mediates MOR internalization, ERalpha knockout (ERalphaKO), ERbeta knockout (ERbetaKO) and wild-type (WT) mice were used in the present study.
estrogen receptor Positive_regulation (mediates) of MOR Binding (internalization) of associated with targeted disruption and opioid receptor
1) Confidence 0.51 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12605406 Disease Relevance 0.45 Pain Relevance 0.80
To determine which estrogen receptor, estrogen receptor-alpha (ERalpha) or estrogen receptor-beta (ERbeta), mediates MOR internalization, ERalpha knockout (ERalphaKO), ERbeta knockout (ERbetaKO) and wild-type (WT) mice were used in the present study.
estrogen receptor Positive_regulation (mediates) of MOR Binding (internalization) of associated with targeted disruption and opioid receptor
2) Confidence 0.51 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12605406 Disease Relevance 0.45 Pain Relevance 0.81
To determine which estrogen receptor, estrogen receptor-alpha (ERalpha) or estrogen receptor-beta (ERbeta), mediates MOR internalization, ERalpha knockout (ERalphaKO), ERbeta knockout (ERbetaKO) and wild-type (WT) mice were used in the present study.
estrogen receptor-alpha Positive_regulation (mediates) of MOR Binding (internalization) of associated with targeted disruption and opioid receptor
3) Confidence 0.51 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12605406 Disease Relevance 0.45 Pain Relevance 0.81
To determine which estrogen receptor, estrogen receptor-alpha (ERalpha) or estrogen receptor-beta (ERbeta), mediates MOR internalization, ERalpha knockout (ERalphaKO), ERbeta knockout (ERbetaKO) and wild-type (WT) mice were used in the present study.
ERalpha Positive_regulation (mediates) of MOR Binding (internalization) of associated with targeted disruption and opioid receptor
4) Confidence 0.51 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12605406 Disease Relevance 0.45 Pain Relevance 0.80

General Comments

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