INT108813

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 2.79
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ptges) cytoplasm (Ptges)
Anatomy Link Frequency
chondrocytes 1
macrophages 1
microglia 1
Ptges (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 126 99.40 Very High Very High Very High
Paracetamol 8 98.56 Very High Very High Very High
cINOD 18 98.40 Very High Very High Very High
Potency 96 96.48 Very High Very High Very High
antagonist 18 92.96 High High
COX-2 inhibitor 6 89.40 High High
Inflammation 158 89.12 High High
Inflammatory mediators 10 87.36 High High
Analgesic 1 85.60 High High
Stimulus evoked pain 3 76.08 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 192 97.68 Very High Very High Very High
Disease 18 93.32 High High
Neurodegenerative Disease 5 89.36 High High
Apoptosis 6 84.80 Quite High
Stroke 3 79.84 Quite High
Injury 12 78.64 Quite High
Pain 15 76.08 Quite High
Hypersensitivity 3 75.68 Quite High
Brain Injury 36 75.28 Quite High
Necrosis 10 74.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paracetamol effectively reduces prostaglandin E2 synthesis in brain macrophages by inhibiting enzymatic activity of cyclooxygenase but not phospholipase and prostaglandin E synthase.
Negative_regulation (inhibiting) of prostaglandin E synthase in macrophages associated with paracetamol
1) Confidence 0.57 Published 2003 Journal J. Neurosci. Res. Section Title Doc Link 12605411 Disease Relevance 0.34 Pain Relevance 1.03
Similarly, the strong decrease in mPGES-1 mRNA (-93% versus -87%; Fig. 3b) and protein (-70% versus -65%; Fig. 3c) levels was unaffected.
Negative_regulation (decrease) of mPGES
2) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0 Pain Relevance 0.23
agonists could reduce PG synthesis by inhibiting mPGES-1 in rat chondrocytes stimulated with IL-1?.
Negative_regulation (inhibiting) of mPGES in chondrocytes associated with agonist
3) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.66 Pain Relevance 0.41
Such a mechanism would be consistent with the ability of 15d-PGJ2 to inhibit PGE2 production and to downregulate mPGES-1 in microsomal fractions from CHO cells overexpressing mPGES [26].
Negative_regulation (downregulate) of mPGES
4) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.55 Pain Relevance 0.33
M rosiglitazone increased COX-2 mRNAs by 37% and decreased mPGES-1 mRNAs by 10% (Fig. 2b), while leaving COX-2 protein unaffected and decreasing mPGES-1 protein by 36% (Fig. 2c).
Negative_regulation (decreasing) of mPGES
5) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0 Pain Relevance 0.15
-dependent inhibition of mPGES-1 [53].
Negative_regulation (inhibition) of mPGES
6) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.23 Pain Relevance 0.29
Our findings indicate for the first time that resveratrol is a potent inhibitor of PGE2 production in microglia through a mechanism that involves reduction in the expression of the key enzyme involved in PGE2 formation, namely, microsomal prostaglandin E synthase-1 (mPGES-1).
Negative_regulation (reduction) of mPGES-1 in microglia
7) Confidence 0.03 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.29 Pain Relevance 0
Next, we examined the potential effects of SC-560 and VAS on LPS-mediated mPGES-1 expression, which could help to explain if the effects of resveratrol on the reduction in mPGES-1 were mediated by a COX-1 mechanism.
Negative_regulation (reduction) of mPGES-1
8) Confidence 0.03 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.08 Pain Relevance 0.04
Thus, it is of paramount importance our finding that resveratrol specifically reduced mPGES-1 without affecting COX-2 levels.
Negative_regulation (reduced) of mPGES-1
9) Confidence 0.03 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.65 Pain Relevance 0.24
M rosiglitazone increased COX-2 mRNAs by 37% and decreased mPGES-1 mRNAs by 10% (Fig. 2b), while leaving COX-2 protein unaffected and decreasing mPGES-1 protein by 36% (Fig. 2c).
Negative_regulation (decreased) of mPGES
10) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0 Pain Relevance 0.14

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