INT108814

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 3.62
Pain Relevance 3.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGES) signal transduction (PTGES) cytoplasm (PTGES)
Anatomy Link Frequency
granulocytes 3
chondrocytes 2
phagocytes 2
monocytes 1
PTGES (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 3 99.98 Very High Very High Very High
cINOD 12 99.84 Very High Very High Very High
Osteoarthritis 132 98.76 Very High Very High Very High
rheumatoid arthritis 3 98.08 Very High Very High Very High
Inflammation 87 97.52 Very High Very High Very High
Acute pain 3 96.88 Very High Very High Very High
cytokine 15 96.28 Very High Very High Very High
Paracetamol 8 95.44 Very High Very High Very High
aspirin 1 91.88 High High
Pain 8 87.88 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 101 99.72 Very High Very High Very High
Osteoarthritis 144 98.76 Very High Very High Very High
Rheumatoid Arthritis 3 98.08 Very High Very High Very High
Fever 4 97.92 Very High Very High Very High
Pain 11 96.88 Very High Very High Very High
Neurodegenerative Disease 2 82.56 Quite High
Adhesions 3 80.08 Quite High
Arthritis 6 75.52 Quite High
Cancer 4 67.84 Quite High
Necrosis 4 67.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was designed to investigate the regulation of expression of mPGES-1 in polarized phagocytes, which represent central, cellular orchestrators of inflammatory reactions.
Spec (investigate) Regulation (regulation) of Gene_expression (expression) of mPGES-1 in phagocytes associated with inflammation
1) Confidence 0.59 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.57 Pain Relevance 0.33
SC-560 treatment neither altered TNFalpha-induced COX-2 or mPGES-1 expression nor did the addition of the calcium ionophore A23187 or arachidonic acid reverse the inhibition by SC-560.
Neg (neither) Regulation (altered) of Gene_expression (expression) of mPGES-1
2) Confidence 0.51 Published 2006 Journal FASEB J. Section Abstract Doc Link 16816110 Disease Relevance 0.23 Pain Relevance 0.28
It is interesting that early growth response-1 (Egr-1) protein, which is a key transcription factor in regulating the inducible expression of microsomal PGE synthase 1 (mPGES-1) and therefore promotes PGE2 release [40], is also significantly reduced by an HO-1 inducer, CoPP, in IL-1?
Regulation (regulating) of Gene_expression (expression) of mPGES-1
3) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.25 Pain Relevance 0.12
Cyclooxygenase 2 expression tested in the same experimental conditions was modulated in monocytes and granulocytes similarly to mPGES-1.
Regulation (modulated) of Gene_expression (expression) of mPGES-1 in granulocytes associated with cox2
4) Confidence 0.43 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.38 Pain Relevance 0.36
These data are consistent with the regulation of mPGES-1 expression by HNE at the transcription level.
Regulation (regulation) of Gene_expression (expression) of mPGES-1
5) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.22 Pain Relevance 0.18
Firstly, to determine whether changes in mPGES-1 mRNA levels can be ascribed to the regulation in promoter activity, chondrocytes were transiently transfected with human mPGES-1 promoter-luciferase reporter genes (n = 6 independent experiments) and then treated with single addition of 10 ?
Regulation (changes) of Gene_expression (levels) of mPGES-1 mRNA in chondrocytes
6) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.05 Pain Relevance 0.03
It has been shown that mPGES-1 expression is upregulated in animal models of rheumatoid arthritis and in patients suffering from OA [4,5] and is downregulated by anti-inflammatory drugs [6,7]. mPGES-1 expression is regulated by several transcription factors, such as early growth response-1 (Egr-1) and NF-?
Regulation (regulated) of Gene_expression (expression) of mPGES-1 associated with inflammation, cinod, rheumatoid arthritis and osteoarthritis
7) Confidence 0.24 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 1.05 Pain Relevance 0.63
Cyclooxygenase 2 expression tested in the same experimental conditions was modulated in monocytes and granulocytes similarly to mPGES-1.
Regulation (modulated) of in monocytes Gene_expression (expression) of mPGES-1 in granulocytes associated with cox2
8) Confidence 0.15 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.38 Pain Relevance 0.36
The drug did not affect the expression of the enzymes involved in PGE(2) synthesis, i.e., COX-1, COX-2, and microsomal PGE synthase, or the release of the precursor arachidonic acid (AA).
Neg (not) Regulation (affect) of Gene_expression (expression) of microsomal PGE synthase
9) Confidence 0.01 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12605411 Disease Relevance 0.49 Pain Relevance 1.27

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