INT10885

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Context Info
Confidence 0.38
First Reported 1986
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 11.86
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
lungs 2
horn 1
spinal cord 1
C3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 118 99.78 Very High Very High Very High
Inflammation 23 97.12 Very High Very High Very High
Central nervous system 58 95.52 Very High Very High Very High
Dorsal horn 1 93.48 High High
Immobilon 3 91.08 High High
Morphine 2 84.48 Quite High
opiate 1 75.00 Quite High
Demyelination 2 13.76 Low Low
antagonist 2 13.60 Low Low
ischemia 2 11.68 Low Low
Disease Link Frequency Relevance Heat
Cirrhosis 679 100.00 Very High Very High Very High
Bacterial Respiratory Disease 42 100.00 Very High Very High Very High
Spinal Cord Injury 140 99.32 Very High Very High Very High
Pressure And Volume Under Development 35 99.20 Very High Very High Very High
Bacterial Meningitis 301 99.12 Very High Very High Very High
INFLAMMATION 23 97.12 Very High Very High Very High
Sprains And Strains 217 95.72 Very High Very High Very High
Central Nervous System Disease 56 95.52 Very High Very High Very High
Injury 114 95.36 Very High Very High Very High
Disease 8 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study demonstrated that C3 levels are also significantly reduced in cirrhotic rats' bronchoalveolar lavage fluid.
Negative_regulation (reduced) of C3 associated with cirrhosis
1) Confidence 0.38 Published 2007 Journal BMC Microbiol Section Body Doc Link PMC2140065 Disease Relevance 1.20 Pain Relevance 0.04
Complement C3 levels in the lavage fluid from cirrhotic rats also were significantly decreased to less than half of those in control animals (1185 ng/ml vs. 2443 ng/ml; p = 0.012).


Negative_regulation (decreased) of Complement C3 associated with cirrhosis
2) Confidence 0.33 Published 2007 Journal BMC Microbiol Section Body Doc Link PMC2140065 Disease Relevance 1.29 Pain Relevance 0
This argument was strengthened by the present study demonstrating both significantly decreased levels of complement component C3 in the alveolar lining fluid of cirrhotic rats and decreased complement deposition on the surface of pneumococci recovered from their lungs after a transtracheal infection.
Negative_regulation (decreased) of complement component C3 in lungs associated with bacterial meningitis, cirrhosis and infection
3) Confidence 0.33 Published 2007 Journal BMC Microbiol Section Body Doc Link PMC2140065 Disease Relevance 1.32 Pain Relevance 0
Our laboratory and others have shown that cirrhotic hosts are often hypocomplementemic, with decreased levels of complement component C3 in their serum and ascites fluid [13,46,47].
Negative_regulation (decreased) of complement component C3 associated with pressure and volume under development and cirrhosis
4) Confidence 0.33 Published 2007 Journal BMC Microbiol Section Body Doc Link PMC2140065 Disease Relevance 1.29 Pain Relevance 0.03
To determine whether reduced pulmonary C3 levels in the cirrhotic rats corresponded to reduced complement-mediated opsonization of pneumococci within their lungs, we quantified C3 deposition on pneumococci following infection.
Spec (whether) Negative_regulation (reduced) of C3 in lungs associated with bacterial meningitis, cirrhosis and infection
5) Confidence 0.28 Published 2007 Journal BMC Microbiol Section Body Doc Link PMC2140065 Disease Relevance 1.31 Pain Relevance 0
Animals that are deficient in C3 or received neutralizing antibodies or receptors for C1q or C3 have been shown to have less inflammation after CNS injury/disease, suggesting an important role for complement in recruiting inflammatory cells to sites of injury [54-56].
Negative_regulation (deficient) of C3 associated with inflammation, injury, central nervous system and disease
6) Confidence 0.26 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 1.82 Pain Relevance 0.50
The defect in the early bactericidal activity of alveolar lining components is related, at least in part, to significantly reduced levels of the antibacterial proteins lysozyme and complement C3 in the cirrhotic rats.
Negative_regulation (reduced) of complement C3 associated with cirrhosis and bacterial respiratory disease
7) Confidence 0.24 Published 2007 Journal BMC Microbiol Section Body Doc Link PMC2140065 Disease Relevance 1.29 Pain Relevance 0
Levels of lysozyme and complement component C3 were both significantly reduced in bronchoalveolar lavage fluid from cirrhotic rats.
Negative_regulation (reduced) of complement component C3 associated with cirrhosis
8) Confidence 0.24 Published 2007 Journal BMC Microbiol Section Abstract Doc Link PMC2140065 Disease Relevance 1.65 Pain Relevance 0
In contrast with the in vitro data above that showed less than 30% of cultured PMNs were associated with C1q or C3 proteins (Figure 5), data presented here show that after 3 days following SCI, 78% or 70% of infiltrating PMNs exhibited C1q or C3 respectively, suggesting an elevated number of infiltrating PMNs synthesizing or internalizing complement proteins in the injured spinal cord.
Negative_regulation (exhibited) of C3 in spinal cord associated with spinal cord injury and spinal cord
9) Confidence 0.22 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.52 Pain Relevance 0.25
After a unilateral spinal cord lesion at C3, ChAT activity was reduced in the ipsilateral ventral horn at C6-7 caudal to the lesions, whereas no change in receptor binding sites was observed.
Negative_regulation (reduced) of C3 in horn associated with spinal cord
10) Confidence 0.21 Published 1986 Journal Acta Physiol. Scand. Section Abstract Doc Link 3012950 Disease Relevance 0 Pain Relevance 0.37
C3-hydroxylation of diazepam and nordazepam (36% of controls) and N-demethylation of erythromycin and ethylmorphine (58% and 64% of controls) were decreased in 6-week ethanol-treated animals, these effects being less pronounced in the 12, 24 and 48-week ethanol-treated groups.
Negative_regulation (decreased) of C3-hydroxylation
11) Confidence 0.02 Published 1992 Journal Alcohol Alcohol. Section Abstract Doc Link 1524605 Disease Relevance 0.16 Pain Relevance 0.16

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