INT108856

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.79
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD2) oxidoreductase activity (SOD2) aging (SOD2)
mitochondrion organization (SOD2) DNA binding (SOD2) cytoplasm (SOD2)
Anatomy Link Frequency
SH-SY5Y 2
cleavage 2
SOD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 160 97.84 Very High Very High Very High
Osteoarthritis 27 89.12 High High
cINOD 19 67.68 Quite High
Codeine 6 50.00 Quite Low
cytokine 8 28.16 Quite Low
Inflammation 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 5 97.80 Very High Very High Very High
Cancer 8 97.44 Very High Very High Very High
Injury 8 94.00 High High
Disease 6 89.44 High High
Osteoarthritis 27 89.12 High High
Apoptosis 90 76.96 Quite High
Neuroblastoma 20 50.00 Quite Low
Stress 17 24.60 Low Low
Parkinson's Disease 8 23.36 Low Low
INFLAMMATION 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[52]; furthermore, thiol-reducing agents can affect SOD2 biosynthesis, as demonstrated by the enhanced SOD2 expression caused by thioredoxin, a potent disulfide oxidoreductase [31].
Regulation (affect) of Gene_expression (biosynthesis) of SOD2
1) Confidence 0.44 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.34 Pain Relevance 0.13
The results showed a significant (P < 0.001) up-regulation of SOD2 gene expression in IL-1?
Regulation (regulation) of Gene_expression (expression) of SOD2 gene
2) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.23 Pain Relevance 0.07
To this aim, the dose- and time-dependent effects of this drug on SOD2 protein levels of SH-SY5Y cells were analysed in the experiments reported in Figure 3.
Spec (analysed) Regulation (effects) of Gene_expression (levels) of SOD2 protein in SH-SY5Y
3) Confidence 0.27 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.21 Pain Relevance 0.38
Codeinone stimulated the release of both cytochrome c and cytochrome oxidase, and cleavage of procaspase 3 without significant changes in both the activity and expression of MnSOD.
Neg (without) Regulation (changes) of Gene_expression (expression) of MnSOD in cleavage
4) Confidence 0.25 Published 2003 Journal Anesthesiology Section Body Doc Link 12606908 Disease Relevance 0 Pain Relevance 0

General Comments

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