INT108857

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.51
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD2) oxidoreductase activity (SOD2) aging (SOD2)
mitochondrion organization (SOD2) DNA binding (SOD2) cytoplasm (SOD2)
SOD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Antinociceptive 2 95.52 Very High Very High Very High
diclofenac 80 92.68 High High
Codeine 14 75.00 Quite High
Opioid 3 67.36 Quite High
Inflammation 1 46.40 Quite Low
cINOD 10 44.88 Quite Low
dexamethasone 8 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 80 99.44 Very High Very High Very High
Breast Cancer 11 99.16 Very High Very High Very High
Cancer 50 97.08 Very High Very High Very High
Prostate Cancer 13 86.56 High High
Immunotherapy Of Cancer 2 79.72 Quite High
Skin Cancer 21 79.28 Quite High
Leukemia 9 61.52 Quite High
Disease 1 59.80 Quite High
Stress 5 56.48 Quite High
Parkinson's Disease 4 55.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, stautosporine, a protein kinase inhibitor, did not affect the mRNA levels of SOD1 and SOD2, but decreased protein and activity levels of both enzymes [48].
Transcription (levels) of SOD2
1) Confidence 0.70 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.30 Pain Relevance 0.16
Mitochondrial manganese-containing superoxide dismutase (MnSOD) activity and mRNA expression were assayed by activity staining after separation on the polyacrylamide gel electrophoresis, and reverse transcriptase-polymerase chain reaction (RT-PCR), respectively.
Transcription (expression) of MnSOD
2) Confidence 0.67 Published 2003 Journal Anesthesiology Section Body Doc Link 12606908 Disease Relevance 0.07 Pain Relevance 0
Codeinone did not significantly change the manganese superoxide dismutase (MnSOD) activity nor its mRNA expression.
Transcription (expression) of MnSOD
3) Confidence 0.67 Published 2003 Journal Anticancer Res. Section Abstract Doc Link 12894543 Disease Relevance 0.96 Pain Relevance 0.25
Codeinone did not significantly change the manganese superoxide dismutase (MnSOD) activity nor its mRNA expression.
Transcription (expression) of manganese superoxide dismutase
4) Confidence 0.59 Published 2003 Journal Anticancer Res. Section Abstract Doc Link 12894543 Disease Relevance 0.97 Pain Relevance 0.25
Calcitriol treatment results in reduced mRNA and protein levels of RelB and its target genes survivin, Bcl-2 and MnSOD, and sensitizes the breast cancer cells Hs578T and NF639 to gamma-irradiation.
Transcription (levels) of MnSOD associated with breast cancer
5) Confidence 0.24 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 1.20 Pain Relevance 0

General Comments

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