INT108868

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 2.91
Pain Relevance 4.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
endothelial cells 1
astrocytes 1
Nfkbia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 18 99.40 Very High Very High Very High
aspirin 2 96.70 Very High Very High Very High
intrathecal 12 94.40 High High
Inflammation 5 92.52 High High
Sciatic nerve 3 92.00 High High
Neuropathic pain 3 91.00 High High
allodynia 9 89.76 High High
Pain 18 80.16 Quite High
COX-2 inhibitor 2 79.44 Quite High
cytokine 21 77.16 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 9 92.52 High High
Neuropathic Pain 12 91.00 High High
Stomach Cancer 3 87.88 High High
Pain 12 80.16 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 72.88 Quite High
Necrosis 3 54.72 Quite High
Cancer 3 54.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No or low levels of IkappaBalpha mRNA were detected in the lumbar spinal cord of vehicle-injected rats, whereas IkappaBalpha mRNA expression was markedly induced in the spinal cord following intrathecal gp120 in predominantly astrocytes and endothelial cells.
Transcription (detected) of IkappaBalpha mRNA in astrocytes associated with intrathecal and spinal cord
1) Confidence 0.57 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 0.79 Pain Relevance 1.26
To reveal NF-kappaB activation, we assessed inhibitory factor kappaBalpha (IkappaBalpha) mRNA expression by in situ hybridization, as NF-kappaB activation up-regulates IkappaBalpha gene expression as part of an autoregulatory feedback loop.
Transcription (expression) of IkappaBalpha
2) Confidence 0.51 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 0.97 Pain Relevance 1.26
No or low levels of IkappaBalpha mRNA were detected in the lumbar spinal cord of vehicle-injected rats, whereas IkappaBalpha mRNA expression was markedly induced in the spinal cord following intrathecal gp120 in predominantly astrocytes and endothelial cells.
Transcription (detected) of IkappaBalpha mRNA in endothelial cells associated with intrathecal and spinal cord
3) Confidence 0.19 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 0.79 Pain Relevance 1.26
Furthermore, unlike aspirin, SC236 affected neither the phosphorylation, degradation, nor expression of IkappaB-alpha, suggesting that the effects of SC236 are independent of IKK activity and IkappaB-alpha gene transcription.
Transcription (transcription) of IkappaB-alpha associated with aspirin
4) Confidence 0.01 Published 2003 Journal Oncogene Section Abstract Doc Link 12606945 Disease Relevance 0.36 Pain Relevance 0.25

General Comments

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