INT108869

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Context Info
Confidence 0.56
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.04
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
nucleus 1
endometrium 1
Nfkbia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 14 99.54 Very High Very High Very High
Endep 11 99.36 Very High Very High Very High
aspirin 2 99.36 Very High Very High Very High
COX2 1 99.36 Very High Very High Very High
Dismenorea 6 96.00 Very High Very High Very High
intrathecal 4 95.44 Very High Very High Very High
cINOD 1 95.12 Very High Very High Very High
Antinociceptive 2 89.32 High High
Inflammation 7 87.52 High High
COX-2 inhibitor 2 82.44 Quite High
Disease Link Frequency Relevance Heat
Stomach Cancer 3 98.16 Very High Very High Very High
Dysmenorrhea 3 96.00 Very High Very High Very High
INFLAMMATION 9 94.92 High High
Necrosis 1 80.16 Quite High
Cancer 1 79.80 Quite High
Rheumatoid Arthritis 5 76.64 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Sepsis 2 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, amitriptyline/morphine co-infusion increased IkappaBalpha phosphorylation and the translocation of NF-kappaB p65 from the cytosol to the nucleus.
Localization (translocation) of IkappaBalpha in nucleus associated with endep and morphine
1) Confidence 0.56 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.85
In addition, PPF pretreatment attenuated the phosphorylation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and IkappaBalpha, as well as the nuclear translocation of NF-kappaB primed by LPS.
Localization (translocation) of IkappaBalpha
2) Confidence 0.53 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.29 Pain Relevance 0.18
Compared with normal endometrium, progesterone receptor isoform B (PR-B) and IkappaBalpha immunoreactivity were statistically significantly reduced in ectopic as well as eutopic endometrium from women with adenomyosis while nuclear p65, p50, and p52 immunoreactivity were statistically significantly increased in ectopic and eutopic endometrium.
Localization (immunoreactivity) of IkappaBalpha in endometrium associated with dismenorea
3) Confidence 0.17 Published 2009 Journal Fertil. Steril. Section Abstract Doc Link 19296948 Disease Relevance 0.17 Pain Relevance 0.29
NF-kappaB activation was detected using Western blotting to follow degradation of IkappaBalpha and nuclear localization of the p65 subunit of NF-kappaB.
Localization (localization) of IkappaBalpha
4) Confidence 0.07 Published 2009 Journal Lasers Surg Med Section Body Doc Link 19347944 Disease Relevance 0.15 Pain Relevance 0
Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer.
Localization (translocation) of IkappaB-alpha associated with aspirin and stomach cancer
5) Confidence 0.01 Published 2003 Journal Oncogene Section Title Doc Link 12606945 Disease Relevance 0.43 Pain Relevance 0.31

General Comments

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