INT108875

Context Info Confidence 0.49 First Reported 2001 Last Reported 2009 Negated 2 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 1.43 Pain Relevance 1.72

cytosol (RELA) nucleoplasm (RELA) aging (RELA) nucleus (RELA) DNA binding (RELA) transcription factor binding (RELA)

Anatomy Link Frequency neurons 2 nucleus 2 RELA (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 36 99.70 COX2 1 99.70 Hippocampus 14 97.04 cINOD 9 94.44 withdrawal 9 91.20 Morphine 6 90.76 cytokine 40 89.04 Inflammation 100 86.84 Catechol-O-methyltransferase 111 84.20 Inflammatory marker 3 82.40

Disease Link Frequency Relevance Heat Stomach Cancer 3 97.48 Skin Cancer 2 96.00 Melanoma 1 94.76 INFLAMMATION 124 94.24 Premature Aging 1 92.84 Burns 2 91.64 Anaplastic Astrocytoma 8 83.12 Age-related Macular Degeneration 2 74.80 Aging 21 72.00 Wrinkles 3 59.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Protein kinase A activation then prevents the phosphorylation and subsequent degradation of IkappaB, which in turn prevents translocation of the NF-kappaB p65 subunit to the nucleus to transactivate the IL-12 p40 gene, ultimately resulting in decreased IL-12 production following LPS stimulation.

Positive_regulation (following) of Localization (translocation) of p65 in nucleus

1) Confidence 0.49 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18322172 Disease Relevance 0 Pain Relevance 0.79

Simultaneous incubation of HCAEC with antisense RelA p65 and NF-?

Positive_regulation (antisense) of Localization (incubation) of p65

2) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0

Simultaneous incubation of HCAEC with antisense RelA p65 and NF-?

Positive_regulation (antisense) of Localization (incubation) of RelA

3) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0

Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer.

Neg (independent) Positive_regulation (independent) of Localization (translocation) of RelA associated with aspirin and stomach cancer

4) Confidence 0.45 Published 2003 Journal Oncogene Section Title Doc Link 12606945 Disease Relevance 0.42 Pain Relevance 0.31

Pretreatment (1 hr) of SP600125 suppressed the inhibitory effect of melittin and bee venom on LPS and SNP-induced nuclear translocation of the p50 and p65 in Raw 264.7 cells (Fig. 3A) and in synoviocytes (Fig. 3B).

Positive_regulation (induced) of Localization (translocation) of p65

5) Confidence 0.17 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0 Pain Relevance 0

in the cytoplasmic fraction of the cells and simultaneous increase in the nuclear level of p65 was observed at 30 min (Figure 4B and 4C), characteristic of dynamic NF-?

Positive_regulation (increase) of Localization (level) of p65

6) Confidence 0.11 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.08 Pain Relevance 0.35

Using an antibody specific for activated p65 [24], here a colocalization of constitutive NF-?

Positive_regulation (activated) of Localization (colocalization) of p65

7) Confidence 0.09 Published 2002 Journal BMC Mol Biol Section Body Doc Link PMC140029 Disease Relevance 0 Pain Relevance 0.05

Immediately evident is the overlap of both stainings in many, but not all neurons (arrow heads in Fig. 1 and Fig. 2), where the activated p65 subunit is localized in the nucleus and the COX-2 protein in the corresponding cytoplasm of the same neuron.

Neg (not) Positive_regulation (activated) of Localization (localized) of p65 subunit in neurons

8) Confidence 0.09 Published 2002 Journal BMC Mol Biol Section Body Doc Link PMC140029 Disease Relevance 0 Pain Relevance 0.13

In one study, immunohistochemical and Western blot analysis and ELISA indicated that both nuclear p65 and secreted IL-6 were significantly (p < 0.05) induced by UVB (20, 30 mJ/cm2) and UVA irradiation (10, 20 J/cm2).

Positive_regulation (induced) of Localization (secreted) of p65

9) Confidence 0.06 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.92 Pain Relevance 0.09

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