INT108875

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.43
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RELA) nucleoplasm (RELA) aging (RELA)
nucleus (RELA) DNA binding (RELA) transcription factor binding (RELA)
Anatomy Link Frequency
neurons 2
nucleus 2
RELA (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 36 99.70 Very High Very High Very High
COX2 1 99.70 Very High Very High Very High
Hippocampus 14 97.04 Very High Very High Very High
cINOD 9 94.44 High High
withdrawal 9 91.20 High High
Morphine 6 90.76 High High
cytokine 40 89.04 High High
Inflammation 100 86.84 High High
Catechol-O-methyltransferase 111 84.20 Quite High
Inflammatory marker 3 82.40 Quite High
Disease Link Frequency Relevance Heat
Stomach Cancer 3 97.48 Very High Very High Very High
Skin Cancer 2 96.00 Very High Very High Very High
Melanoma 1 94.76 High High
INFLAMMATION 124 94.24 High High
Premature Aging 1 92.84 High High
Burns 2 91.64 High High
Anaplastic Astrocytoma 8 83.12 Quite High
Age-related Macular Degeneration 2 74.80 Quite High
Aging 21 72.00 Quite High
Wrinkles 3 59.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein kinase A activation then prevents the phosphorylation and subsequent degradation of IkappaB, which in turn prevents translocation of the NF-kappaB p65 subunit to the nucleus to transactivate the IL-12 p40 gene, ultimately resulting in decreased IL-12 production following LPS stimulation.
Positive_regulation (following) of Localization (translocation) of p65 in nucleus
1) Confidence 0.49 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18322172 Disease Relevance 0 Pain Relevance 0.79
Simultaneous incubation of HCAEC with antisense RelA p65 and NF-?
Positive_regulation (antisense) of Localization (incubation) of p65
2) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Simultaneous incubation of HCAEC with antisense RelA p65 and NF-?
Positive_regulation (antisense) of Localization (incubation) of RelA
3) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer.
Neg (independent) Positive_regulation (independent) of Localization (translocation) of RelA associated with aspirin and stomach cancer
4) Confidence 0.45 Published 2003 Journal Oncogene Section Title Doc Link 12606945 Disease Relevance 0.42 Pain Relevance 0.31
Pretreatment (1 hr) of SP600125 suppressed the inhibitory effect of melittin and bee venom on LPS and SNP-induced nuclear translocation of the p50 and p65 in Raw 264.7 cells (Fig. 3A) and in synoviocytes (Fig. 3B).
Positive_regulation (induced) of Localization (translocation) of p65
5) Confidence 0.17 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0 Pain Relevance 0
in the cytoplasmic fraction of the cells and simultaneous increase in the nuclear level of p65 was observed at 30 min (Figure 4B and 4C), characteristic of dynamic NF-?
Positive_regulation (increase) of Localization (level) of p65
6) Confidence 0.11 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.08 Pain Relevance 0.35
Using an antibody specific for activated p65 [24], here a colocalization of constitutive NF-?
Positive_regulation (activated) of Localization (colocalization) of p65
7) Confidence 0.09 Published 2002 Journal BMC Mol Biol Section Body Doc Link PMC140029 Disease Relevance 0 Pain Relevance 0.05
Immediately evident is the overlap of both stainings in many, but not all neurons (arrow heads in Fig. 1 and Fig. 2), where the activated p65 subunit is localized in the nucleus and the COX-2 protein in the corresponding cytoplasm of the same neuron.
Neg (not) Positive_regulation (activated) of Localization (localized) of p65 subunit in neurons
8) Confidence 0.09 Published 2002 Journal BMC Mol Biol Section Body Doc Link PMC140029 Disease Relevance 0 Pain Relevance 0.13
In one study, immunohistochemical and Western blot analysis and ELISA indicated that both nuclear p65 and secreted IL-6 were significantly (p < 0.05) induced by UVB (20, 30 mJ/cm2) and UVA irradiation (10, 20 J/cm2).
Positive_regulation (induced) of Localization (secreted) of p65
9) Confidence 0.06 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.92 Pain Relevance 0.09

General Comments

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