INT10888

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Context Info
Confidence 0.46
First Reported 1991
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 32
Total Number 34
Disease Relevance 22.87
Pain Relevance 5.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vwf) cell adhesion (Vwf) endoplasmic reticulum (Vwf)
proteinaceous extracellular matrix (Vwf) molecular_function (Vwf) response to stress (Vwf)
Anatomy Link Frequency
platelet 12
plasma 5
blood 2
chest 2
tail 1
Vwf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 89 99.70 Very High Very High Very High
Angina 31 99.20 Very High Very High Very High
Migraine 8 99.16 Very High Very High Very High
local anesthetic 1 97.68 Very High Very High Very High
antagonist 13 96.56 Very High Very High Very High
cva 121 94.84 High High
peptic ulcer disease 7 93.80 High High
Inflammatory response 6 93.36 High High
ischemia 12 93.20 High High
Inflammatory marker 18 92.60 High High
Disease Link Frequency Relevance Heat
Myocardial Infarction 239 100.00 Very High Very High Very High
Coronary Artery Disease 153 100.00 Very High Very High Very High
Death 107 100.00 Very High Very High Very High
Atherosclerosis 72 99.90 Very High Very High Very High
Rheumatoid Arthritis 101 99.70 Very High Very High Very High
Adhesions 21 99.68 Very High Very High Very High
Hemorrhage 27 99.40 Very High Very High Very High
Complex Regional Pain Syndromes 6 99.38 Very High Very High Very High
Coronary Heart Disease 91 99.32 Very High Very High Very High
Headache 9 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enhanced shear-induced von Willebrand factor binding to platelets in acute myocardial infarction.
von Willebrand factor Binding (binding) of in platelets associated with myocardial infarction
1) Confidence 0.46 Published 2000 Journal Thromb. Res. Section Title Doc Link 11113268 Disease Relevance 0.55 Pain Relevance 0.09
The effects of plasma obtained from 15 patients with acute myocardial infarction and 10 patients with the chest pain syndrome as controls, on shear-induced vWF binding to platelets and subsequent platelet activation, as evidenced by microparticle release, were investigated by quantitative flow cytometry.
vWF Binding (binding) of in plasma associated with complex regional pain syndromes, angina and myocardial infarction
2) Confidence 0.46 Published 2000 Journal Thromb. Res. Section Abstract Doc Link 11113268 Disease Relevance 0.44 Pain Relevance 0.10
We conclude that the plasma of acute myocardial infarction patients contains factors that enhance shear-induced vWF binding and vWF-mediated platelet activation, which may contribute to thrombotic re-occlusions of the coronary arteries in patients who have received reperfusion treatments.
vWF Binding (binding) of in plasma associated with myocardial infarction
3) Confidence 0.46 Published 2000 Journal Thromb. Res. Section Abstract Doc Link 11113268 Disease Relevance 0.57 Pain Relevance 0
The shear-induced increase in vWF binding to the platelet surface was enhanced in the presence of plasma from patients with acute myocardial infarction (acute myocardial infarction plasma).
vWF Binding (binding) of in plasma associated with myocardial infarction
4) Confidence 0.46 Published 2000 Journal Thromb. Res. Section Abstract Doc Link 11113268 Disease Relevance 0.75 Pain Relevance 0.07
The number of vWF molecules bound to the platelet surface and the number of microparticles released from the platelets were then measured by quantitative flow cytometry using an FITC-conjugated anti-vWF monoclonal antibody.
vWF Binding (bound) of in platelets
5) Confidence 0.46 Published 2000 Journal Thromb. Res. Section Abstract Doc Link 11113268 Disease Relevance 0.65 Pain Relevance 0.08
Acute myocardial infarction plasma also reduced the shear rate threshold required to induce measurable shear-induced vWF binding from 10800 s(-1) to 9000 s(-1).
vWF Binding (binding) of in plasma associated with myocardial infarction
6) Confidence 0.46 Published 2000 Journal Thromb. Res. Section Abstract Doc Link 11113268 Disease Relevance 0.60 Pain Relevance 0
The authors determined von Willebrand factor (vWF) in 63 persons with migraine, 11 persons with migraine and prior stroke, and 35 frequency-matched controls.
vWF Spec (determined) Binding (determined) of associated with stroke and migraine
7) Confidence 0.36 Published 2001 Journal Neurology Section Abstract Doc Link 11468324 Disease Relevance 0.69 Pain Relevance 0.45
The authors determined von Willebrand factor (vWF) in 63 persons with migraine, 11 persons with migraine and prior stroke, and 35 frequency-matched controls.
von Willebrand factor Spec (determined) Binding (determined) of associated with stroke and migraine
8) Confidence 0.36 Published 2001 Journal Neurology Section Abstract Doc Link 11468324 Disease Relevance 0.69 Pain Relevance 0.44
Blood group O individuals also have a higher risk of bleeding disorders due to low levels of the circulating plasma protein von Willebrand factor (vWf). vWf is one of the main proteins that binds platelets during platelet activation and aggregation.
vWf Binding (binds) of in Blood associated with coagulation disorder
9) Confidence 0.35 Published 2009 Journal Med. Hypotheses Section Abstract Doc Link 19423238 Disease Relevance 1.35 Pain Relevance 0.25
Our new hypothesis states that H. pylori bacteria present in blood group O/non-secretor individuals are binding the available vWf to promote adhesion and subsequent platelet aggregation within the microvasculature.
vWf Binding (binding) of in blood associated with adhesions
10) Confidence 0.35 Published 2009 Journal Med. Hypotheses Section Abstract Doc Link 19423238 Disease Relevance 1.27 Pain Relevance 0.22
Platelet interaction with collagen may be indirect, due to binding of the VWF-collagen complex with glycoprotein Ib-IX-V (GPIb-IX-V) or ?
VWF Binding (binding) of in Platelet
11) Confidence 0.35 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0.19 Pain Relevance 0.11
Decreased von Willebrand factor cleaving protease activity (VWFCP, ADAMTS 13) leads to persistence of unusually large multimers of von Willebrand factor that bind to platelets, causing platelet aggregates, microangiopathic hemolysis, and thrombocytopenia in patients with thrombotic thrombocytopenic purpura (TTP).
von Willebrand factor Binding (bind) of in platelet associated with hemolysis, thrombocytopenia and thrombotic thrombocytopenic purpura
12) Confidence 0.25 Published 2004 Journal Am. J. Hematol. Section Abstract Doc Link 14755376 Disease Relevance 0.83 Pain Relevance 0.06
We immunohistochemically assessed the localizations and their changes over time of glycoprotein IIb/IIIa, fibrin, von Willebrand factor (vWF), and tissue factor (TF), after the onset of chest pain (<4, 4 to 6, or 6 to 12 hours), in fresh coronary thrombi causing acute myocardial infarction.
von Willebrand factor Binding (time) of in chest associated with angina and myocardial infarction
13) Confidence 0.23 Published 2006 Journal Am. J. Cardiol. Section Abstract Doc Link 16377278 Disease Relevance 0.46 Pain Relevance 0.10
We immunohistochemically assessed the localizations and their changes over time of glycoprotein IIb/IIIa, fibrin, von Willebrand factor (vWF), and tissue factor (TF), after the onset of chest pain (<4, 4 to 6, or 6 to 12 hours), in fresh coronary thrombi causing acute myocardial infarction.
vWF Binding (time) of in chest associated with angina and myocardial infarction
14) Confidence 0.23 Published 2006 Journal Am. J. Cardiol. Section Abstract Doc Link 16377278 Disease Relevance 0.46 Pain Relevance 0.10
Consequently, questions concerning numbness and tingling, a two-point discrimination test, Phalen's test, and Tinell's test had a high predicting value for VWF.
VWF Binding (value) of in VWF
15) Confidence 0.20 Published 2009 Journal Int Arch Occup Environ Health Section Body Doc Link 18781317 Disease Relevance 0 Pain Relevance 0
METHODS: Plasma levels of von Willebrand factor (vWF) antigen, vWF collagen binding activity, vWF-cleaving-protease, CRP, and whole-blood platelet reactivity were measured before and 24 h after angioplasty in 18 patients with recent unstable angina and in 17 with stable angina.
vWF Binding (activity) of in blood platelet
16) Confidence 0.15 Published 2002 Journal J. Thromb. Thrombolysis Section Body Doc Link 12714832 Disease Relevance 0.19 Pain Relevance 0
After angioplasty, virtually all patients with unstable angina and raised preprocedural CRP showed increased vWF antigen (P = 0.01), vWF collagen-binding (P = 0.001), CRP (P = 0.008), and platelet reactivity (P = 0.0007) compared to baseline, whereas no significant change of these variables was seen within the other three sets of patients.
vWF Binding (binding) of in platelet
17) Confidence 0.15 Published 2002 Journal J. Thromb. Thrombolysis Section Body Doc Link 12714832 Disease Relevance 0.14 Pain Relevance 0
A mild to moderate deficiency of factor VIII and von Willebrand factor (vWf) often is associated with gingival bleeding.
vWf Binding (associated) of associated with hemorrhage
18) Confidence 0.14 Published 1999 Journal J. Periodontol. Section Abstract Doc Link 10368060 Disease Relevance 0.53 Pain Relevance 0.12
A mild to moderate deficiency of factor VIII and von Willebrand factor (vWf) often is associated with gingival bleeding.
von Willebrand factor Binding (associated) of associated with hemorrhage
19) Confidence 0.14 Published 1999 Journal J. Periodontol. Section Abstract Doc Link 10368060 Disease Relevance 0.53 Pain Relevance 0.12
Peptides with collagen-binding properties have previously been reported: cyclic peptides mimicking the collagen-binding site of vWF bound to rat tail collagen, and inhibited vWF binding to calfskin and human collagen, but only at high concentrations [24]; phage display also made it possible to identify the collagen-binding protein rNecH1 from Necator americanus [25], but no further use of these peptides or proteins has been reported.
vWF Binding (binding) of in tail
20) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680759 Disease Relevance 0.07 Pain Relevance 0.10

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