INT10889

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Context Info
Confidence 0.78
First Reported 1982
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 60
Total Number 61
Disease Relevance 41.36
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F8) oxidoreductase activity (F8) extracellular region (F8)
cell adhesion (F8)
Anatomy Link Frequency
plasma 4
hepatocytes 3
liver 3
platelet 2
endothelial cells 2
F8 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 9 99.24 Very High Very High Very High
Paracetamol 15 98.76 Very High Very High Very High
corticosteroid 21 98.32 Very High Very High Very High
Angina 13 98.24 Very High Very High Very High
Inflammatory response 22 97.90 Very High Very High Very High
cva 123 97.82 Very High Very High Very High
epidural 7 96.96 Very High Very High Very High
analgesia 6 96.60 Very High Very High Very High
Inflammation 60 94.16 High High
anesthesia 22 93.68 High High
Disease Link Frequency Relevance Heat
Coagulation Disorder 101 100.00 Very High Very High Very High
Severe Combined Immunodeficiency 141 99.96 Very High Very High Very High
Psychosis 46 99.84 Very High Very High Very High
Multiple Myeloma 22 99.84 Very High Very High Very High
Cancer 63 99.76 Very High Very High Very High
Hyperhomocysteinemia 2 99.70 Very High Very High Very High
Acute Liver Failure 24 99.68 Very High Very High Very High
Disease 289 99.64 Very High Very High Very High
Myocardial Infarction 31 99.56 Very High Very High Very High
Thrombophilia 25 98.94 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the liver is the primary site of factor VIII (FVIII) synthesis, we hypothesized that the partial replacement of mutated liver cells by healthy cells in hemophilia A mice could manage the severity of the bleeding disorder.
Gene_expression (synthesis) of factor VIII in liver associated with coagulation disorder
1) Confidence 0.78 Published 2009 Journal Blood Section Abstract Doc Link 19752394 Disease Relevance 0.36 Pain Relevance 0.08
Because the liver is the primary site of factor VIII (FVIII) synthesis, we hypothesized that the partial replacement of mutated liver cells by healthy cells in hemophilia A mice could manage the severity of the bleeding disorder.
Gene_expression (synthesis) of FVIII in liver associated with coagulation disorder
2) Confidence 0.78 Published 2009 Journal Blood Section Abstract Doc Link 19752394 Disease Relevance 0.36 Pain Relevance 0.08
The BMC-recipient mice expressed FVIII protein and survived in a tail clip challenge experiment.
Gene_expression (expressed) of FVIII protein in tail
3) Confidence 0.78 Published 2009 Journal Blood Section Abstract Doc Link 19752394 Disease Relevance 0.30 Pain Relevance 0.08
We have attempted to identify nonhepatocytic sites of fVIII biosynthesis by inducing FHF in mice using acetaminophen overdose, a common cause of human FHF.
Gene_expression (biosynthesis) of fVIII associated with paracetamol, acute liver failure and overdose
4) Confidence 0.77 Published 2003 Journal Blood Section Abstract Doc Link 12730105 Disease Relevance 0.80 Pain Relevance 0.35
Concurrently, factor VIII (fVIII) procoagulant activity rises despite destruction of the hepatocytes considered responsible for fVIII synthesis.
Gene_expression (synthesis) of fVIII in hepatocytes
5) Confidence 0.77 Published 2003 Journal Blood Section Abstract Doc Link 12730105 Disease Relevance 0.73 Pain Relevance 0.31
The lack of any effect on mouse embryonic transplants, regardless of the expression of Factor VIII by the host or the donor, suggests that the role of Factor VIII is likely limited to a checkpoint of excessive growth, which operates upon implantation of tissue from a larger animal, such as the pig.
Gene_expression (expression) of Factor VIII
6) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0.51 Pain Relevance 0
This observation suggests a role for cells other than hepatocytes in fVIII biosynthesis during FHF.
Gene_expression (biosynthesis) of fVIII in hepatocytes associated with acute liver failure
7) Confidence 0.60 Published 2003 Journal Blood Section Abstract Doc Link 12730105 Disease Relevance 0.77 Pain Relevance 0.33
Laboratory testing performed to exclude a hypercoaguable state, revealed heterozygosity for the Factor V Leiden mutation/activated protein C resistance and elevated factor VIII levels [3660 IU l(-1) (<1500)].
Gene_expression (resistance) of factor VIII
8) Confidence 0.56 Published 2003 Journal Br J Radiol Section Abstract Doc Link 12893701 Disease Relevance 0.57 Pain Relevance 0.04
The tumor cells were positive for factor VIII-related antigen and Weibel-Palade bodies.
Gene_expression (positive) of factor VIII associated with cancer
9) Confidence 0.56 Published 1987 Journal Dig. Dis. Sci. Section Abstract Doc Link 3691279 Disease Relevance 0.60 Pain Relevance 0.13
However, in type 1, the increased synthesis of von Willebrand factor (vWF) and factor VIII (FVIII:C) during pregnancy can lead to a correction of biological abnormalities and may allow epidural analgesia to be performed for delivery.
Gene_expression (synthesis) of factor VIII associated with congenital anomalies, epidural and analgesia
10) Confidence 0.53 Published 2007 Journal Int J Obstet Anesth Section Abstract Doc Link 17509867 Disease Relevance 0.27 Pain Relevance 0.40
However, in type 1, the increased synthesis of von Willebrand factor (vWF) and factor VIII (FVIII:C) during pregnancy can lead to a correction of biological abnormalities and may allow epidural analgesia to be performed for delivery.
Gene_expression (synthesis) of FVIII associated with congenital anomalies, epidural and analgesia
11) Confidence 0.53 Published 2007 Journal Int J Obstet Anesth Section Abstract Doc Link 17509867 Disease Relevance 0.27 Pain Relevance 0.40
Fig. 1A shows a typical oversized pig E42 spleen implant grown for 12 weeks in Factor VIII KO SCID recipient, versus the size of a similar implant grown in a Factor VIII expressing SCID recipient.
Gene_expression (expressing) of Factor VIII in spleen associated with severe combined immunodeficiency
12) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0.61 Pain Relevance 0
The lack of any effect on mouse embryonic transplants, regardless of whether the host or the donor is derived from a hemophilic or non-hemophilic mouse, suggests that the role of Factor VIII is likely limited to oversize growth checkpoint that operates upon implantation of tissue from a larger animal, such as the pig.
Gene_expression (role) of Factor VIII
13) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0.07 Pain Relevance 0
In the patient with the highest levels of FVIII expression, the therapeutic effects lasted for 10 months, although FVIII expression finally disappeared.
Gene_expression (expression) of FVIII
14) Confidence 0.48 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.14 Pain Relevance 0
Nonetheless, there are reports of therapeutic levels of FVIII expression for a limited period of time using this viral system [165, 166].
Gene_expression (expression) of FVIII
15) Confidence 0.48 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.09 Pain Relevance 0
There is only one study where factor VIII has been expressed from a BAC containing the entire genomic locus [118].
Gene_expression (expressed) of factor VIII
16) Confidence 0.48 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.17 Pain Relevance 0
Although a demonstration of functional FVIII expression from the BAC awaits the use of cell lines or mice with null endogenous expression, this is the first characterized genomic clone carrying the intact locus which could potentially be useful for therapeutic applications [118].

4.4.

Gene_expression (expression) of FVIII
17) Confidence 0.48 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.55 Pain Relevance 0
In the patient with the highest levels of FVIII expression, the therapeutic effects lasted for 10 months, although FVIII expression finally disappeared.
Gene_expression (expression) of FVIII
18) Confidence 0.48 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.14 Pain Relevance 0
In a second trial, a B-domain-deleted cDNA was expressed from a moloney murine leukaemia virus-based (retroviral) vector [169], which only produced levels of FVIII expression above 1% sporadically, concluding that efficient retroviral transduction would probably require higher doses and some degree of mitotic induction.
Gene_expression (expression) of FVIII associated with leukemia
19) Confidence 0.48 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.16 Pain Relevance 0
There is evidence of the expression of the FVIII cDNA with the B-domain deleted from retroviral vectors in different cells lines, from human skin fibroblasts [153, 154] to bone marrow stromal cells [155].
Gene_expression (expression) of FVIII in stromal cells
20) Confidence 0.48 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.17 Pain Relevance 0

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