INT108902

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Context Info
Confidence 0.13
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.31
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GNAS) intracellular (GNAS) GTPase activity (GNAS)
transmembrane transport (GNAS) cytoplasm (GNAS) signal transducer activity (GNAS)
GNAS (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 5 75.16 Quite High
Crohn's disease 8 71.16 Quite High
Pain 1 57.44 Quite High
cytokine 3 29.64 Quite Low
Inflammation 13 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 96 94.44 High High
Crohn's Disease 6 88.08 High High
Body Weight 1 85.04 High High
Eating Disorder 1 81.36 Quite High
Disease 56 79.04 Quite High
Cancer 3 74.60 Quite High
Tauopathy 36 74.44 Quite High
Contagious Ecthyma 2 73.52 Quite High
Pain 1 57.44 Quite High
Rickettsiaceae Infection 16 49.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The amplification profile for all loci with the exception of gpsA was as follows: 94°C for 4 minutes (1 cycle), followed by 35 cycles of 94°C for 30 sec, 55°C for 30 sec, 72°C for 30 sec and 1 cycle of 72°C for 5 minutes.
Neg (exception) Localization (exception) of gpsA
1) Confidence 0.13 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2907413 Disease Relevance 0.13 Pain Relevance 0
Seven housekeeping gene loci were selected: gpsA, mdh, nrdB, nuoF, ppdK, sucD, and sucB.
Localization (selected) of gpsA
2) Confidence 0.06 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2907413 Disease Relevance 0.35 Pain Relevance 0
Another strategy that is often employed to stimulate the inclusion or exclusion of a specific exon is to use bifunctional oligoribonucleotides.
Localization (exclusion) of exon
3) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0.22 Pain Relevance 0
Due to the involvement of many factors in the process of alternative splicing, one would expect that any change of these elements in the overall equation would tip the balance of exon inclusion/exclusion.
Localization (exclusion) of exon
4) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0 Pain Relevance 0
Sequence inspection suggested that the NOD2 mRNA isoform with exon1a being joined directly to exon 2 (alt 5'UTR NOD2 a) allows translation from the very first ATG localized in exon 2.
Localization (localized) of exon
5) Confidence 0.02 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.37 Pain Relevance 0.04
We postulate that NPGPR is a splice variant of the family of NPFF receptors and displays a binding profile different from the other members of the NPFF receptor family due to the presence of exon 1.
Localization (presence) of exon
6) Confidence 0.00 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12609745 Disease Relevance 0.22 Pain Relevance 0.19

General Comments

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