INT108903

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.58
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GNAS) intracellular (GNAS) GTPase activity (GNAS)
transmembrane transport (GNAS) cytoplasm (GNAS) signal transducer activity (GNAS)
Anatomy Link Frequency
osteoclasts 1
DRG 1
GNAS (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 2 99.24 Very High Very High Very High
qutenza 6 96.68 Very High Very High Very High
Clonidine 20 94.16 High High
Pain 8 94.16 High High
Neuropeptide 5 93.44 High High
TRP channel 1 93.28 High High
anesthesia 1 90.68 High High
agonist 14 90.16 High High
Potency 2 85.04 High High
analgesia 3 78.92 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 3 98.56 Very High Very High Very High
Pain 5 94.16 High High
Rickets 3 90.32 High High
Nociception 4 83.04 Quite High
Cancer 85 81.60 Quite High
Infection 32 80.76 Quite High
Immunodeficiency 2 80.12 Quite High
Hypercalcemia 8 75.92 Quite High
Sleep Disorders 1 72.44 Quite High
Metastasis 3 68.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The gene expression profile of primary osteoclasts and osteoblasts has been evaluated ex vivo following tenofovir exposure.61,62 Specific downregulation of Gnas, Got2, and Snord32a was observed in osteoclasts.
Negative_regulation (downregulation) of Gnas in osteoclasts
1) Confidence 0.57 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2946855 Disease Relevance 0.46 Pain Relevance 0
We show that in human the rarely used exon VIII of BDNF is exclusively spliced to exon V.
Negative_regulation (spliced) of exon VIII
2) Confidence 0.06 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0
We show that in human the rarely used exon VIII of BDNF is exclusively spliced to exon V.
Negative_regulation (spliced) of exon
3) Confidence 0.06 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0
Intravenous administration of dexmedetomidine similarly diminishes the volatile anesthetic (Aho et al., 1992) and opioid (But et al., 2006) requirements.
Negative_regulation (diminishes) of Aho associated with opioid
4) Confidence 0.03 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2658019 Disease Relevance 0.41 Pain Relevance 1.49
The human TRPV1 splice variant, TRPV1b, lacking exon 7, was cloned from human dorsal root ganglia (DRG) RNA.
Negative_regulation (lacking) of exon in DRG
5) Confidence 0.01 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 17018028 Disease Relevance 0 Pain Relevance 0.29
Actual CTIP2 is the one lacking exon 3.
Negative_regulation (lacking) of exon
6) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.62 Pain Relevance 0
Here, we characterize the full-length cloned NPGPR and identify a novel short form lacking exon 2 with a differential pattern of mRNA abundance in several tissues and organs.
Negative_regulation (lacking) of exon
7) Confidence 0.00 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12609745 Disease Relevance 0.09 Pain Relevance 0.27

General Comments

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