INT108911

Context Info Confidence 0.41 First Reported 2002 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.81 Pain Relevance 0.60

transport (HTR3A) plasma membrane (HTR3A) transmembrane transport (HTR3A)

HTR3A (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 47 100.00 Serotonin 6 100.00 Cannabinoid 2 93.44 dopamine receptor 1 91.76 anesthesia 1 80.36 corticosteroid 13 72.08 dexamethasone 26 66.20 Neurotransmitter 5 52.20 transdermal 60 50.00 cerebral cortex 1 34.44

Disease Link Frequency Relevance Heat Vomiting 195 100.00 Post-operative Nausea 6 100.00 Adverse Drug Reaction 1 85.60 Anxiety Disorder 1 82.16 Pressure Volume 2 Under Development 1 80.72 Cancer 9 37.48 Erythema 6 5.00 Headache 6 5.00 Intestinal Obstruction 6 5.00 Constipation 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

[Prevention of postoperative nausea and vomiting with highly selective 5-HT3 serotonin receptors antagonists during different types of surgery].

Negative_regulation ([Prevention) of Gene_expression (antagonists) of 5-HT3 associated with post-operative nausea, antagonist, vomiting and serotonin

1) Confidence 0.41 Published 2002 Journal Anesteziol Reanimatol Section Title Doc Link 12611303 Disease Relevance 0.61 Pain Relevance 0.28

Metoclopramide administered in high doses acquires the capacity to block 5HT3 receptors, which improves its efficacy but it has frequent side effects.7,25

Negative_regulation (block) of Gene_expression (receptors) of 5HT3

2) Confidence 0.41 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004574 Disease Relevance 1.20 Pain Relevance 0.32

General Comments

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