INT108917

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 23
Total Number 28
Disease Relevance 21.32
Pain Relevance 10.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CRX)
Anatomy Link Frequency
brain 3
cleavage 2
rectum 1
ACC 1
amygdala 1
CRX (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 32 99.84 Very High Very High Very High
amygdala 396 99.68 Very High Very High Very High
Visceral pain 83 99.64 Very High Very High Very High
Somatosensory cortex 15 99.60 Very High Very High Very High
Hippocampus 15 99.60 Very High Very High Very High
agonist 48 99.48 Very High Very High Very High
Thalamus 20 99.02 Very High Very High Very High
Central nervous system 4 98.52 Very High Very High Very High
Pain 101 98.20 Very High Very High Very High
Inflammation 49 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

540 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 270 100.00 Very High Very High Very High
Stress 217 100.00 Very High Very High Very High
Neuroleptic Malignant Syndrome 9 99.90 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

83 99.64 Very High Very High Very High
Pain 101 98.20 Very High Very High Very High
INFLAMMATION 51 98.00 Very High Very High Very High
Hyperalgesia 14 97.20 Very High Very High Very High
Liver Disease 3 96.88 Very High Very High Very High
Syndrome 15 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, almost two-thirds of nonserotonergic cells responded to CRD stimulation with either excitatory (35%) or inhibitory (30%) responses to CRD.
Positive_regulation (stimulation) of CRD
1) Confidence 0.50 Published 2003 Journal J. Neurophysiol. Section Abstract Doc Link 12612047 Disease Relevance 0.08 Pain Relevance 0.48
The CRD stimulation was induced by the distention of a balloon inserted into the colorectum.
Positive_regulation (induced) of CRD
2) Confidence 0.43 Published 2006 Journal J Physiol Sci Section Abstract Doc Link 16839445 Disease Relevance 0 Pain Relevance 0.17
A phasic increasing CRD paradigm from 10 to 80mmHg with 10mmHg intervals induced a clear stimulus-response relationship with a strong correlation (r(2)=0.93) between the electrical and mechanical responses.
Positive_regulation (increasing) of CRD
3) Confidence 0.21 Published 2005 Journal Pain Section Abstract Doc Link 15936885 Disease Relevance 0 Pain Relevance 0
ACC microinjection of 2 mmol/L glutamate increased the VMR to CRD (10 mm Hg) in viscerally hypersensitive rats, and 20 mmol/L glutamate induced a more potent VMR in viscerally hypersensitive than in normal rats.
Positive_regulation (increased) of CRD in ACC
4) Confidence 0.21 Published 2008 Journal Gastroenterology Section Body Doc Link 18242219 Disease Relevance 0 Pain Relevance 0
Recent studies claimed to have performed functional brain activation in unrestrained conscious rats in response to CRD [47], however the results from these studies must be treated with caution.
Positive_regulation (response) of CRD in brain
5) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0.45 Pain Relevance 0.06
CORT-treated rats also displayed activation in the sensory processing areas such as the somatosensory cortex during the 40 mmHg CRD that were not activated at the same distension pressure in CHOL controls (Figure 6A–B).
Neg (not) Positive_regulation (activated) of CRD in cortex associated with somatosensory cortex
6) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0.08 Pain Relevance 0.26
These data indicate that chronic exposure of the amygdala to elevated levels of CORT enhances overall brain activation in response to CRD, and identified other specific brain regions activated in response to mechanical distension of the colon.
Positive_regulation (activation) of CRD in brain associated with amygdala
7) Confidence 0.13 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2797306 Disease Relevance 0.24 Pain Relevance 0.32
In this part of the study we used the same experimental design as that employed in the fMRI investigation, and examined the histological appearance of the colonic mucosa from rats that underwent CRD and compared the findings to naïve rats.
Positive_regulation (underwent) of CRD
8) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0.22 Pain Relevance 0.43
A significant advance made in the current study was the enhanced brain activation in response to CRD in rats with CORT-containing micropellets placed stereotaxically on the dorsal margin of the amygdala.
Positive_regulation (activation) of CRD in brain associated with amygdala
9) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0.17 Pain Relevance 0.22
To our knowledge, no specific studies with these new vitamin E preparations have been conducted in CRD.
Positive_regulation (conducted) of CRD associated with disorder of lipid metabolism
10) Confidence 0.07 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2956717 Disease Relevance 1.34 Pain Relevance 0.35
In conclusion, an elevated level of CK in a patient with hypocholesterolemia can suggest CRD.
Spec (suggest) Positive_regulation (suggest) of CRD associated with disorder of lipid metabolism
11) Confidence 0.07 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2956717 Disease Relevance 1.19 Pain Relevance 0
Only two families have had frame shift mutations that cause CRD.
Positive_regulation (cause) of CRD associated with disorder of lipid metabolism
12) Confidence 0.06 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2956717 Disease Relevance 0.59 Pain Relevance 0
CRD was caused by insertion of a lubricated latex balloon into the descending colon and rectum followed by inflation to 80mm Hg for 10min.
Positive_regulation (caused) of CRD in descending colon
13) Confidence 0.06 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417688 Disease Relevance 0.16 Pain Relevance 0.42
Three putative heparin-binding sequences were identified within the CRD-spacer sequence of ADAMTS-4, one within the CRD and two within the spacer, and peptides corresponding to these sequences were shown to inhibit the binding of ADAMTS-4 to heparin [9].
Positive_regulation (sequence) of CRD
14) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0 Pain Relevance 0
A recent study of truncated recombinant forms of ADAMTS-4 indicated that the presence of the CRD was required for maximal aggrecanase activity, whereas the inclusion of the spacer region prevented cleavage of aggrecan at the IGD site [27].
Positive_regulation (required) of CRD in cleavage
15) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.08 Pain Relevance 0
In addition, the requirement of the CRD for optimal cleavage of glycosylated aggrecan compared with its negligible influences on the cleavage of non-proteoglycan substrates suggests that this domain promotes hyalectan cleavage by mediating interactions with sulphated glycosaminoglycan, in a similar manner to that proposed for the activation by heparan sulphate of growth-factor-receptor signalling [87].
Positive_regulation (requirement) of CRD in cleavage
16) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.12 Pain Relevance 0
Sauvagine (10 or 20 microg/kg, s.c.) abolished the 226.7+/-64.3% and 90.4+/-38.1% increase in AUC to the 2nd CRD compared with the 1st CRD (performed 30 min before) in female Fisher and Sprague-Dawley (SD) rats, respectively.
Positive_regulation (increase) of CRD
17) Confidence 0.04 Published 2005 Journal Peptides Section Abstract Doc Link 15949637 Disease Relevance 0 Pain Relevance 0.26
Distally, CRFR1 is decreased in WKY rats following CRD but not OF stress without any apparent changes in SD rats.
Neg (not) Positive_regulation (following) of CRD associated with stress
18) Confidence 0.04 Published 2010 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19807869 Disease Relevance 0.43 Pain Relevance 0
Functional magnetic resonance imaging in anesthetized rats revealed that the amygdala, thalamus, cerebellum, and hippocampus were significantly activated during CRD-induced visceral pain (19).
Positive_regulation (activated) of CRD in hippocampus associated with visceral pain, hippocampus, thalamus, amygdala and imagery
19) Confidence 0.04 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 0.17 Pain Relevance 1.08
After CRD, the number of pERK-positive neurons significantly increased compared to control animals.
Positive_regulation (increased) of CRD in neurons
20) Confidence 0.03 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 0.09 Pain Relevance 0.31

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