INT108921

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Context Info
Confidence 0.25
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.80
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk9) mitochondrion (Mapk9) nucleus (Mapk9)
kinase activity (Mapk9) transcription factor binding (Mapk9) cytoplasm (Mapk9)
Anatomy Link Frequency
liver 2
Mapk9 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 18 100.00 Very High Very High Very High
Leflunomide 10 99.98 Very High Very High Very High
cytokine 1 90.96 High High
Arthritis 1 87.64 High High
Analgesic 1 59.00 Quite High
Inflammation 1 54.24 Quite High
fibrosis 1 53.12 Quite High
Disease Link Frequency Relevance Heat
Injury 5 99.92 Very High Very High Very High
Pathologic Processes 1 99.76 Very High Very High Very High
Overdose 1 99.08 Very High Very High Very High
Apoptosis 3 98.46 Very High Very High Very High
Liver Failure 1 97.00 Very High Very High Very High
Respiratory Disease 1 89.88 High High
Hepatotoxicity 4 88.92 High High
Cancer 1 87.96 High High
Arthritis 1 87.64 High High
Stress 2 82.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.
Negative_regulation (inhibiting) of Positive_regulation (activation) of c-Jun N-terminal kinase in liver associated with paracetamol, injury and apoptosis
1) Confidence 0.25 Published 2008 Journal Gastroenterology Section Title Doc Link 18700144 Disease Relevance 0.58 Pain Relevance 0.47
Instead, leflunomide inhibited APAP-induced activation (phosphorylation) of c-jun NH2-terminal protein kinase (JNK), thus preventing downstream Bcl-2 and Bcl-XL inactivation and protecting from mitochondrial permeabilization and cytochrome c release.
Negative_regulation (inhibited) of Positive_regulation (activation) of c-jun NH2-terminal protein kinase associated with paracetamol and leflunomide
2) Confidence 0.23 Published 2007 Journal Hepatology Section Abstract Doc Link 17366662 Disease Relevance 0.51 Pain Relevance 1.37
NAC inhibits activation of c-Jun N-terminal kinase, p38 MAP kinase and redox-sensitive activating protein-1 and nuclear factor kappa B transcription factor activities regulating expression of numerous genes.
Negative_regulation (inhibits) of Positive_regulation (activation) of c-Jun N-terminal kinase
3) Confidence 0.07 Published 2003 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 12613655 Disease Relevance 0.71 Pain Relevance 0.14

General Comments

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