INT10893

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Context Info
Confidence 0.47
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 25.02
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (VWF) cell adhesion (VWF) endoplasmic reticulum (VWF)
proteinaceous extracellular matrix (VWF)
Anatomy Link Frequency
platelets 15
plasma 5
blood 1
portal vein 1
uterine 1
VWF (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 25 99.78 Very High Very High Very High
Angina 43 98.16 Very High Very High Very High
noradrenaline 1 96.64 Very High Very High Very High
Restless leg syndrome 2 96.20 Very High Very High Very High
Serotonin 19 95.04 Very High Very High Very High
aspirin 141 92.96 High High
abdominal pain 1 89.80 High High
adenocard 5 89.12 High High
ischemia 11 86.88 High High
cva 24 85.28 High High
Disease Link Frequency Relevance Heat
Stress 34 99.92 Very High Very High Very High
Coronary Artery Disease 33 99.76 Very High Very High Very High
Cancer 100 99.72 Very High Very High Very High
Coronary Heart Disease 19 99.32 Very High Very High Very High
Cv Unclassified Under Development 9 99.24 Very High Very High Very High
Hemolytic Anemia 39 99.08 Very High Very High Very High
Vasculitis 5 99.04 Very High Very High Very High
Hemorrhage 165 98.64 Very High Very High Very High
Myocardial Infarction 85 98.62 Very High Very High Very High
Thrombotic Thrombocytopenic Purpura 23 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CR-TM shares certain clinical similarities with thrombotic thrombocytopenic purpura such as neurological and renal impairment; also both are characterized by circulating platelet aggregates containing ultra large multimers of Von Willebrand factor (VWF).
VWF Binding (multimers) of in platelet associated with thrombotic thrombocytopenic purpura
1) Confidence 0.47 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1310632 Disease Relevance 1.46 Pain Relevance 0
To evaluate the association between the vWF-GPIb interaction and the enhanced shear-induced platelet aggregation (SIPA) observed in ACSs, we tested the effect of this antibody on platelet aggregation.
vWF Binding (interaction) of in platelet associated with acute coronary syndrome
2) Confidence 0.36 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10195912 Disease Relevance 0.96 Pain Relevance 0.22
These findings suggest that the vWF-GPIb interaction is important in coronary occlusion and that inhibition of this interaction (with the use of AJvW-2) may prevent further events in the coronary arteries.
vWF Binding (interaction) of associated with coronary heart disease
3) Confidence 0.36 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10195912 Disease Relevance 0.97 Pain Relevance 0.28
A monoclonal antibody, AJvW-2, directed against the A1 domain of human vWF specifically blocks the interaction between plasma vWF and platelet glycoprotein (GP) Ib.
vWF Binding (interaction) of in platelet
4) Confidence 0.36 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10195912 Disease Relevance 0.86 Pain Relevance 0.20
In the myocardial infarction group, univariate analysis showed that atherothrombotic events were associated with high fibrinogen (p = 0.001), factor VIII:C (p less than 0.001), and von Willebrand factor antigen (vWF:Ag) (p = 0.004) levels and with low high density lipoprotein cholesterol (p = 0.043), factor VII (p = 0.019), and protein C (p = 0.044) levels; multivariate analysis produced associations with high fibrinogen and factor VIII:C levels and low protein C levels.
von Willebrand factor Binding (associated) of associated with myocardial infarction
5) Confidence 0.36 Published 1992 Journal Arterioscler. Thromb. Section Abstract Doc Link 1525121 Disease Relevance 0.82 Pain Relevance 0.17
subunit of the glycoprotein Ib-V-IX complex that interacts with subendothelial von Willebrand factor to ensure recruitment of platelets at sites of vascular injury [56].
von Willebrand factor Binding (interacts) of in platelets associated with vasculitis
6) Confidence 0.36 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.27 Pain Relevance 0
We studied patients with intermittent claudication to see if the progression of peripheral arterial disease and the risks of coronary events could be predicted by baseline packed cell volume, plasma fibrinogen, blood and plasma viscosites, von Willebrand factor antigen, cross-linked fibrin degradation products (XLFDP), urinary fibrinopeptide A, and plasma leucocyte elastase.
von Willebrand factor Binding (cross-linked) of in plasma associated with restless leg syndrome and peripheral arterial disease
7) Confidence 0.36 Published 1993 Journal Lancet Section Abstract Doc Link 8100915 Disease Relevance 0.85 Pain Relevance 0.10
The patient was investigated thoroughly by a haematologist and all blood investigations including coagulation profile, Factor XI bioassay, PFA-100 platelet function tests, vWF:antigen assay and vWF:collagen binding were normal.
vWF Binding (binding) of in platelet
8) Confidence 0.35 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2599901 Disease Relevance 1.02 Pain Relevance 0.14
The patient was investigated thoroughly by a haematologist and all blood investigations including coagulation profile, Factor XI bioassay, PFA-100 platelet function tests, vWF:antigen assay and vWF:collagen binding were normal.
vWF Binding (binding) of in platelet
9) Confidence 0.35 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2599901 Disease Relevance 1.07 Pain Relevance 0.14
Factor VIIIc, von Willebrand factor (vWF), tPA and PAI-1 are reported to be associated with CHD.
vWF Binding (associated) of associated with coronary artery disease
10) Confidence 0.35 Published 1997 Journal Int. J. Clin. Lab. Res. Section Abstract Doc Link 9352376 Disease Relevance 1.20 Pain Relevance 0.14
Factor VIIIc, von Willebrand factor (vWF), tPA and PAI-1 are reported to be associated with CHD.
von Willebrand factor Binding (associated) of associated with coronary artery disease
11) Confidence 0.35 Published 1997 Journal Int. J. Clin. Lab. Res. Section Abstract Doc Link 9352376 Disease Relevance 1.21 Pain Relevance 0.14
3 results in a disturbed interaction between activated platelets and adhesive glycoproteins (fibrinogen at low shear and vWF at high shear) that bridge adjacent platelets during platelet aggregation (Fig. 1a).
vWF Binding (interaction) of in platelets
12) Confidence 0.25 Published 2007 Journal Eur J Pediatr Section Body Doc Link PMC2042511 Disease Relevance 1.16 Pain Relevance 0.05
[High plasma levels of factor VIII and von Willebrand factor in a patient with portal vein thrombosis].
von Willebrand factor Binding (levels) of in portal vein associated with cv unclassified under development
13) Confidence 0.23 Published 2002 Journal Z Gastroenterol Section Title Doc Link 12055664 Disease Relevance 0.85 Pain Relevance 0.16
Fibrin and von Willebrand factor bind to the GP IIb/IIIa receptor and trap multiple activated platelets leading to their aggregation.
von Willebrand factor Binding (bind) of in platelets
14) Confidence 0.21 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.26 Pain Relevance 0.18
Recent biochemical data indicate that the platelet glycoprotein (GP) IIb/IIIa receptor mediates platelet aggregation by binding fibrinogen, von Willebrand factor, or other ligands, that can span between platelets.
von Willebrand factor Binding (binding) of in platelet
15) Confidence 0.19 Published 1995 Journal Eur. Heart J. Section Abstract Doc Link 8869013 Disease Relevance 0.34 Pain Relevance 0
Hereby, abciximab inhibits the final common pathway for platelet aggregation by preventing the binding of fibrinogen and von Willebrand factor to activated platelets [22].
von Willebrand factor Binding (binding) of in platelets
16) Confidence 0.13 Published 2009 Journal Trials Section Body Doc Link PMC2765937 Disease Relevance 0.29 Pain Relevance 0
We studied patients with intermittent claudication to see if the progression of peripheral arterial disease and the risks of coronary events could be predicted by baseline packed cell volume, plasma fibrinogen, blood and plasma viscosites, von Willebrand factor antigen, cross-linked fibrin degradation products (XLFDP), urinary fibrinopeptide A, and plasma leucocyte elastase.
von Willebrand factor Binding (cross-linked) of in blood associated with restless leg syndrome and peripheral arterial disease
17) Confidence 0.12 Published 1993 Journal Lancet Section Abstract Doc Link 8100915 Disease Relevance 0.85 Pain Relevance 0.10
This was shown by in-vitro binding of PEGLip-formulated FVIII to vWF.45 Thus binding of PEGLip to FVIII does not change the protein’s biological properties.
vWF Binding (binding) of
18) Confidence 0.12 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2939703 Disease Relevance 0 Pain Relevance 0
It dissociates from vWF, interacts with negatively charged phospholipids on the surface of activated platelets, and acts as a cofactor for factor IXa in the activation of factor X.1 This in turn leads to the generation of substantial amounts of thrombin, the key enzyme in the coagulation cascade, and to the generation of a hemostatic plug.
vWF Binding (interacts) of in platelets
19) Confidence 0.09 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2939703 Disease Relevance 0.52 Pain Relevance 0.03
FVIII is a large glycoprotein (2332 amino acids) that is synthesized as a 330 kDa precursor and undergoes multiple processing steps to yield a heterodimer composed of a light chain (80 kDa) and a heterogeneous heavy chain (90–210 kDa)9 FVIII circulates in the plasma as an inactive precursor, tightly complexed with von Willebrand factor (vWF).
vWF Binding (complexed) of in plasma
20) Confidence 0.09 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2939703 Disease Relevance 0.55 Pain Relevance 0.03

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