INT108931

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 38
Total Number 39
Disease Relevance 19.61
Pain Relevance 8.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)
Anatomy Link Frequency
brain 9
neuronal 3
neurons 3
SH-SY5Y 2
cortex 2
BDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 90 100.00 Very High Very High Very High
Nerve growth factor 57 100.00 Very High Very High Very High
Glutamate 16 100.00 Very High Very High Very High
excitatory amino acid 1 99.96 Very High Very High Very High
depression 312 99.84 Very High Very High Very High
agonist 10 99.58 Very High Very High Very High
Desipramine 25 99.52 Very High Very High Very High
tetrodotoxin 10 99.40 Very High Very High Very High
Hippocampus 55 99.36 Very High Very High Very High
Kinase C 82 99.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 695 99.84 Very High Very High Very High
Depression 405 99.84 Very High Very High Very High
Apoptosis 11 99.60 Very High Very High Very High
Virus Diseases 94 99.48 Very High Very High Very High
Stress 330 99.42 Very High Very High Very High
Major Depressive Disorder 58 99.34 Very High Very High Very High
Fibrosis 4 99.08 Very High Very High Very High
Depressive Disorder 102 99.00 Very High Very High Very High
Targeted Disruption 25 98.24 Very High Very High Very High
Manic Depressive Disorder 36 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present results suggest that early reduction of total BDNF mRNA in SH-SY5Y cells was mainly accounted for by a reduction of BDNF IV by RBX and DMI administration, and of BDNF VIa/b by RBX.
Negative_regulation (reduction) of BDNF mRNA in SH-SY5Y associated with desipramine
1) Confidence 0.59 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.12 Pain Relevance 0.53
Previous studies have shown that BDNF mRNA is consistently reduced in cells and in vivo brain tissues from HD transgenic mice and patients [3].
Negative_regulation (reduced) of BDNF mRNA in brain associated with targeted disruption and disease
2) Confidence 0.57 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0.65 Pain Relevance 0
A blockade of visual inputs for 24 h by an injection of tetrodotoxin into both eyes significantly decreased brain-derived neurotrophic factor protein level in the visual cortex, but not in the other regions in both young and adult ferrets.
Neg (not) Negative_regulation (decreased) of brain-derived neurotrophic factor protein in cortex associated with tetrodotoxin
3) Confidence 0.45 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614676 Disease Relevance 0 Pain Relevance 0.30
Given the remarkable reduction in brain BDNF mRNA levels in HD, we set up a fast, accurate, and standardized method for BDNF mRNA detection in blood.
Negative_regulation (reduction) of BDNF mRNA in blood associated with disease
4) Confidence 0.42 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0.67 Pain Relevance 0.03
2M) mRNA, the analyses produced different quantifications of BDNF mRNA levels normalized to these two different reference genes (median value BDNF mRNA/GAPDH mRNA, 1; median value BDNF mRNA/?
Negative_regulation (levels) of BDNF mRNA
5) Confidence 0.42 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0.08 Pain Relevance 0
This neuronal loss was associated with down-regulation of multipotency marker, Oct4 and neurotrophins, indicating abnormal brain development.


Negative_regulation (regulation) of neurotrophin in brain
6) Confidence 0.42 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 1.10 Pain Relevance 0.15
Whether impairment of PKC signaling may in fact explain the inhibition of neurotrophin response in BDV-infected neurons is currently under study.
Negative_regulation (inhibition) of neurotrophin in neurons associated with virus diseases and kinase c
7) Confidence 0.41 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.67 Pain Relevance 0.49
In DRG neurons, a succession of neurotrophin and GFL signalling regulates the differentiation of nociceptor subpopulations.
Negative_regulation (succession) of neurotrophin in neurons associated with nociceptor
8) Confidence 0.41 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.30
A list of all these promoters is provided in Table 6 and comprises several neurotrophins and growth factors, such as FGF, EGF, Pleiotrophin, or PEDF, morphogens from the TGF?
Negative_regulation (comprises) of neurotrophin
9) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0
Blockade of cortical neuronal activities by a GABA(A) receptor agonist led to a remarkable reduction of brain-derived neurotrophic factor protein in the visual cortex.
Negative_regulation (reduction) of brain-derived neurotrophic factor protein in neuronal associated with gaba and agonist
10) Confidence 0.40 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614676 Disease Relevance 0 Pain Relevance 0.31
The present results suggest that early reduction of total BDNF mRNA in SH-SY5Y cells was mainly accounted for by a reduction of BDNF IV by RBX and DMI administration, and of BDNF VIa/b by RBX.
Negative_regulation (reduction) of BDNF IV in SH-SY5Y associated with desipramine
11) Confidence 0.37 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.13 Pain Relevance 0.52
Here we tested whether GAPDH is a stable control gene for brain tissues versus EAR and whether normalization over EAR still confirms the finding of a robust reduction in BDNF mRNA in HD cortical samples over controls [8].
Negative_regulation (reduction) of BDNF mRNA in brain associated with disease
12) Confidence 0.37 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0.35 Pain Relevance 0.06
By this reasoning, it can be concluded that high levels of TrkB and PAI-1 imply decreased levels of BDNF, which is detrimental for the survival of neuronal populations.
Negative_regulation (decreased) of BDNF in neuronal associated with bdmf
13) Confidence 0.37 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.74 Pain Relevance 0.54
We found BDNF to be decreased by 1.07 in the AD affected samples.
Negative_regulation (decreased) of BDNF associated with disease and bdmf
14) Confidence 0.37 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.74 Pain Relevance 0.43
Furthermore, blocking exogenous NGF or BDNF by binding it to antibody prevents tarenflurbil from protecting human neuronal cells from Abeta_{42} and H_{2}O_{2} cytotoxicity.
Negative_regulation (blocking) of BDNF in neuronal associated with nerve growth factor
15) Confidence 0.37 Published 2008 Journal J. Alzheimers Dis. Section Abstract Doc Link 18997293 Disease Relevance 0.33 Pain Relevance 0.38
2M) mRNA, the analyses produced different quantifications of BDNF mRNA levels normalized to these two different reference genes (median value BDNF mRNA/GAPDH mRNA, 1; median value BDNF mRNA/?
Negative_regulation (/) of BDNF mRNA
16) Confidence 0.36 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0.08 Pain Relevance 0
2M) mRNA, the analyses produced different quantifications of BDNF mRNA levels normalized to these two different reference genes (median value BDNF mRNA/GAPDH mRNA, 1; median value BDNF mRNA/?
Negative_regulation (value) of BDNF mRNA
17) Confidence 0.36 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0.08 Pain Relevance 0
In light of the current understanding of depressive disorder pathogenesis, Mossner et al. (2007) deduced that decreased BDNF levels, increased IL-6 levels, reduced folate levels, reduced total cholesterol levels, and elevated cortisol levels are among the most promising biomarkers for identifying and distinguishing among MDDs.
Negative_regulation (decreased) of BDNF associated with disorder of lipid metabolism and depressive disorder
18) Confidence 0.36 Published 2010 Journal Frontiers in Neuroengineering Section Body Doc Link PMC2901135 Disease Relevance 0.53 Pain Relevance 0.06
Decreased levels of BDNF have been linked to AD and depression [38-40].
Negative_regulation (Decreased) of BDNF associated with depression, disease and bdmf
19) Confidence 0.36 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.61 Pain Relevance 0.53
In this context, it is striking that 100% of animals in our experimental stress group showed >1SD increase in proBDNF levels (and corresponding decrease in mature BDNF).
Negative_regulation (decrease) of BDNF associated with stress
20) Confidence 0.34 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 0.50 Pain Relevance 0.03

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