INT108932

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Context Info
Confidence 0.40
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 1.65
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NTF4)
Anatomy Link Frequency
nerve 3
cortex 1
NTF4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 58 100.00 Very High Very High Very High
pruritus 59 99.00 Very High Very High Very High
Calcitonin gene-related peptide 7 96.52 Very High Very High Very High
substance P 10 96.28 Very High Very High Very High
Somatosensory cortex 2 85.20 High High
Hippocampus 1 83.44 Quite High
Somatostatin 2 79.84 Quite High
chemokine 5 79.72 Quite High
Neuropeptide 19 78.96 Quite High
unmyelinated 1 66.64 Quite High
Disease Link Frequency Relevance Heat
Death 35 99.12 Very High Very High Very High
Pruritus 78 99.00 Very High Very High Very High
Spinal Cord Injury 265 97.00 Very High Very High Very High
Psoriasis 60 90.20 High High
Motor Neuron Diseases 5 84.40 Quite High
Demyelinating Disease 5 58.52 Quite High
Injury 165 31.36 Quite Low
Apoptosis 29 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Contusions 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, hMNPs expressed NT-3, NT-4, and NGF, which, have all been shown to have beneficial effects following SCI [24], [25].
Gene_expression (expressed) of NT-4 associated with nerve growth factor and spinal cord injury
1) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.72 Pain Relevance 0.12
S1b) indicated that hMNPs both express and secrete neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), nerve growth factor (NGF), and vascular endothelial-derived growth factor (VEGF).
Gene_expression (express) of neurotrophin-4 in nerve associated with nerve growth factor
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0 Pain Relevance 0.16
S1b) indicated that hMNPs both express and secrete neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), nerve growth factor (NGF), and vascular endothelial-derived growth factor (VEGF).
Gene_expression (express) of NT-4 in nerve associated with nerve growth factor
3) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0 Pain Relevance 0.17
Proteins were probed with antibodies against NT-3, NT-4, NGF (1?
Gene_expression (probed) of NT-4 associated with nerve growth factor
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0 Pain Relevance 0.05
8 ┬Ám in the presence of anti-NT4 (p<0.01), 149+/?
Gene_expression (presence) of anti-NT4
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0 Pain Relevance 0.05
Those include GDNF (Widmer et al., 2000), BDNF, NT-3, NT-4/5, nerve growth factor (NGF) (Studer et al., 1995; Studer et al., 1996), and TGF-alpha (Alexi and Hefti, 1993).
Gene_expression (/) of NT-4 in nerve associated with nerve growth factor
6) Confidence 0.06 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0 Pain Relevance 0.05
neurotrophin-4, low-affinity receptor for NGF, PACAP receptor expression, as
Gene_expression (expression) of neurotrophin-4
7) Confidence 0.02 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2221678 Disease Relevance 0.93 Pain Relevance 0.79
To test this, we measured protein levels of nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5 in visual cortex of young (postnatal day 38-46, at the peak of the critical period) and adult ferrets with two-site enzyme-immunoassay systems.
Gene_expression (levels) of neurotrophin-4 in cortex associated with nerve growth factor
8) Confidence 0.02 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614676 Disease Relevance 0 Pain Relevance 0.20

General Comments

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