INT108937

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.31
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arrb2) cytoplasmic membrane-bounded vesicle (Arrb2) plasma membrane (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) cytoplasm (Arrb2)
Anatomy Link Frequency
brain 2
hippocampus 2
Arrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 4 99.84 Very High Very High Very High
Morphine 20 99.76 Very High Very High Very High
Central grey 6 99.56 Very High Very High Very High
cerebral cortex 6 98.20 Very High Very High Very High
Locus ceruleus 4 87.60 High High
tolerance 4 86.88 High High
narcan 2 84.72 Quite High
withdrawal 2 82.96 Quite High
opioid receptor 4 78.76 Quite High
agonist 2 76.64 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 6 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, after chronic morphine treatment, beta-arrestin 2 mRNA level decreased by 40% in periaqueductal gray and increased by 25% in cerebral cortex, in strong contrast to the unchanged beta-arrestin 1 mRNA level in these two brain regions.
Negative_regulation (decreased) of Transcription (level) of beta-arrestin 2 in brain associated with cerebral cortex, central grey and morphine
1) Confidence 0.38 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614678 Disease Relevance 0.20 Pain Relevance 1.31
Our results showed that the acute morphine administration (10 mg/kg) resulted in approximately 30% reduction in both beta-arrestin 1 and beta-arrestin 2 mRNA levels in hippocampus while the chronic morphine treatment (10 mg/kg, b.i.d., for 9 days) caused no significant change in level of either beta-arrestin mRNA.
Negative_regulation (reduction) of Transcription (levels) of beta-arrestin 2 in hippocampus associated with hippocampus and morphine
2) Confidence 0.38 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614678 Disease Relevance 0.11 Pain Relevance 1.00

General Comments

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