INT108943

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Context Info
Confidence 0.61
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arrb2) cytoplasmic membrane-bounded vesicle (Arrb2) plasma membrane (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) cytoplasm (Arrb2)
Anatomy Link Frequency
hippocampus 2
Arrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 10 99.46 Very High Very High Very High
Hippocampus 2 99.36 Very High Very High Very High
tolerance 2 88.08 High High
Locus ceruleus 2 86.64 High High
opioid receptor 2 79.96 Quite High
agonist 1 77.84 Quite High
Central grey 3 60.40 Quite High
cerebral cortex 3 58.48 Quite High
narcan 1 35.52 Quite Low
withdrawal 1 33.76 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 3 60.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results showed that the acute morphine administration (10 mg/kg) resulted in approximately 30% reduction in both beta-arrestin 1 and beta-arrestin 2 mRNA levels in hippocampus while the chronic morphine treatment (10 mg/kg, b.i.d., for 9 days) caused no significant change in level of either beta-arrestin mRNA.
Positive_regulation (resulted) of Negative_regulation (reduction) of beta-arrestin 2 in hippocampus associated with hippocampus and morphine
1) Confidence 0.61 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614678 Disease Relevance 0.06 Pain Relevance 0.97

General Comments

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