INT10896

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Context Info
Confidence 0.61
First Reported 1986
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 16
Total Number 19
Disease Relevance 4.22
Pain Relevance 4.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (PTAFR) plasma membrane (PTAFR) nucleus (PTAFR)
signal transducer activity (PTAFR)
Anatomy Link Frequency
platelet 6
cholinergic neurons 1
muscle 1
HL-60 1
skin 1
PTAFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 125 100.00 Very High Very High Very High
Antihistamine 6 100.00 Very High Very High Very High
Codeine 1 100.00 Very High Very High Very High
anesthesia 3 99.92 Very High Very High Very High
antagonist 63 99.80 Very High Very High Very High
bradykinin 14 99.80 Very High Very High Very High
qutenza 27 99.60 Very High Very High Very High
Inflammatory response 8 99.04 Very High Very High Very High
cINOD 2 98.84 Very High Very High Very High
cva 3 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 148 100.00 Very High Very High Very High
Disease 17 99.88 Very High Very High Very High
Increased Venous Pressure Under Development 9 99.40 Very High Very High Very High
Chronic Disease 3 98.92 Very High Very High Very High
Neonatal Necrotizing Enterocolitis 68 98.76 Very High Very High Very High
Decompression Sickness 3 98.16 Very High Very High Very High
Leukemia 1 98.16 Very High Very High Very High
Adult Respiratory Distress Syndrome 4 97.36 Very High Very High Very High
Anaphylaxis 3 96.60 Very High Very High Very High
Wheal 13 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the interaction of PAF and AAG suggests that serum AAG, which fluctuates in a number of diseases, may function to regulate PAF activity during acute and chronic disease states.
Spec (may) Regulation (function) of PAF associated with disease and chronic disease
1) Confidence 0.61 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3947392 Disease Relevance 0.25 Pain Relevance 0.11
Specific factors which stabilize PAF and/or regulate PAF activity in body fluids are largely unknown.
Regulation (regulate) of PAF in body
2) Confidence 0.61 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3947392 Disease Relevance 0.19 Pain Relevance 0.09
We studied the regulation of PAF activity by capsaicin in human promyelocytic leukemia HL-60 cells.
Regulation (regulation) of PAF in HL-60 associated with leukemia and qutenza
3) Confidence 0.59 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11034409 Disease Relevance 0.20 Pain Relevance 0.57
Effects of H1- and H2-antihistamines on platelet-activating factor and bradykinin-induced inflammatory responses in human skin.
Regulation (Effects) of platelet-activating factor in skin associated with inflammatory response, antihistamine, bradykinin and codeine
4) Confidence 0.45 Published 1996 Journal Clin. Exp. Dermatol. Section Title Doc Link 8689766 Disease Relevance 0.69 Pain Relevance 0.71
The effect of salmeterol and nimesulide on chemotaxis and synthesis of PAF and LTC4 by human eosinophils.
Regulation (effect) of PAF in eosinophils
5) Confidence 0.44 Published 1996 Journal Eur Respir J Suppl Section Title Doc Link 8871060 Disease Relevance 0.09 Pain Relevance 0.21
To begin addressing the possible signaling mechanisms that may underlie PAF-mediated regulation of TLR expression, we evaluated the potential roles of two major transcription factors regulated by PAF, STAT3 [32] and NF-?
Regulation (regulation) of PAF-mediated
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.06 Pain Relevance 0.06
We re-examined this issue and compared the effects of the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe), phorbol myristate acetate (PMA), ATP, platelet activating factor (PAF), cytochalasin B (CB) and prostaglandin E1 (PGE1) with those of various opioids on O2- formation in human neutrophils and HL-60 leukemic cells under defined experimental conditions.
Regulation (effects) of PAF in platelet associated with opioid
7) Confidence 0.42 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2552328 Disease Relevance 0 Pain Relevance 0.57
Lidocaine up to millimolar concentrations did not affect the PAF priming and formyl-methyl-leucyl-phenylalanine activation of oxidative burst.
Neg (not) Regulation (affect) of PAF
8) Confidence 0.41 Published 2010 Journal Reg Anesth Pain Med Section Body Doc Link 20048657 Disease Relevance 0 Pain Relevance 0
These data point to PAF as a major inflammatory mediator released by epithelial cells to affect circular muscle contraction.41 PAF inhibits neurally mediated contraction by inhibiting release of acetylcholine from cholinergic neurons (Fig. 12).
Regulation (affect) of PAF in cholinergic neurons associated with inflammation
9) Confidence 0.40 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.22 Pain Relevance 0.25
The roles of platelet-activating factor (PAF) in pulmonary vasoconstriction during venous air embolism in anesthetized mongrel dogs.
Regulation (roles) of PAF in platelet associated with anesthesia, decompression sickness, cva and increased venous pressure under development
10) Confidence 0.39 Published 1992 Journal J Lipid Mediat Section Title Doc Link 1525361 Disease Relevance 0.39 Pain Relevance 0.27
If so, the location of a cell in the culture plate in relation to other cells will determine its response to PAF.
Spec (determine) Regulation (response) of PAF
11) Confidence 0.38 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0 Pain Relevance 0.03
This is consistent with release of PAF by epithelial cells in response to activation of TRPV1 by capsaicin and indicates that PAF is a major inflammatory mediator affecting circular muscle contraction.
Regulation (affecting) of PAF in muscle associated with inflammation and qutenza
12) Confidence 0.33 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.25 Pain Relevance 0.65
Twenty microlitres of different pruritogenic substances [histamine, substance P, neurokinin A, neurokinin B, trypsin, platelet-activating factor (PAF) and serotonin] and saline as control were injected intradermally into the inflamed test sites and in corresponding non-treated sites on the opposite forearm.
Regulation (control) of platelet-activating factor in platelet
13) Confidence 0.30 Published 2002 Journal Br. J. Dermatol. Section Body Doc Link 12000375 Disease Relevance 0.08 Pain Relevance 0
Furthermore, the interaction of PAF and AAG suggests that serum AAG, which fluctuates in a number of diseases, may function to regulate PAF activity during acute and chronic disease states.
Regulation (regulate) of PAF associated with disease and chronic disease
14) Confidence 0.27 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3947392 Disease Relevance 0.20 Pain Relevance 0.11
To assess the influence of platelet-activating factor on epithelial function isolated from lamina propria elements, monolayers were cultured from a human colonic epithelial cell line (T-84). 4.
Regulation (influence) of platelet-activating factor in platelet
15) Confidence 0.27 Published 1995 Journal Clin. Sci. Section Abstract Doc Link 7705001 Disease Relevance 0 Pain Relevance 0.10
N-(6-ammohexyl)-5-chloro-1-naphtalenesulfonamide hydrochloride, a calmodulin antagonist, did not affect the response to PAF.
Neg (not) Regulation (affect) of PAF associated with antagonist
16) Confidence 0.26 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8858995 Disease Relevance 0.52 Pain Relevance 0.49
We have previously shown that platelet activating factor (PAF), bacteria and TLR4 are all important factors in the development of NEC.
Regulation (important) of platelet activating factor in platelet associated with neonatal necrotizing enterocolitis
17) Confidence 0.25 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955554 Disease Relevance 0.46 Pain Relevance 0
Current therapies include NSAIDs' that inhibit cyclooxygenases (COX-1, COX-2) but have no effect on the production of leukotrienes or platelet activating factor (PAF).
Neg (no) Regulation (effect) of PAF in platelet associated with cinod
18) Confidence 0.17 Published 2005 Journal Curr. Med. Chem. Section Abstract Doc Link 16378502 Disease Relevance 0.55 Pain Relevance 0.27
RESULTS: In the untreated patients, the PAF EC50 values were significantly lower on the day of admission, whereas the maximal percentage of aggregation was significantly higher compared to controls (p < 0.01 for both comparisons).
Regulation (values) of PAF
19) Confidence 0.05 Published 1999 Journal Cardiovasc. Res. Section Body Doc Link 10536703 Disease Relevance 0.08 Pain Relevance 0

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