INT108963

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2005
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.24
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNFRSF25) signal transduction (TNFRSF25) extracellular region (TNFRSF25)
plasma membrane (TNFRSF25)
Anatomy Link Frequency
lymphocytes 2
mononuclear cells 2
TNFRSF25 (Homo sapiens)
TNFRSF25 - L155V (1)
Pain Link Frequency Relevance Heat
Endogenous opioid 3 99.34 Very High Very High Very High
Inflammation 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 7 100.00 Very High Very High Very High
Apoptosis 18 98.90 Very High Very High Very High
Stress 8 94.80 High High
Lactic Acidosis 30 86.88 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 17 85.36 High High
Disease 1 80.88 Quite High
Toxicity 9 80.08 Quite High
Rheumatoid Arthritis 20 70.52 Quite High
Liver Failure 3 62.84 Quite High
Repression 4 48.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the effect of endogenous opioids was found to be exerted through increasing the expression of a cell death receptor, Fas, and an increased sensitivity of lymphocytes to apoptosis.
Positive_regulation (increasing) of Gene_expression (expression) of death receptor in lymphocytes associated with endogenous opioid, apoptosis and death
1) Confidence 0.42 Published 2003 Journal Brain Behav. Immun. Section Abstract Doc Link 12615182 Disease Relevance 0.95 Pain Relevance 0.27
Figure 6 shows that although wild-type DREAM causes activation of the DR3- and DR5-containing promoters, DREAM mutants bearing the mutations L47,52V in the first LCD or L155V in the second LCD did not activate basal or ligand-dependent expression of the DR3 and RAR?
Neg (not) Positive_regulation (activate) of Gene_expression (expression) of DR3 (L155V)
2) Confidence 0.37 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.07 Pain Relevance 0
In B-lymphoid cell types [38,39] and peripheral blood mononuclear cells [40], azidothymidine can trigger apoptosis and inhibition of the cell cycle [39] associated with overexpression of the death domain receptor Fas [40], although it is established that mitochondrial apoptosis can be responsible for an increased lactate production [41].


Positive_regulation (overexpression) of Gene_expression (overexpression) of death domain receptor in mononuclear cells associated with apoptosis and death
3) Confidence 0.05 Published 2003 Journal Crit Care Section Body Doc Link PMC270672 Disease Relevance 1.23 Pain Relevance 0

General Comments

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