INT108978

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 5.93
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CUX1) Golgi apparatus (CUX1) nucleolus (CUX1)
nucleus (CUX1) protein binding, bridging (CUX1) cytoplasm (CUX1)
Anatomy Link Frequency
lung 2
blood 1
spinal 1
chest 1
CUX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 7 99.16 Very High Very High Very High
Pain 2 99.10 Very High Very High Very High
c fibre 10 97.64 Very High Very High Very High
Action potential 2 96.04 Very High Very High Very High
Dorsal horn neuron 24 94.72 High High
Spinal cord 64 91.88 High High
Infliximab 4 91.16 High High
Dorsal horn 26 91.12 High High
spinal inflammation 1 85.60 High High
Etanercept 1 77.36 Quite High
Disease Link Frequency Relevance Heat
Delayed Puberty 16 100.00 Very High Very High Very High
Mycobacterial Infection 1 99.92 Very High Very High Very High
Hypogonadotropic Hypogonadism 10 99.76 Very High Very High Very High
Infection 5 98.96 Very High Very High Very High
Disease 8 98.84 Very High Very High Very High
Adult Respiratory Distress Syndrome 165 98.20 Very High Very High Very High
Systemic Lupus Erythematosus 1 98.04 Very High Very High Very High
Fistula 3 96.80 Very High Very High Very High
Lymphedema 5 95.20 Very High Very High Very High
Hypersensitivity 1 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although increases of the CDP may improve oxygenation and gas exchange, the effects of high CDP and nearly constant lung volumes during HFOV upon organ blood flow have not been evaluated.
Positive_regulation (increases) of CDP in blood
1) Confidence 0.57 Published 2006 Journal Crit Care Section Body Doc Link PMC1751024 Disease Relevance 0 Pain Relevance 0
During HFOV (High Frequency Oscillator Ventilator 3100b; Sensor Medics, Yorba Linda, CA, USA) the CDP (= Pmean) was increased in steps of 5 mbar from 20, to 25 and 30 mbar every 30 minutes.
Positive_regulation (increased) of CDP
2) Confidence 0.50 Published 2006 Journal Crit Care Section Body Doc Link PMC1751024 Disease Relevance 0 Pain Relevance 0
This research project lead by a nurse is underway using CDP in an outpatient department.
Positive_regulation (using) of CDP
3) Confidence 0.44 Published 2009 Journal Fukuoka Igaku Zasshi Section Abstract Doc Link 19670806 Disease Relevance 0.95 Pain Relevance 0.05
Current practice at the initiation of HFOV involves lung recruitment maneuvers, typically performed by increases of CDP in steps of 2–5 mbar up to 40 mbar [5-8].
Positive_regulation (increases) of CDP in lung
4) Confidence 0.38 Published 2006 Journal Crit Care Section Body Doc Link PMC1751024 Disease Relevance 0 Pain Relevance 0
The findings of an HFOV initiation protocol by stepwise increases of CDP can therefore only be compared with the used lung recruitment strategy by PCV with PEEP increases coupled to a constant inspiratory pressure amplitude (PEEP + 20 mbar).
Positive_regulation (increases) of CDP in lung
5) Confidence 0.38 Published 2006 Journal Crit Care Section Body Doc Link PMC1751024 Disease Relevance 0.34 Pain Relevance 0
As the flow increases, the CDPm approaches CDP8, leading to an LFC value of unity.
Positive_regulation (increases) of CDP8
6) Confidence 0.37 Published 2008 Journal Biomed Eng Online Section Body Doc Link PMC2556321 Disease Relevance 0.43 Pain Relevance 0
In those with serum T < 50 ng/ dl our data suggest that a single injection of HCG 15 IU/kg, with serum T determined 48 hours later, is more discriminatory and offers the most reliable, easy to perform, least painful, and by far the most cost effective test to differentiate CDP from HH.
Positive_regulation (differentiate) of CDP associated with pain, delayed puberty and hypogonadotropic hypogonadism
7) Confidence 0.23 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 16279369 Disease Relevance 0.79 Pain Relevance 0.10
The CDP is thereafter increased in a stepwise manner (2–5 mbar every 15–30 minutes) up to the maximum increase of PaO2 or up to a predetermined CDP.
Positive_regulation (increased) of CDP
8) Confidence 0.22 Published 2006 Journal Crit Care Section Body Doc Link PMC1751068 Disease Relevance 0.23 Pain Relevance 0
The LVOP increased the PaO2/FiO2 ratio from PCV post-lavage (99 (56–128) Torr) to CDP45 (621 (619–660) Torr) (P < 0.05).
Positive_regulation (increased) of CDP45
9) Confidence 0.18 Published 2006 Journal Crit Care Section Body Doc Link PMC1751068 Disease Relevance 0 Pain Relevance 0
For a given mean airway pressure (CDP) the pleural pressure increases if the chest wall elastance is elevated, and consequently the TPP decreases.
Positive_regulation (increases) of CDP in chest
10) Confidence 0.16 Published 2006 Journal Crit Care Section Body Doc Link PMC1751068 Disease Relevance 0.81 Pain Relevance 0
The PaCO2 increased from CDP45 (38.5 (28.3–46) Torr) to CDP20 (54.4 (40.7–68.6) Torr) (P < 0.001).


Positive_regulation (increased) of CDP45
11) Confidence 0.16 Published 2006 Journal Crit Care Section Body Doc Link PMC1751068 Disease Relevance 0 Pain Relevance 0
At a CDP of 45 mbar, the SV and CO were decreased and, simultaneously, the cardiac filling pressures (LVEDP, right atrial pressure, and PAOP) were elevated.
Positive_regulation (elevated) of CDP
12) Confidence 0.15 Published 2006 Journal Crit Care Section Body Doc Link PMC1751068 Disease Relevance 0.16 Pain Relevance 0
The CDP is then increased in a stepwise fashion (2–5 mbar steps) every 15–30 minutes until a maximum in PaO2 or a predetermined CDP is reached.
Positive_regulation (increased) of CDP
13) Confidence 0.15 Published 2006 Journal Crit Care Section Body Doc Link PMC1751068 Disease Relevance 0.07 Pain Relevance 0
PnA elicited CDP
Positive_regulation (elicited) of CDP
14) Confidence 0.12 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1131907 Disease Relevance 0 Pain Relevance 0.78
In summary, the present study recorded a spinal CDP elicited by the activation of phrenic nerve afferents.
Positive_regulation (elicited) of CDP in spinal
15) Confidence 0.11 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1131907 Disease Relevance 0 Pain Relevance 0.14
CDP571 is effective for treating active Crohn's disease, steroid sparing, and possibly for closing fistulas and maintaining remission.
Spec (possibly) Positive_regulation (effective) of CDP571 associated with fistula, crohn's disease and disease
16) Confidence 0.07 Published 2003 Journal Best Pract Res Clin Gastroenterol Section Abstract Doc Link 12617886 Disease Relevance 2.07 Pain Relevance 0.66
To change Pmean, continuous distending pressure (CDP) was elevated in steps of 3 cm H2O.

(6) T80: Pmean = 22 cmH2O. (7) T100: Pmean = 25 cmH2O. (8) T120: Pmean = 28 cmH2O. (9) T140: Pmean = 31 cmH2O. (10) T160: Pmean = 34 cmH2O. (11) T180: Pmean had been decreased to 16 cmH2O (?

Positive_regulation (elevated) of CDP
17) Confidence 0.01 Published 2006 Journal BMC Anesthesiol Section Body Doc Link PMC1450271 Disease Relevance 0.06 Pain Relevance 0

General Comments

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