INT10899

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2009
Negated 1
Speculated 3
Reported most in Abstract
Documents 32
Total Number 37
Disease Relevance 24.88
Pain Relevance 7.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
plasma 12
platelet 4
thoracic aorta 4
blood 4
endothelial cells 4
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 4 100.00 Very High Very High Very High
mu opioid receptor 2 99.24 Very High Very High Very High
Inflammation 18 98.88 Very High Very High Very High
Dopamine 4 98.80 Very High Very High Very High
Chronic pancreatitis 25 98.68 Very High Very High Very High
medulla 152 97.80 Very High Very High Very High
cytokine 10 97.40 Very High Very High Very High
fibrosis 5 97.00 Very High Very High Very High
ischemia 8 96.32 Very High Very High Very High
Nicotine 11 95.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ocular Hypertension 150 100.00 Very High Very High Very High
Injury 40 100.00 Very High Very High Very High
Hyperplasia 3 100.00 Very High Very High Very High
Nicotine Addiction 17 99.98 Very High Very High Very High
Fever 10 99.98 Very High Very High Very High
Diabetes Mellitus 1171 99.92 Very High Very High Very High
Hypertension 18 99.84 Very High Very High Very High
Myocardial Infarction 12 99.84 Very High Very High Very High
Sickle Cell Anemia 8 99.54 Very High Very High Very High
Cancer 39 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest that elevation in local production of ET-1 may be associated with the morphological and hemodynamic changes of CP.
Positive_regulation (elevation) of Gene_expression (production) of ET-1 associated with chronic pancreatitis
1) Confidence 0.70 Published 1996 Journal Pancreas Section Abstract Doc Link 8783339 Disease Relevance 0.45 Pain Relevance 0.41
These findings suggest that an elevation in local expression of endothelin-1 may be associated with the morphological and haemodynamic changes of chronic pancreatitis.
Positive_regulation (elevation) of Gene_expression (expression) of endothelin-1 associated with chronic pancreatitis
2) Confidence 0.69 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8778321 Disease Relevance 0.56 Pain Relevance 0.59
Northern blot analysis showed an increase in the expression of endothelin-1 mRNA in the patient population.
Positive_regulation (increase) of Gene_expression (expression) of endothelin-1 mRNA
3) Confidence 0.69 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8778321 Disease Relevance 0.65 Pain Relevance 0.65
In the absence of antiulcer agents, indomethacin caused multiple hemorrhagic lesions and extensive epithelial cell apoptosis, accompanied by a 20.7% reduction in IL-4, a 3.1-fold increase in mucosal expression of ET-1 and a 4.2-fold decline in cNOS.
Positive_regulation (increase) of Gene_expression (expression) of ET-1 in epithelial cell associated with apoptosis
4) Confidence 0.60 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10424717 Disease Relevance 0.62 Pain Relevance 0.11
A significant increase in the protein expression of preproET-1 of kidney cortex was observed in 28-days diabetes group as compared to 14-days diabetes and control groups (Fig 3C).
Positive_regulation (increase) of Gene_expression (expression) of preproET-1 in kidney cortex associated with diabetes mellitus
5) Confidence 0.60 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.23 Pain Relevance 0.11
In the present study, we also observed an elevated expression of preproET-1 proteins in aorta and kidney cortex but not in kidney medulla at 14-days and 28-days following diabetes induction.
Positive_regulation (elevated) of Gene_expression (expression) of preproET-1 in kidney medulla associated with medulla and diabetes mellitus
6) Confidence 0.60 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.03 Pain Relevance 0.05
These findings suggest that during early diabetes an upregulation of ET-1 biosynthesis in vascular (thoracic aorta) and locally at the organ level (kidney cortex) could be responsible for vascular and renal dysfunction seen during diabetes.
Positive_regulation (upregulation) of Gene_expression (biosynthesis) of ET-1 in thoracic aorta associated with diabetes mellitus and renal disease
7) Confidence 0.60 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.94 Pain Relevance 0.05
We also found a significant increase in the expression of preproET-1 in kidney cortex in 14-days diabetes groups as compared to control group.
Positive_regulation (increase) of Gene_expression (expression) of preproET-1 in kidney cortex associated with diabetes mellitus
8) Confidence 0.60 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.14 Pain Relevance 0.11
The expression of preproET-1 was significantly increased in thoracic aorta in 14-days and 28-days diabetes groups as compared to control group (Fig 3B).
Positive_regulation (increased) of Gene_expression (expression) of preproET-1 in thoracic aorta associated with diabetes mellitus
9) Confidence 0.60 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.22 Pain Relevance 0.11
The present study was undertaken to investigate whether intrastriatally injected ET-1 produces ischemic responses such as a decrease in the striatal blood flow and increases in extracellular lactate and dopamine levels in the neostriatum as seen in other models of ischemia.
Spec (whether) Positive_regulation (increases) of Gene_expression (produces) of ET-1 in blood associated with dopamine and ischemia
10) Confidence 0.50 Published 1991 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1725375 Disease Relevance 0.19 Pain Relevance 0.24
Rats were implanted with an osmotic pump delivering either ET-1 (24 ?
Positive_regulation (delivering) of Gene_expression (delivering) of ET-1
11) Confidence 0.50 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004627 Disease Relevance 0.22 Pain Relevance 0
ET-1 produced dose-dependent increases in skeletal muscle microvascular perfusion, whereas ET-1 had no effect on cutaneous microvascular perfusion, suggesting that vasodilation in the skeletal muscle of the hindlimb contributes to the increase in hindquarter blood flow induced by ET-1.
Positive_regulation (increases) of Gene_expression (produced) of ET-1 in hindlimb associated with increased venous pressure under development
12) Confidence 0.50 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2260707 Disease Relevance 0.17 Pain Relevance 0
ET-1 (0.01-300 pmol ia) produced only dose-dependent increases in hindquarter perfusion pressure under basal conditions or when the vascular preparation was precontracted with methoxamine.
Positive_regulation (increases) of Gene_expression (produced) of ET-1
13) Confidence 0.50 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2260707 Disease Relevance 0.17 Pain Relevance 0
ET-1 (10-100 pmol ia) produced brief dose-related increases in hindquarter blood flow.
Positive_regulation (increases) of Gene_expression (produced) of ET-1 in blood
14) Confidence 0.50 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2260707 Disease Relevance 0.14 Pain Relevance 0
In contrast, in females, exposure to endothelin-1 increased expression of both endothelin receptors and the mu opioid receptor in hindpaw skin.
Positive_regulation (increased) of Gene_expression (expression) of endothelin in skin associated with mu opioid receptor
15) Confidence 0.49 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19788914 Disease Relevance 0.05 Pain Relevance 1.15
The endothelin (ET)-1 levels in plasma and isolated glomeruli increased by about twofold in CAP-HS rats compared with CON-HS rats (P < 0.05).
Positive_regulation (increased) of Gene_expression (levels) of endothelin in plasma
16) Confidence 0.49 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15994858 Disease Relevance 0.97 Pain Relevance 0.10
Smoking increases production of platelet activating factor (PAF) and endothelin, which are potent gastric ulcerogens.
Positive_regulation (increases) of Gene_expression (production) of endothelin in platelet associated with nicotine addiction
17) Confidence 0.49 Published 2003 Journal Mol. Cell. Biochem. Section Abstract Doc Link 14619984 Disease Relevance 1.35 Pain Relevance 0.53
Cytokines seem to be involved with several possible mechanisms in the pathogenesis of vasoocclusive phenomena in SCD: vascular endothelial activation, induction of red-cell adhesiveness to vascular endothelium, induction of neutrophil adhesiveness to endothelium, development of vascular intimal hyperplasia, platelet activation, endothelin-1 production, and dysregulation of endothelial apoptosis.
Spec (possible) Positive_regulation (activation) of Gene_expression (production) of endothelin-1 in platelet associated with sickle cell anemia, apoptosis, hyperplasia and cytokine
18) Confidence 0.48 Published 2000 Journal Ann. Hematol. Section Abstract Doc Link 10985359 Disease Relevance 0.95 Pain Relevance 0.31
Baseline plasma endothelin-1 levels were higher (P < 0.0001) in ischaemic patients [1.81 pg mL-1 (0.15, n = 14)] than in control subjects [0.61 pg mL-1 (0.03, n = 14)], but did not increase with exercise in both groups.
Neg (not) Positive_regulation (increase) of Gene_expression (levels) of endothelin-1 in plasma
19) Confidence 0.48 Published 1997 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 9229234 Disease Relevance 0.32 Pain Relevance 0.07
These experiments usually use a single administration of ET-1, whereas in pathological conditions, such as cancer, patients have chronically (uninterrupted) elevated ET-1 levels in their plasma.
Positive_regulation (elevated) of Gene_expression (levels) of ET-1 in plasma associated with cancer
20) Confidence 0.47 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004627 Disease Relevance 1.16 Pain Relevance 0.39

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