INT108997

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Context Info
Confidence 0.77
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 28
Disease Relevance 3.76
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Htt) endoplasmic reticulum (Htt) mitochondrion organization (Htt)
embryo development (Htt) protein complex (Htt) cytoplasm (Htt)
Anatomy Link Frequency
neurons 7
neuronal 3
dendrites 2
brain 2
cortex 2
Htt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 1 100.00 Very High Very High Very High
Serotonin 5 99.72 Very High Very High Very High
monoamine 1 99.08 Very High Very High Very High
imagery 158 98.72 Very High Very High Very High
Dopamine 1 98.64 Very High Very High Very High
dopamine receptor 2 94.04 High High
Enkephalin 1 92.40 High High
Hippocampus 52 92.08 High High
substance P 1 91.92 High High
projection neuron 1 89.84 High High
Disease Link Frequency Relevance Heat
Disease 458 94.96 High High
General Immunology 26 91.72 High High
Alcohol Addiction 32 90.28 High High
Alcoholic Liver Diseases 41 76.36 Quite High
Death 79 64.60 Quite High
Neurodegenerative Disease 52 64.44 Quite High
Dementia 26 64.20 Quite High
Drug Dependence 3 63.68 Quite High
Hypersensitivity 104 55.32 Quite High
Frailty 26 53.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The yellow channel represents co-localizing puncta of BDNF mRNA and Htt, the magenta channel co-localizing puncta of BDNF mRNA and Ago2, and the cyan channel co-localizing Htt and Ago2.
Localization (localizing) of Htt
1) Confidence 0.77 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
The seventh pseudo channel is shown in panel d: white signal is the color addition product of three primary colors green, red and blue, representing the co-localization of Htt, BDNF mRNA and Ago2.
Localization (localization) of Htt
2) Confidence 0.77 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
To study the co-localization of Htt and associated proteins with specific mRNAs in the brain, we used immunofluorescence staining (IFS) and FISH.
Localization (localization) of Htt in brain
3) Confidence 0.77 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0.04
Co-localization of Htt with BDNF-3'UTR mRNA in cortical neurons
Localization (localization) of Htt in neurons
4) Confidence 0.77 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
The yellow channel represents co-localizing puncta of BDNF mRNA and Htt, the magenta channel co-localizing puncta of BDNF mRNA and Ago2, and the cyan channel co-localizing Htt and Ago2.
Localization (localizing) of Htt
5) Confidence 0.77 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
To localize Htt and BDNF mRNA, rat cortical neurons (DIV 8) were stained for endogenous Htt with an antibody to Htt (MAB2166, Millipore).
Localization (localize) of Htt in neurons
6) Confidence 0.77 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.19 Pain Relevance 0
Neurosci., 16 (1996) 6579-6591] co-localized with huntingtin in a higher proportion than striatonigral neurons.
Localization (co-localized) of huntingtin in neurons
7) Confidence 0.73 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12618299 Disease Relevance 0.20 Pain Relevance 0.23
Visualization of Htt, CPEB1, dynein with BDNF mRNA
Localization (Visualization) of Htt
8) Confidence 0.72 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
We found BDNF mRNA to co-localize with Htt in granules, consistent with our previous finding that Htt is present in neuronal RNA granules and co-localizes with mRNAs [10].


Localization (localize) of Htt in neuronal
9) Confidence 0.72 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.10 Pain Relevance 0
Visualization of Htt, Ago2 with BDNF mRNA
Localization (Visualization) of Htt
10) Confidence 0.72 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0.05
We have utilized our improved approach to study the co-localization of the proteins Htt, Ago2, cytoplasmic polyadenylation element-binding protein 1 (CPEB1) and dynein, with BDNF mRNA as described below.


Localization (localization) of Htt
11) Confidence 0.72 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0.04
We previously reported that Htt co-localizes with Ago2 in processing (P)-bodies of somatic cells and neuronal granules [9,10] suggesting that Htt may play a role in RNA processing and/or gene silencing.
Localization (localizes) of Htt in neuronal
12) Confidence 0.72 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.42 Pain Relevance 0
In dendrites, Htt co-localizes with components of neuronal granules and mRNAs, indicating that it might play a role in post-transcriptional processing/transport of dendritic mRNAs.


Localization (localizes) of Htt in neuronal
13) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC2889995 Disease Relevance 0.16 Pain Relevance 0.04
We conducted imaging experiments in cultured cortical neurons to demonstrate the co-localization of endogenous Htt and BDNF mRNA in fixed cells, and co-trafficking of BDNF 3'UTR mRNA with endogenous and fluorescently tagged Htt in live neurons.
Localization (localization) of Htt in neurons associated with imagery
14) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC2889995 Disease Relevance 0.15 Pain Relevance 0.05
We show that the 3'UTR of BDNF mRNA and Htt co-localize and co-traffic in cortical neurons.
Localization (localize) of Htt in neurons
15) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
Quantitative analysis of one projection from the CPEB1 image stack was as follows: 37.6% of BDNF mRNA co-localized with CPEB1, 17.1% of CPEB1 co-localized with BDNF mRNA, 20.0% of Htt co-localized with CPEB1, and 22.0% CPEB1 co-localized with Htt.
Localization (localized) of Htt
16) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
The 3D temporal and spatial relationship and the co-localization of individual BDNF mRNA-containing granules with Htt and CPEB1 in vibratome sections were demonstrated by high-resolution reconstruction (Fig. 5c and additional file 3).
Localization (localization) of Htt
17) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
We used an enhanced technique that combines FISH and immunofluorescent staining to co-localize BDNF mRNA with Htt, Ago2, CPEB and dynein in thick vibratome sections of the rat cortex.


Localization (localize) of Htt in cortex
18) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC2889995 Disease Relevance 0.14 Pain Relevance 0.04
We have also demonstrated that the 3'UTR of BDNF mRNA and Htt co-localize and co-traffic in cortical neurons.
Localization (localize) of Htt in neurons
19) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
To localize Htt and BDNF mRNA, rat cortical neurons (DIV 8) were stained for endogenous Htt with an antibody to Htt (MAB2166, Millipore).
Localization (localize) of Htt in neurons
20) Confidence 0.62 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.19 Pain Relevance 0

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