INT109

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Context Info
Confidence 0.47
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 3.02
Pain Relevance 3.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ADRB3) aging (ADRB3) plasma membrane (ADRB3)
nucleus (ADRB3) carbohydrate metabolic process (ADRB3) signal transducer activity (ADRB3)
Anatomy Link Frequency
myometrium 1
urinary bladder 1
plasma 1
CAR 1
thickening 1
ADRB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 2 100.00 Very High Very High Very High
antagonist 53 99.96 Very High Very High Very High
lidocaine 20 99.92 Very High Very High Very High
Mexiletine 16 99.76 Very High Very High Very High
Chronic pancreatitis 1 98.72 Very High Very High Very High
adenocard 10 98.32 Very High Very High Very High
agonist 169 96.28 Very High Very High Very High
addiction 2 94.72 High High
Angina 3 92.12 High High
IPN 3 90.56 High High
Disease Link Frequency Relevance Heat
Cancer 2 99.22 Very High Very High Very High
Pancreatitis 1 98.72 Very High Very High Very High
Premature Birth 25 98.20 Very High Very High Very High
Pancreatic Cancer 5 97.74 Very High Very High Very High
Hypertrophy 2 97.70 Very High Very High Very High
Increased Venous Pressure Under Development 6 96.08 Very High Very High Very High
Overactive Bladder 4 94.64 High High
Congenital Anomalies 1 92.60 High High
Cv General 3 Under Development 2 92.12 High High
Hypersensitivity 2 88.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High concentration (100 microM-1 mM) of mexiletine partially displaced the specific binding of [125I]cyanopindolol to human beta3-adrenoceptor.
beta3-adrenoceptor Binding (binding) of associated with mexiletine
1) Confidence 0.47 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15104234 Disease Relevance 0 Pain Relevance 0.43
On the other hand, high concentration (300 microM and 1 mM) of lidocaine, another class Ib antiarrhythmic drug, partially displaced the specific binding of [125I]cyanopindolol to human beta1-adrenoceptor, whereas it did not affect the specific binding of [125I]cyanopindolol to human beta2- and beta3-adrenoceptors.
beta3-adrenoceptor Binding (binding) of associated with lidocaine
2) Confidence 0.47 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15104234 Disease Relevance 0 Pain Relevance 0.56
Significant correlations were found between log NK and log partition coefficient octanol-phosphate buffer suggesting that the protein binding of the 9 adrenergic beta-receptor antagonists to all serum proteins, including alpha 1-AGP, is predominantly hydrophobic in nature.
adrenergic beta-receptor Binding (binding) of associated with antagonist
3) Confidence 0.42 Published 1982 Journal Biochem. Pharmacol. Section Abstract Doc Link 6122452 Disease Relevance 0 Pain Relevance 0.18
This case supports the potential lethality of a cocaine-beta adrenergic receptor antagonist interaction.


beta adrenergic receptor Binding (interaction) of
4) Confidence 0.39 Published 2007 Journal J Med Toxicol Section Body Doc Link 18072171 Disease Relevance 0.05 Pain Relevance 0
Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?


ADRB3 Binding (target) of
5) Confidence 0.37 Published 2007 Journal BMC Pregnancy Childbirth Section Title Doc Link PMC1892055 Disease Relevance 0.10 Pain Relevance 0.07
Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?


beta3-adrenoceptor Binding (target) of
6) Confidence 0.37 Published 2007 Journal BMC Pregnancy Childbirth Section Title Doc Link PMC1892055 Disease Relevance 0.10 Pain Relevance 0.07
Binding competition studies, transcripts and protein analysis were then performed to determine whether any changes in the number of ADRB2 and ADRB3 binding sites and in the transcript and protein expression might explain the observed change in the contractile response between non-pregnant and pregnant myometrium to ADRB2 and ADRB3 agonists.
ADRB3 Binding (binding) of in myometrium associated with agonist
7) Confidence 0.37 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.07
Detailed pharmacological studies with propranolol and comparison of its properties with those of other beta-adrenoceptor blocking drugs have indicated that these drugs may possess properties in addition to their effect in blocking beta-adrenoceptors.
beta-adrenoceptor Binding (effect) of
8) Confidence 0.37 Published 1976 Journal Postgrad Med J Section Abstract Doc Link 9628 Disease Relevance 0.09 Pain Relevance 0.13
ADRB2 [20-23] and the presence of ADRB3 had never been studied prior to our investigations presented here.
ADRB3 Binding (presence) of
9) Confidence 0.36 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0.33 Pain Relevance 0.18
The inotropic effect of both enoximone and dobutamine is obtained via the same final biochemical pathway (an increase in intracellular cyclic adenosine monophospate) but by means of different mechanisms: enoximone acts distally to the beta-adrenoceptor, and binds directly and selectively to the intracellular enzyme phosphodiesterase III that specifically degrades cardiac cyclic adenosine monophosphate.
beta-adrenoceptor Binding (binds) of associated with adenocard
10) Confidence 0.35 Published 2003 Journal Cardiovasc Ultrasound Section Body Doc Link PMC240109 Disease Relevance 0.34 Pain Relevance 0.13
To conclude, our work strongly suggests the ADRB3 as a potential target for tocolytic agents.
ADRB3 Binding (target) of
11) Confidence 0.33 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.29
Characterization of beta-adrenoceptor subtypes in the ferret urinary bladder in vitro and in vivo.
beta-adrenoceptor Binding (Characterization) of in urinary bladder associated with anesthesia
12) Confidence 0.31 Published 2000 Journal Eur. J. Pharmacol. Section Title Doc Link 10969156 Disease Relevance 0.18 Pain Relevance 0.31
To further locate the site of impaired cAMP responses, beta-adrenoceptor binding, as well as displacement characteristics of the receptor, were estimated by 125I-cyanopindolol binding to a plasma membrane fraction pretreated with or without PT.
beta-adrenoceptor Binding (binding) of in plasma
13) Confidence 0.22 Published 1990 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 2164475 Disease Relevance 0.37 Pain Relevance 0.27
Effect of pH and lidocaine on beta-adrenergic receptor binding.
beta-adrenergic receptor Binding (binding) of associated with lidocaine
14) Confidence 0.12 Published 1995 Journal Chest Section Title Doc Link 7587445 Disease Relevance 0.09 Pain Relevance 0.57
Surgery confirmed pancreatic cancer in 3 out of the 5 patients (chronic pancreatitis and periampullary cancer in one each); in all these 3 patients immunostaining with the MoAb AR-3 demonstrated the presence of the CAR-3 antigen (with a cytoplasmic and endoluminal/secretory pattern of distribution).
AR-3 Binding (immunostaining) of in CAR associated with cancer, pancreatic cancer and chronic pancreatitis
15) Confidence 0.12 Published 1994 Journal J Nucl Biol Med Section Abstract Doc Link 7632759 Disease Relevance 0.61 Pain Relevance 0.10
It could not readily be attributed to intimal thickening or hypertrophy of the arterial wall, altered basal levels of norepinephrine or epinephrine, changes in norepinephrine clearance, beta-adrenoceptor interactions, or decreased baroreceptor sensitivity.
beta-adrenoceptor Binding (interactions) of in thickening associated with hypertrophy
16) Confidence 0.06 Published 1983 Journal Hypertension Section Abstract Doc Link 6317553 Disease Relevance 0.75 Pain Relevance 0.27
Binding constants for ascorbate binding to beta adrenergic receptor were derived from concentration-dependent spectral shifts.
beta adrenergic receptor Binding (binding) of
17) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001466 Disease Relevance 0 Pain Relevance 0.21

General Comments

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