INT10900

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Context Info
Confidence 0.41
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.53
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Nppb) extracellular region (Nppb) nucleus (Nppb)
cytoplasm (Nppb)
Anatomy Link Frequency
plasma 6
renal proximal tubule 2
Nppb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 11 70.60 Quite High
rheumatoid arthritis 32 61.28 Quite High
anesthesia 3 25.00 Low Low
cINOD 7 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 96 99.76 Very High Very High Very High
Ocular Hypertension 120 98.72 Very High Very High Very High
Obesity 8 95.84 Very High Very High Very High
Natriuresis 16 94.44 High High
Pulmonary Hypertension 8 92.48 High High
Cardiovascular Disease 24 92.04 High High
INFLAMMATION 13 70.60 Quite High
Heart Rate Under Development 9 70.12 Quite High
Disease 34 64.28 Quite High
Arthritis 3 63.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma levels of BNP have been found to increase during hypoxia.[20] In addition to extended exposure to hypobaric hypoxia itself (10-91 days), endurance training in hypobaric hypoxic conditions leads to a marked early increase in ventricular and atrial BNP mRNA levels.[21] As for the physiologic effects that can be produced by elevated plasma BNP levels, Klinger et al., found that in rats, BNP infusion attenuated the development of hypoxic pulmonary hypertension.[22] The authors suggested that this finding supports the hypothesis that endogenous BNP plays a role in modulating the pulmonary hypertensive responses seen in chronic hypoxia.
Positive_regulation (leads) of Positive_regulation (increase) of BNP in plasma associated with pulmonary hypertension and hypoxia
1) Confidence 0.41 Published 2010 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2886248 Disease Relevance 1.31 Pain Relevance 0
Short-term hypobaric hypoxic exposure did not cause an increase in plasma BNP levels, probably the increased IOP levels are compensated by some local or systemic factors other than BNP levels.
Neg (not) Positive_regulation (cause) of Positive_regulation (increase) of BNP in plasma associated with hypoxia and ocular hypertension
2) Confidence 0.41 Published 2010 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2886248 Disease Relevance 1.17 Pain Relevance 0
NT-proBNP is metabolized in the renal proximal tubule, and reduced renal function partially accounts for the age-related increase in NT-proBNP levels in the general population [14,35].
Positive_regulation (accounts) of Positive_regulation (increase) of NT-proBNP in renal proximal tubule
3) Confidence 0.40 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 0.87 Pain Relevance 0.21
A bolus injection of AVP induced a dose-dependent increase in plasma immunoreactive (ir)-BNP concentration in rats.
Positive_regulation (induced) of Positive_regulation (increase) of BNP in plasma
4) Confidence 0.37 Published 1992 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 1526063 Disease Relevance 0.17 Pain Relevance 0

General Comments

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