INT109005

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 61
Total Number 61
Disease Relevance 37.86
Pain Relevance 8.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Proc) extracellular space (Proc) extracellular region (Proc)
Anatomy Link Frequency
joints 3
placodes 3
tongue 2
lung 2
parathyroid 2
Proc (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 26 100.00 Very High Very High Very High
rheumatoid arthritis 250 99.80 Very High Very High Very High
trigeminal ganglion 540 99.68 Very High Very High Very High
Arthritis 231 99.60 Very High Very High Very High
Inflammation 696 99.48 Very High Very High Very High
Nerve growth factor 149 99.10 Very High Very High Very High
Pain 46 96.08 Very High Very High Very High
opioid receptor 19 95.28 Very High Very High Very High
nociceptor 254 92.04 High High
bDMF 735 90.32 High High
Disease Link Frequency Relevance Heat
Acute-phase Reaction 6 100.00 Very High Very High Very High
Cancer 1029 99.98 Very High Very High Very High
Injury 246 99.96 Very High Very High Very High
Rheumatoid Arthritis 250 99.80 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 53 99.70 Very High Very High Very High
Ganglion Cysts 1257 99.68 Very High Very High Very High
Arthritis 273 99.60 Very High Very High Very High
Metastasis 529 99.58 Very High Very High Very High
Neurodegenerative Disease 44 99.58 Very High Very High Very High
Repression 50 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results show that brief TO during late gestation in fetal mice induces accelerated lung development with minimal effects on surfactant protein C mRNA expression.
Gene_expression (expression) of protein C in lung
1) Confidence 0.75 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12618424 Disease Relevance 0.16 Pain Relevance 0.06
In vivo tracheal occlusion in fetal mice induces rapid lung development without affecting surfactant protein C expression.
Gene_expression (expression) of protein C in lung
2) Confidence 0.75 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Title Doc Link 12618424 Disease Relevance 0.12 Pain Relevance 0.08
However, in situ hybridization showed no significant difference in the density of type II pneumocytes expressing surfactant protein C mRNA.
Gene_expression (expressing) of protein C in pneumocytes
3) Confidence 0.75 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12618424 Disease Relevance 0.18 Pain Relevance 0.07
Pancreatic (trypsin I and II) and extrapancreatic (trypsin IV) trypsins, mast cell tryptase and coagulation factors VIIa and Xa cleave and activate PAR(2).
Gene_expression (cleave) of coagulation factors VIIa in mast cell
4) Confidence 0.22 Published 2003 Journal Biochem. Soc. Trans. Section Abstract Doc Link 14641024 Disease Relevance 0.34 Pain Relevance 0.22
Furthermore, antiangiogenic effects could be observed in both studies with a reduced microvessel density and altered expression levels of angiogenesis-related factors like FLT-1, Neuropillin-2 and VEGF-C, respectively [97, 98].
Gene_expression (expression) of factors
5) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 1.33 Pain Relevance 0
Both the therapy with SB431542 as well as tumors transduced with the inhibitory protein SMAD-7, showed significantly less osteolyses, longer survival and lower expression levels of osteolytic factors such as parathyroid hormone-related protein and interleukin-11 [96].
Gene_expression (expression) of factors in parathyroid associated with cancer and osteolysis
6) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 1.04 Pain Relevance 0
PU.1 is a member of the ets family of transcription factors, expressed predominantly in hematopoietic cells and microglia of brain.
Gene_expression (expressed) of factors in brain
7) Confidence 0.02 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14998994 Disease Relevance 0 Pain Relevance 0.49
Only transcriptional factors exhibiting a ratio greater than 3.0 between control and treated groups are being presented.


Gene_expression (presented) of factors
8) Confidence 0.01 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0 Pain Relevance 0
Thus, the upregulation of PGE2 by PK might contribute to its healing activity primarily via increasing the levels of mucin, and other growth factors, and to a lesser extent due to inhibition to gastric secretion.
Gene_expression (levels) of factors
9) Confidence 0.01 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.28 Pain Relevance 0
PK (20 mg/kg, p. o. × 3 days) could effectively heal indomethacin-induced stomach ulceration in mice by reducing oxidative stress, and promoting mucin secretion, prostaglandin synthesis and augmenting expressions of cyclooxygenase enzymes and growth factors.



Gene_expression (expressions) of factors in stomach associated with stress
10) Confidence 0.01 Published 2008 Journal BMC Complement Altern Med Section Abstract Doc Link PMC2266895 Disease Relevance 0.16 Pain Relevance 0
blocks expression of prometastatic factors VEGF and CXCR4 in MDA-MB-231 cells.
Gene_expression (expression) of factors in MDA-MB-231
11) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.40 Pain Relevance 0
in the bone microenvironment enhance tumor production of factors that drive the feed-forward cycle of bone metastasis.
Gene_expression (production) of factors associated with cancer and metastasis
12) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.66 Pain Relevance 0.13
in bone [2] promotes bone metastases by increasing tumor production of factors that stimulate osteoclastic bone resorption and tumor growth [6], [7].
Gene_expression (production) of factors associated with cancer, hypercalcemia, osteoporosis and metastasis
13) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 2.12 Pain Relevance 0.07
Together these data show that Brn3a creates a permissive condition for the expression of the Runx factors, which then repress TrkB expression and allow differentiation of the principal sensory subtypes.


Gene_expression (expression) of factors
14) Confidence 0.01 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.35 Pain Relevance 0.29
The mature expression pattern of these sensory markers is not complete until the second postnatal week, but we were able to assess the expression of several of these factors in the TG of P0 Brn3a-/- mice.
Gene_expression (expression) of factors associated with trigeminal ganglion
15) Confidence 0.01 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.39 Pain Relevance 1.08
Maturation of these sensory subtypes is known to depend on the expression of Runx transcription factors.
Gene_expression (expression) of factors
16) Confidence 0.01 Published 2010 Journal Neural Dev Section Abstract Doc Link PMC2829025 Disease Relevance 0.60 Pain Relevance 0.34
Prior work has shown that Brn3a is necessary to terminate the expression of early neurogenic transcription factors such as Neurod1 and Neurod4 in the developing TG.
Gene_expression (expression) of factors associated with trigeminal ganglion
17) Confidence 0.01 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.47 Pain Relevance 0.16
However, direct regulation has been demonstrated only for bHLH transcription factors that are expressed early in sensory neurogenesis and subsequently repressed by Brn3a [14], and a direct transcriptional activator function has not been demonstrated for Brn3a in vivo.
Gene_expression (expressed) of factors associated with neurodegenerative disease
18) Confidence 0.01 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.53 Pain Relevance 0.03
In the DRG and TG, Brn3a facilitates the progression of sensory development by terminating the expression of neurogenic bHLH factors by direct repression [13,14], and a similar role has been described for Islet1 [15], defining one common function for these pan-sensory factors.
Gene_expression (expression) of factors associated with trigeminal ganglion and repression
19) Confidence 0.01 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.46 Pain Relevance 0.28
Sensory neurogenesis is dependent on the expression of the basic helix-loop-helix (bHLH) transcription factors Neurog1 and Neurog2 [4,5].
Gene_expression (expression) of factors associated with neurodegenerative disease
20) Confidence 0.01 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.41 Pain Relevance 0.54

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