INT109007

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 9.50
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Anatomy Link Frequency
BxPC-3 2
lungs 2
bronchioles 1
apoptotic cell 1
epithelial cells 1
Ccnd1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 10 99.40 Very High Very High Very High
Inflammation 102 99.12 Very High Very High Very High
chemokine 4 79.84 Quite High
cytokine 33 78.72 Quite High
Inflammatory response 16 75.00 Quite High
Chronic pancreatitis 3 69.40 Quite High
cINOD 19 63.60 Quite High
aspirin 13 50.00 Quite Low
addiction 3 45.00 Quite Low
Spinal cord 4 40.20 Quite Low
Disease Link Frequency Relevance Heat
Carcinoma 11 99.80 Very High Very High Very High
Cancer 490 99.68 Very High Very High Very High
Parathyroid Cancer 40 99.50 Very High Very High Very High
Death 55 99.18 Very High Very High Very High
INFLAMMATION 122 99.12 Very High Very High Very High
Apoptosis 206 98.96 Very High Very High Very High
Meningioma 91 98.88 Very High Very High Very High
Hyperplasia 21 97.12 Very High Very High Very High
Adenoma 6 95.40 Very High Very High Very High
Ovarian Cancer 34 95.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative real time RT-PCR performed using total RNA isolated from whole left lobes demonstrated that cyclin D1 mRNA was increased 1.3-fold in lungs from adult CCSPrtTA/tetO-Sox17 mice exposed to Dox for 1 day (data not shown).
Positive_regulation (increased) of cyclin D1 in lungs
1) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Staining for cyclin D1 was markedly increased in bronchioles and alveolar type II cells of CCSPrtTA/tetO-Sox17 mice following 2 days exposure to Dox (Fig. 6A–B).
Positive_regulation (increased) of cyclin D1 in bronchioles
2) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Thus, cyclin D1 mRNA and protein levels were significantly increased in lungs from CCSPrtTA/tetO-Sox17 mice just prior to the onset of proliferation, consistent with the concept that cyclin D1 contributes to the cell cycle reentry of mature respiratory epithelial cells following expression of Sox17.
Positive_regulation (increased) of cyclin D1 in epithelial cells
3) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
At embryonic day 16.5, pregnant CD1 mice were operated under general anesthesia.
Positive_regulation (operated) of CD1 associated with anesthesia
4) Confidence 0.45 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12618424 Disease Relevance 0.12 Pain Relevance 0.10
A well-conserved consensus Sox binding sequence was identified in cyclin D1 proximal promoter, located at approximately ?
Positive_regulation (identified) of cyclin D1 in proximal
5) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Consistent with the induction of proliferation observed by immunohistochemistry (Fig. 3), transcripts for genes that promote cell cycle progression, including Foxm1, cyclin A2, cyclin B1, cyclin D1, and cyclin E1, were increased in lungs of CCSPrtTA/tetO-Sox17 mice after 3 days of Dox treatment (Fig. 5).
Positive_regulation (increased) of cyclin D1 in lungs
6) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Our data shows that the ability of Sox17 to induce progenitor cell behavior is mediated, at least in part, by activating cyclin D1 and decreasing TGF-?
Positive_regulation (activating) of cyclin D1
7) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.13 Pain Relevance 0
Since cyclin D1 is a key regulator of progression through the G1 phase of the cell cycle and was increased in lungs from CCSPrtTA/tetO-Sox17 mice, we sought to determine if it was a direct downstream target of Sox17 during induction of respiratory epithelial cell proliferation.
Positive_regulation (increased) of cyclin D1 in respiratory
8) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Although the two pathways share transcriptional responsiveness of proliferative target genes, such as c-myc and cyclinD1, IL11 administration and excessive Stat3 activation also facilitates survival of epithelial cells with the capacity to repopulate the intestine after radiation damage [92] (Phesse T, Buchert M, Ernst M: Epistatic interaction between aberrant Wnt and Stat3 signaling during intestinal tumorigenesis, submitted).
Positive_regulation (responsiveness) of cyclinD1 in intestine
9) Confidence 0.23 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.37 Pain Relevance 0
In addition, inflammation associated with PAR2 stimulation led to an up-regulation of serpine 1, WT1, cyclin D1, IGF1R, and cathepsin K.


Positive_regulation (up-regulation) of cyclin D1 associated with inflammation
10) Confidence 0.19 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.30 Pain Relevance 0.15
Also with immunohistochemistry, parathyroid carcinoma cells showed a variable staining for CD1 and carcinoma cells strongly positive from CD1 mRNA varied with only weakly stained tumor cells (Figure 5).
Positive_regulation (staining) of CD1 in parathyroid associated with cancer, parathyroid cancer and carcinoma
11) Confidence 0.18 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2627811 Disease Relevance 1.16 Pain Relevance 0
Thus, the synergy we observed between Nf2 and p16Ink4 mutations in meningioma development reflects the concomitant loss of two regulators of CDK4 activity resulting in cyclin D1 activation.
Positive_regulation (activation) of cyclin D1 associated with meningioma
12) Confidence 0.14 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.20 Pain Relevance 0
At later timepoints, some mice showed focal areas of acinar cell damage with upregulated mRNA levels for Cyclin D1 and p16(INK4a).
Positive_regulation (upregulated) of Cyclin D1 in acinar cell
13) Confidence 0.13 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17546589 Disease Relevance 0.55 Pain Relevance 0.26
Despite the increased mRNA level, cyclin D1 protein levels were downregulated.
Positive_regulation (increased) of cyclin D1
14) Confidence 0.13 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17546589 Disease Relevance 0.55 Pain Relevance 0.26
These changes of CUGBP1 phosphorylation in DM1 myogenesis lead to the increase of cyclin D1 in DM1 myoblasts and to the reduction p21 in DM1 myotubes [68] (Fig. 7).
Positive_regulation (increase) of cyclin D1 in myoblasts
15) Confidence 0.13 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.08 Pain Relevance 0
In addition, VPA induced alterations in the expression of other cell cycle-related proteins, such as p27 and cyclin D1.
Positive_regulation (induced) of cyclin D1
16) Confidence 0.11 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.59 Pain Relevance 0
It is not clear from our studies that celecoxib directly affects cell cycle distribution by regulating cyclin D1 levels, which is one of the major cyclins known to be upregulated during cancer.
Positive_regulation (upregulated) of cyclin D1 associated with cancer
17) Confidence 0.10 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.81 Pain Relevance 0.06
However, our results could be explained, at least in part, by the fact that levels of the antiapoptotic-associated proteins such as activated AKT, Bcl-2, Bcl-xL and surviving, as well as the cell cycle-associated protein cyclin D1, were strongly decreased (Figure 7) indicating that apoptosis and cell cycle are regulated by reg4.
Positive_regulation (activated) of cyclin D1 associated with apoptosis
18) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760775 Disease Relevance 0.95 Pain Relevance 0
For example, Shh signaling upregulates cyclin D1, leading to cell proliferation promotion [13].
Positive_regulation (upregulates) of cyclin D1
19) Confidence 0.08 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.55 Pain Relevance 0.03
The blockage of EGFR and STAT3-signaling cascades seemingly increased the levels of p53, Bax and decreased levels of Bcl-xL, survivin, and cyclin D1 proteins.
Positive_regulation (increased) of cyclin D1
20) Confidence 0.07 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 1.12 Pain Relevance 0

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