INT109015

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.04
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKG1) signal transduction (PRKG1) plasma membrane (PRKG1)
cytoplasm (PRKG1)
Anatomy Link Frequency
medulla 2
colon 2
cell body 2
PRKG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Rostral ventrolateral medulla 55 98.86 Very High Very High Very High
medulla 13 98.72 Very High Very High Very High
hyperexcitability 3 98.22 Very High Very High Very High
potassium channel 1 92.48 High High
Morphine 1 91.36 High High
bradykinin 5 91.16 High High
Action potential 9 90.08 High High
Spinal cord 3 89.84 High High
agonist 90 89.12 High High
Opioid 3 87.56 High High
Disease Link Frequency Relevance Heat
Apoptosis 8 98.68 Very High Very High Very High
Colon Cancer 6 98.16 Very High Very High Very High
Death 63 96.28 Very High Very High Very High
Injury 4 93.68 High High
Cancer 3 76.00 Quite High
Hyperalgesia 1 75.00 Quite High
INFLAMMATION 4 74.84 Quite High
Cv Unclassified Under Development 5 74.56 Quite High
Nociception 3 72.12 Quite High
Ganglion Cysts 3 62.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacologic activation of PKG with YC-1 increases JNK phosphorylation and induces apoptosis in colon cancer cells without modulating ERK1/2 phosphorylation or beta-catenin protein expression.
Positive_regulation (increases) of Positive_regulation (activation) of PKG in colon associated with colon cancer and apoptosis
1) Confidence 0.38 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 1.12 Pain Relevance 0.14
NO, in turn, activates the soluble form of guanylate cyclase (sGC) leading to a rise in intracellular cGMP and activation of PKG [52–55].
Positive_regulation (leading) of Positive_regulation (activation) of PKG
2) Confidence 0.21 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04
Hence, the upregulation of PKG-I might possibly be mediated by cGMP itself.
Spec (might) Positive_regulation (mediated) of Positive_regulation (upregulation) of PKG
3) Confidence 0.09 Published 2003 Journal Nitric Oxide Section Abstract Doc Link 12620371 Disease Relevance 0.20 Pain Relevance 0.37
Underlying the hyperexcitability was an upregulation of nNOS, stimulation of which, apparently at the level of the axon, led to local activation of PKG which then was transported to the neuronal cell body.
Positive_regulation (led) of Positive_regulation (activation) of PKG in cell body associated with hyperexcitability
4) Confidence 0.06 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.28 Pain Relevance 0.32
The resulting nitric oxide activates soluble guanylyl cyclase resulting in cyclic C-GMP-dependent protein kinase (PKG) activation through production of cyclic guanosine monophosphate.
Positive_regulation (resulting) of Positive_regulation (activation) of PKG
5) Confidence 0.04 Published 2008 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18375591 Disease Relevance 0.07 Pain Relevance 0.63
Western blot analysis again revealed that microinjection bilaterally into RVLM of an effective dose of CGP57380 (5 pmol) significantly blunted the elevated NOS I or PKG protein level at ventrolateral medulla during the pro-life phase of experimental brain stem death (fig. 3), without affecting the increase of NOS II or nitrotyrosine protein expression (fig. 4).


Positive_regulation (blunted) of Positive_regulation (elevated) of PKG in medulla associated with medulla, rostral ventrolateral medulla and death
6) Confidence 0.04 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.37 Pain Relevance 0.36

General Comments

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