INT109021

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.13
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)
Anatomy Link Frequency
muscle 2
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 60 99.72 Very High Very High Very High
cytokine 7 99.12 Very High Very High Very High
Cholecystokinin 2 98.08 Very High Very High Very High
metalloproteinase 5 97.74 Very High Very High Very High
cINOD 2 92.00 High High
Inflammation 17 91.16 High High
Hyperalgesia 3 90.48 High High
Eae 2 75.00 Quite High
allodynia 1 66.88 Quite High
Neuropathic pain 1 62.56 Quite High
Disease Link Frequency Relevance Heat
Disease 3 98.32 Very High Very High Very High
Pancreatitis 10 97.64 Very High Very High Very High
Hyperglycemia 4 96.28 Very High Very High Very High
INFLAMMATION 18 91.76 High High
Hyperalgesia 3 90.48 High High
Necrosis 10 89.92 High High
Cancer 95 89.56 High High
Stress 18 86.88 High High
Infection 1 86.40 High High
Injury 3 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to establish whether methylprednisolone pretreatment is beneficial and if it can block the pancreatic DNA binding of the transcription factor nuclear factor-kappaB (NF-kappaB) and proinflammatory cytokine synthesis during cholecystokinin-octapeptide (CCK)-induced acute pancreatitis in rats.
Negative_regulation (block) of NF-kappaB Binding (binding) of associated with pancreatitis, cholecystokinin and cytokine
1) Confidence 0.39 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.47 Pain Relevance 0.23
In cell culture experiments, S1627 inhibited interleukin (IL)-1beta-stimulated nuclear translocation and DNA-binding of NF-kappaB.
Negative_regulation (inhibited) of NF-kappaB Binding (binding) of
2) Confidence 0.38 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14973242 Disease Relevance 1.28 Pain Relevance 0.63
Methylprednisolone pretreatment did not influence pancreatic NF-kappaB DNA binding, but decreased proinflammatory cytokine synthesis in this acute pancreatitis model.
Neg (not) Negative_regulation (influence) of NF-kappaB Binding (binding) of associated with pancreatitis and cytokine
3) Confidence 0.29 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.91 Pain Relevance 0.13
A previous study by our laboratory demonstrated that age-associated hyperglycemia and decreases in muscle glucose transporter-4 (Glut4) can be reversed by acetaminophen intervention [23], while other work using cultured cell has shown that acetaminophen can directly inhibit NO production and iNOS expression through its ability to diminish NF-kappaB binding to the iNOS gene promoter [28].
Negative_regulation (inhibit) of NF-kappaB Binding (diminish) of in muscle associated with hyperglycemia and paracetamol
4) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.32 Pain Relevance 0.34
It was postulated that the observed down-regulation of matrix metalloproteinase-9 was due to inhibition of granulocytemacrophage colonystimulating factor (GM-CSF) production which resulted in decreased binding activity of NF-kB and AP-1 transcription factors.
Negative_regulation (decreased) of NF-kB Binding (binding) of associated with metalloproteinase
5) Confidence 0.03 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 0.86 Pain Relevance 0.09
Bee venom specifically suppressed the phosphorylation of p38/JNK and at the same time, suppressed the protein expression, DNA binding and promoter activity of NF-kappaB.
Negative_regulation (suppressed) of NF-kappaB Binding (binding) of
6) Confidence 0.03 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 19969058 Disease Relevance 0.23 Pain Relevance 0
A modified EMSA was complementary and demonstrated marked inhibition of NFkappaB nuclear binding.
Negative_regulation (inhibition) of NFkappaB Binding (binding) of
7) Confidence 0.00 Published 2010 Journal Immunobiology Section Body Doc Link 19559500 Disease Relevance 0.05 Pain Relevance 0

General Comments

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