INT109061

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.80
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PRKD1) small molecule metabolic process (PRKD1) Golgi apparatus (PRKD1)
cytoplasm (PRKD1) cytosol (PRKD1) cell proliferation (PRKD1)
Anatomy Link Frequency
stroma 2
external 1
papillae 1
stem 1
PRKD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 53 100.00 Very High Very High Very High
ASIC 50 100.00 Very High Very High Very High
Kappa opioid receptor 1 100.00 Very High Very High Very High
sodium channel 46 99.80 Very High Very High Very High
Chronic pancreatitis 6 94.72 High High
opioid receptor 2 90.48 High High
Dynorphin 2 86.56 High High
Central nervous system 2 63.68 Quite High
Mechanotransduction 1 53.32 Quite High
antagonist 3 40.24 Quite Low
Disease Link Frequency Relevance Heat
Polycystic Kidney Disease 18 100.00 Very High Very High Very High
Ductal Carcinoma 2 99.36 Very High Very High Very High
Carcinoma 4 95.76 Very High Very High Very High
Pancreatitis 6 94.72 High High
Pancreatic Cancer 2 75.00 Quite High
Malignant Neoplastic Disease 2 66.64 Quite High
Ageusia 32 50.00 Quite Low
Loss Of Sense Of Smell 14 47.68 Quite Low
Disease 10 6.52 Low Low
Autosomal Dominant Polycystic Kidney 3 6.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we found that GTR1 embryonic stem (ES) cells expressed cell surface kappa opioid receptors, as well as protein kinase C (PKC)-alpha, -beta1, -beta2, -delta, -epsilon, and -zeta.
Gene_expression (expressed) of -delta in stem associated with kinase c and kappa opioid receptor
1) Confidence 0.58 Published 2003 Journal Circ. Res. Section Abstract Doc Link 12623877 Disease Relevance 0 Pain Relevance 0.48
In this study, we used RT-PCR to search for evidence of expression of the ASIC, PKD and ENaC families in the anterior fungiform (taste) papillae, in both the sour-ageusics and in three normal subjects.
Gene_expression (expression) of PKD in papillae associated with polycystic kidney disease, sodium channel and asic
2) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0.26 Pain Relevance 0.22
Major differences were found in the level of expression of the ASIC and PKD channels between the two groups, yet both groups expressed comparable levels of ?
Gene_expression (expression) of PKD associated with polycystic kidney disease and asic
3) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0.28 Pain Relevance 0.27
Experimental work suggests that PKD repeats and REJ domains might have the same function in allowing the force mediated, reversible unfolding of these domains, permitting extension and retraction of the external portions of these enormous proteins as they link to the surfaces of other cells [35].
Gene_expression (repeats) of PKD in external
4) Confidence 0.19 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0 Pain Relevance 0.03
The stroma adjacent to ductal carcinomas was characterized by prominent expression of PKC-mu and a gain in PKC-delta (P < .0001) and PKC-zeta (P > .005).
Gene_expression (expression) of PKC-mu in stroma associated with ductal carcinoma and kinase c
5) Confidence 0.08 Published 2003 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 12645342 Disease Relevance 0.64 Pain Relevance 1.03
In the adjacent stroma was enhanced expression of PKC-delta (P < .005) and PKC-gamma (P < .001) and loss of PKC-mu (P < .05).
Gene_expression (expression) of PKC-mu in stroma associated with kinase c
6) Confidence 0.06 Published 2003 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 12645342 Disease Relevance 0.63 Pain Relevance 1.02

General Comments

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