INT109062

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.31
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NKX2-5) nucleus (NKX2-5) DNA binding (NKX2-5)
transcription factor binding (NKX2-5) cytoplasm (NKX2-5)
Anatomy Link Frequency
TEK 2
plasma 1
embryonic cells 1
NKX2-5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 2 98.40 Very High Very High Very High
Angina 35 95.24 Very High Very High Very High
depression 8 81.92 Quite High
Kappa opioid receptor 1 80.24 Quite High
Kinase C 15 77.44 Quite High
Bioavailability 9 72.32 Quite High
adenocard 3 71.56 Quite High
opioid receptor 2 63.76 Quite High
imagery 8 32.00 Quite Low
Enkephalin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 29 97.28 Very High Very High Very High
Hypertrophy 5 96.24 Very High Very High Very High
Angina 10 95.24 Very High Very High Very High
Increased Venous Pressure Under Development 128 92.80 High High
Syndrome 33 91.52 High High
Cv General 3 Under Development 23 88.88 High High
Cv Unclassified Under Development 11 86.24 High High
Depression 8 81.92 Quite High
Hyperplasia 2 81.88 Quite High
Congenital Anomalies 3 80.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The prodynorphin gene and its product, dynorphin B, have been found to promote cardiogenesis in embryonic cells by inducing the expression of GATA-4 and Nkx-2.5, two transcription factor-encoding genes essential for cardiogenesis.
Gene_expression (expression) of Nkx-2.5 in embryonic cells associated with dynorphin
1) Confidence 0.75 Published 2003 Journal Circ. Res. Section Abstract Doc Link 12623877 Disease Relevance 0 Pain Relevance 0.29
Single Sk-34 cells typically showed no expression of Myf5, Pax3, Pax7, VE-cadherin or Nkx2.5, lower % expression of MyoD, M-cadherin, Cacn-1b, TEK, cardiac actin, GATA-4, Mef2c, Hand2 and isl-1, and higher (>50%) expression of c-met, Scn-1b, ?
Gene_expression (expression) of Nkx2.5 in TEK
2) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.08 Pain Relevance 0
Single Sk-34 cells typically showed no expression of Myf5, Pax3, Pax7, VE-cadherin or Nkx2.5, lower % expression of MyoD, M-cadherin, Cacn-1b, TEK, cardiac actin, GATA-4, Mef2c, Hand2 and isl-1, and higher (>50%) expression of c-met, Scn-1b, ?
Neg (no) Gene_expression (expression) of Nkx2.5 in TEK
3) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.08 Pain Relevance 0
Some physicians regard this as sufficient to diagnose CSX, the so-called broad diagnosis of CSX [65, 66].
Gene_expression (diagnosis) of CSX
4) Confidence 0.59 Published 2010 Journal Clin Res Cardiol Section Body Doc Link PMC2911526 Disease Relevance 0.59 Pain Relevance 0.23
Hence, there is a significantly higher proportion of woman compared to males in the group of patients with CSX.Fig. 1Plot of proportion of women of individual studies, including 95% confidence intervals

CSX incidence

Gene_expression (1Plot) of CSX
5) Confidence 0.59 Published 2010 Journal Clin Res Cardiol Section Body Doc Link PMC2911526 Disease Relevance 0.69 Pain Relevance 0.17
The lack of LVMI differences between the CSX group and controls confirms our statement.
Gene_expression (group) of CSX
6) Confidence 0.41 Published 2009 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2852773 Disease Relevance 0.69 Pain Relevance 0.07
We showed similar ADMA and even increased NOx plasma levels in CSX patients compared to normal controls.
Gene_expression (levels) of CSX in plasma
7) Confidence 0.41 Published 2009 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2852773 Disease Relevance 0.72 Pain Relevance 0.07
Among biochemical serum markers, only total NO serum concentrations were significantly higher in the CSX group compared to the control group (48.2 ±18.2 versus 32.1 ± 1.4 ?
Gene_expression (group) of CSX
8) Confidence 0.41 Published 2009 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2852773 Disease Relevance 0.45 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox