INT109069

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Context Info
Confidence 0.64
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.52
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Gata4) DNA binding (Gata4) transcription factor binding (Gata4)
cell-cell signaling (Gata4)
Anatomy Link Frequency
cardiomyocytes 1
cardiogenic 1
Gata4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 2 99.14 Very High Very High Very High
Kappa opioid receptor 2 98.98 Very High Very High Very High
Dynorphin 9 97.98 Very High Very High Very High
Opioid 1 81.12 Quite High
opioid receptor 4 79.92 Quite High
antagonist 2 78.64 Quite High
Kinase C 7 75.00 Quite High
Enkephalin 3 25.00 Low Low
imagery 21 5.00 Very Low Very Low Very Low
Action potential 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 29 97.20 Very High Very High Very High
Targeted Disruption 4 88.44 High High
Teratoma 10 82.12 Quite High
Death 4 78.44 Quite High
Apoptosis 4 5.00 Very Low Very Low Very Low
Severe Combined Immunodeficiency 4 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lentiviral prodynorphin transduction remarkably enhanced the transcription of GATA-4 and Nkx-2.5, two cardiac lineage-promoting genes, resulting in a dramatic increase in the number of spontaneously beating cardiomyocytes.
Transcription (transcription) of GATA-4 in cardiomyocytes
1) Confidence 0.64 Published 2007 Journal Regenerative medicine Section Body Doc Link 17465751 Disease Relevance 0 Pain Relevance 0
Lower relative expression of cardiomyogenic transcription factors, such as GATA-4, Nkx2-5, Isl-1, Mef2 and Hand2, was seen in clonal cell culture.
Transcription (transcription) of GATA-4
2) Confidence 0.13 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2262151 Disease Relevance 0.36 Pain Relevance 0
Differentiation into beating EBs was accompanied by mesodermal differentiation and dramatic activation of TWIST1, TBX5, and MEOX transcription, as well as the very clear induction of nearly all of the early cardiogenic genes, including FOXC1, ISL2, HAND1, GATA4, 5, and 6, FOXH1, and MEF2C.
Transcription (transcription) of GATA4 in cardiogenic
3) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.16 Pain Relevance 0
Direct exposure of nuclei isolated from undifferentiated ES cells to dynorphin B or U-50,488H, a synthetic kappa opioid receptor agonist, time- and dose-dependently activated the transcription of GATA-4 and Nkx-2.5, 2 cardiac lineage-promoting genes.
Transcription (transcription) of GATA-4 associated with dynorphin, agonist and kappa opioid receptor
4) Confidence 0.04 Published 2003 Journal Circ. Res. Section Abstract Doc Link 12623878 Disease Relevance 0 Pain Relevance 1.01

General Comments

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