INT109078

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Context Info
Confidence 0.22
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.08
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANGPT1) signal transduction (ANGPT1) extracellular space (ANGPT1)
extracellular region (ANGPT1) plasma membrane (ANGPT1)
Anatomy Link Frequency
blood 1
colon 1
platelet 1
body 1
ANGPT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 68 96.84 Very High Very High Very High
bradykinin 6 93.44 High High
cytokine 54 85.68 High High
Angina 4 84.92 Quite High
Inflammation 38 81.44 Quite High
headache 1 79.68 Quite High
backache 1 75.92 Quite High
metalloproteinase 17 65.60 Quite High
fibrosis 3 61.80 Quite High
ischemia 7 54.60 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 65 97.76 Very High Very High Very High
Rheumatoid Arthritis 68 96.84 Very High Very High Very High
Synovitis 17 96.72 Very High Very High Very High
Hypoxia 58 95.40 Very High Very High Very High
Disorders Of Creatine Metabolism 1 88.20 High High
Cv General 3 Under Development 4 84.92 Quite High
Hepatotoxicity 1 81.96 Quite High
INFLAMMATION 48 81.44 Quite High
Diarrhoea 6 80.48 Quite High
Headache 1 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intramyocardial transplantation of EPC after AMI induces significant and sustained increase in angiogenic, antiapoptotic, and chemoattractant factors, that are upregulated in both transplanted and host cells (i.e., vascular endothelial growth factor-A [VEGF-A], fibroblast growth factor-2 [FGF-2], angiopoietin-1 [Ang-1], angiopoietin-2 [Ang-2], placenta growth factor [PIGF], hepatocyte growth factor [HGF], insulin-like growth factor-1 [IGF-1], platelet-derived growth factor-B [PDGF-B], and stromal cell-derived factor-1 [SDF-1]) [35].
Positive_regulation (upregulated) of angiopoietin-1 in platelet associated with myocardial infarction
1) Confidence 0.22 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2975079 Disease Relevance 0.62 Pain Relevance 0.33
Both drugs caused a decrease in angiotensin (Ang) II level, an increase in Ang I level, and reduction in Ang II/Ang I ratio in arterial and coronary sinus blood.
Positive_regulation (increase) of Ang I in blood
2) Confidence 0.13 Published 2003 Journal Hypertension Section Abstract Doc Link 12623947 Disease Relevance 0.08 Pain Relevance 0.31
Similarly, the angiopoietins Ang1 and Ang2, and their cellular receptor Tie2, which are all widely expressed in RA synovitis, are regulated by both hypoxia and TNF-?
Positive_regulation (angiopoietins) of Ang1 associated with hypoxia, synovitis and rheumatoid arthritis
3) Confidence 0.10 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 1.15 Pain Relevance 0.31
This assumption is further supported by the high levels of angiogenic growth factor (Vascular Endothelial Growth Factor C, Placental Growth Factor, Angiopoietin-1 and 2, Transforming Growth Factor -?)
Positive_regulation (levels) of Angiopoietin-1
4) Confidence 0.06 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.10
When this increase occurs during treatment with ACEIs and ARBs, the result is increased levels of PRA but during treatment with aliskiren, the effect of increased renin levels is blocked, so the levels of Ang I and Ang II, as well as PRA, are all reduced.52 The clinical trials do not report any major adverse effects of aliskiren compared with ARBs or ACEs being generally well tolerated by all patients.
Positive_regulation (increased) of Ang I
5) Confidence 0.04 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 1.11 Pain Relevance 0.16
The ratio of plasma Ang 1 to Ang 2 levels is thought to be a measure of the body’s tendency toward VEGF-mediated angiogenesis.
Positive_regulation (ratio) of Ang 1 in body
6) Confidence 0.04 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2814196 Disease Relevance 0.06 Pain Relevance 0
A study investigating the benign pathology of open and closed colon and rectal resection patients demonstrated that both surgical methods are associated with a decrease in Ang 1 and an increase in Ang 2 levels on PODs 1 and 3 such that a significantly greater Ang 1/Ang 2 ratio was noted at both time points.
Positive_regulation (increase) of Ang 1 in colon
7) Confidence 0.04 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2814196 Disease Relevance 0.06 Pain Relevance 0

General Comments

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