INT109079

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 2.20
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANG) DNA binding (ANG) extracellular space (ANG)
extracellular region (ANG) cell death (ANG) nucleolus (ANG)
Anatomy Link Frequency
blood 3
plasma 2
ANG (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 56 95.12 Very High Very High Very High
Angina 4 86.64 High High
agonist 4 72.40 Quite High
Inflammation 35 59.76 Quite High
antagonist 11 33.32 Quite Low
cytokine 5 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pre-eclampsia 132 99.12 Very High Very High Very High
Syndrome 16 94.16 High High
Coronary Artery Disease 11 87.16 High High
Cv General 3 Under Development 4 86.64 High High
Atherosclerosis 35 82.00 Quite High
Hypertension 21 80.48 Quite High
Atherosclerotic Plaque 6 66.52 Quite High
INFLAMMATION 38 59.76 Quite High
Disorder Of Lipid Metabolism 11 30.72 Quite Low
Increased Venous Pressure Under Development 52 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both drugs caused a decrease in angiotensin (Ang) II level, an increase in Ang I level, and reduction in Ang II/Ang I ratio in arterial and coronary sinus blood.
Negative_regulation (decrease) of Ang in blood
1) Confidence 0.57 Published 2003 Journal Hypertension Section Abstract Doc Link 12623947 Disease Relevance 0.09 Pain Relevance 0.31
Both drugs caused a decrease in angiotensin (Ang) II level, an increase in Ang I level, and reduction in Ang II/Ang I ratio in arterial and coronary sinus blood.
Negative_regulation (reduction) of Ang in blood
2) Confidence 0.42 Published 2003 Journal Hypertension Section Abstract Doc Link 12623947 Disease Relevance 0.09 Pain Relevance 0.34
Although plasma Ang II concentrations are reduced, women who will develop preeclampsia show a heightened pressor response to Ang II infusion weeks in advance to the clinical manifestation of the syndrome, while this response is blunted in normotensive pregnant women[9].
Negative_regulation (reduced) of Ang in plasma associated with syndrome and pre-eclampsia
3) Confidence 0.36 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.59 Pain Relevance 0.04
In preeclampsia PRA, plasma renin concentration and plasma Ang II are reduced compared to normal pregnancy[52].
Negative_regulation (reduced) of Ang in plasma associated with pre-eclampsia
4) Confidence 0.36 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.58 Pain Relevance 0.03
At gestational day 7 Ang-(1–7) levels are downregulated in the implantation zone.
Negative_regulation (downregulated) of Ang
5) Confidence 0.32 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.08 Pain Relevance 0
The differences in tissue versus circulating concentrations of the various components of the RAS are highlighted by the fact that Ang-(1–7) is decreased in the blood of preeclamptic women[57].
Negative_regulation (decreased) of Ang in blood
6) Confidence 0.23 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.15 Pain Relevance 0.03
Furthermore, ANG II-induced sPLA2 activity and LDL-peroxidation were prevented by the sPLA2-IIA activity inhibitor LY311727 (Luchtefeld et al 2006).
Negative_regulation (prevented) of ANG
7) Confidence 0.08 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.63 Pain Relevance 0.06

General Comments

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