INT109081

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.72
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
nucleus 2
myocytes 1
heart 1
Nppa (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 37 95.72 Very High Very High Very High
Inflammatory response 1 93.40 High High
anesthesia 7 83.96 Quite High
Pain 2 81.72 Quite High
agonist 12 79.84 Quite High
midbrain 1 70.88 Quite High
Clonidine 2 58.24 Quite High
Inflammation 18 50.00 Quite Low
Multiple sclerosis 9 5.00 Very Low Very Low Very Low
Eae 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Natriuresis 32 100.00 Very High Very High Very High
Body Weight 31 99.20 Very High Very High Very High
Sprains And Strains 96 98.88 Very High Very High Very High
Pneumonia 47 98.38 Very High Very High Very High
Demyelinating Disease 55 95.72 Very High Very High Very High
Hypertension 13 95.28 Very High Very High Very High
INFLAMMATION 20 93.04 High High
Paralysis 2 86.96 High High
Death 13 85.88 High High
Tremor 2 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
10 litters each strain) were used for baseline measurements of the ultrasonic vocalizations from pnd 2 to 12.
Localization (vocalizations) of pnd associated with sprains and strains
1) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516927 Disease Relevance 0.37 Pain Relevance 0.17
-adrenergic responses by ANP
Localization (responses) of ANP
2) Confidence 0.56 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.19 Pain Relevance 0.04
After obtaining basal recordings for 10 min, myocytes were exposed to Ang II (10 nM) or isoproterenol (ISO, 100 nM; both Sigma, Taufkirchen, Germany) in the presence or absence of ANP (mouse ANP, 100 nM; Bachem, Heidelberg, Germany) (superfusion of cardiomyocytes with ANP or vehicle during 10 min; then superfusion with Ang II or ISO in the presence of ANP during additional 10 min).


Localization (presence) of ANP in myocytes
3) Confidence 0.56 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
After 2 days of transfection, the cells were treated with ANP (10 nM) or vehicle for the indicated time.
Localization (treated) of ANP
4) Confidence 0.56 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
Furthermore, local release of atrial natriuretic peptide inhibits norepinephrine release in this nucleus, blocking local activation of alpha2-adrenergic receptors, and thereby contributes to NaCl-sensitive hypertension in spontaneously hypertensive rats.
Localization (release) of atrial natriuretic peptide in nucleus associated with natriuresis and hypertension
5) Confidence 0.33 Published 2003 Journal Hypertension Section Abstract Doc Link 12623961 Disease Relevance 0.44 Pain Relevance 0.10
Furthermore, local release of atrial natriuretic peptide inhibits norepinephrine release in this nucleus, blocking local activation of alpha2-adrenergic receptors, and thereby contributes to NaCl-sensitive hypertension in spontaneously hypertensive rats.
Localization (release) of atrial natriuretic peptide in nucleus associated with natriuresis and hypertension
6) Confidence 0.33 Published 2003 Journal Hypertension Section Abstract Doc Link 12623961 Disease Relevance 0.44 Pain Relevance 0.09
The heart rate of females showed a small decrease from PND20 to PND22, while the heart rate of males continued to increase, with two sexes reaching values of 791 ± 31 bpm and 828 ± 22 bpm, respectively (Figure 2A).
Localization (decrease) of PND20 in heart
7) Confidence 0.31 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2936334 Disease Relevance 0.12 Pain Relevance 0
Two out of five twi/twi treated from PND 30 revealed strikingly milder clinical symptoms (Fig. 3A).
Localization (treated) of PND
8) Confidence 0.25 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 0.82 Pain Relevance 0.22
Discriminatory power of biomarkers for predicting serious complications in CAP patients as assessed by the area under the ROC curve (AUC) ranged from 0.66 for proANP to 0.72 for proADM and proET1 (Table 1).
Localization (0.72) of proANP associated with pneumonia
9) Confidence 0.19 Published 2010 Journal Crit Care Section Body Doc Link PMC2911752 Disease Relevance 0.34 Pain Relevance 0

General Comments

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