INT109095

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Context Info
Confidence 0.40
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.60
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd4) cytoplasm (Drd4) signal transducer activity (Drd4)
Anatomy Link Frequency
cerebral cortex 1
nucleus 1
Drd4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 269 100.00 Very High Very High Very High
Serotonin 38 100.00 Very High Very High Very High
monoamine 10 100.00 Very High Very High Very High
dopamine receptor 34 99.80 Very High Very High Very High
addiction 8 99.48 Very High Very High Very High
cerebral cortex 6 99.16 Very High Very High Very High
Hyperalgesia 1 96.80 Very High Very High Very High
opiate 1 96.56 Very High Very High Very High
Opioid 10 95.96 Very High Very High Very High
Neuropeptide 1 95.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Opiate Addiction 6 99.76 Very High Very High Very High
Migraine With Aura 4 99.44 Very High Very High Very High
Migraine Without Aura 5 99.20 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 166 98.88 Very High Very High Very High
Hyperalgesia 1 96.80 Very High Very High Very High
Pain 9 94.92 High High
Alcohol Addiction 32 91.92 High High
Schizophrenia 2 90.52 High High
Drug Dependence 4 87.76 High High
Headache 6 87.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The dopamine receptor D4 gene (DRD4) is associated with heroin dependence; one of its polymorphisms is a C/T variation 521 bp upstream to the gene (-521C/T).
DRD4 Binding (associated) of associated with addiction, dopamine receptor and opiate addiction
1) Confidence 0.40 Published 2008 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18991844 Disease Relevance 0.82 Pain Relevance 0.90
Our data indicate that MO, but not MA, shows significant genetic association with DRD4.
DRD4 Binding (association) of associated with migraine with aura and migraine without aura
2) Confidence 0.29 Published 2003 Journal Neurol. Sci. Section Abstract Doc Link 12624717 Disease Relevance 1.08 Pain Relevance 0.72
At 96 h after the administration of picrotoxin into the basolateral nucleus, we have observed an increase in the expression of genes associated with 18 different monoamine (ie adrenergic alpha 1, alpha 2 and beta 2, serotonergic 5HT5b and 5HT6, dopamine D4 and muscarinic m1, m2 and m3) and peptide (CCK A and B, angiotensin 1A, mu and kappa opiate, FSH, TSH, LH, GNRH, and neuropeptide Y) G-protein coupled receptors (GPCRs).
dopamine D4 Binding (associated) of in nucleus associated with dopamine, neuropeptide, opiate and monoamine
3) Confidence 0.18 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 15170462 Disease Relevance 0.09 Pain Relevance 0.38
Hyperactivity was accompanied by decreased dopamine [162], increased DRD4 [164], and increased serotonin transporter binding in striatum but not cerebral cortex [165].
DRD4 Binding (binding) of in cerebral cortex associated with dopamine, attention deficit hyperactivity disorder, cerebral cortex and serotonin
4) Confidence 0.15 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.87 Pain Relevance 0.41
It was also shown a significant association between the genotype at DRD4 and the children of alcoholic patients [16].
DRD4 Binding (association) of
5) Confidence 0.13 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898022 Disease Relevance 0.68 Pain Relevance 0.27
Also, a significant interaction between the 5-HTTLPR-l allele and the dopamine D4 receptor-7 repeat polymorphism in relation to novelty seeking has been reported [11], and a significant interaction between the 5-HTTLPR-s allele and the DRD4-7 repeat for harm avoidance [12].
D4 receptor-7 Binding (interaction) of associated with dopamine
6) Confidence 0.07 Published 2010 Journal BMC Genet Section Body Doc Link PMC2874760 Disease Relevance 0.06 Pain Relevance 0.32
Scattered cell bodies in the rat GP showed immunoreactivity for D2-, D3-, and D4-receptor (Khan et al., 1998).
D4-receptor Binding (immunoreactivity) of
7) Confidence 0.03 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.19

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