INT109104

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.44
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
internal 2
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 2 99.86 Very High Very High Very High
Inflammatory mediators 18 99.36 Very High Very High Very High
Chronic pancreatitis 4 94.40 High High
Opioid 3 88.68 High High
Endogenous opioid 1 85.72 High High
chemokine 1 80.52 Quite High
cytokine 12 79.92 Quite High
addiction 4 79.24 Quite High
Inflammatory marker 1 76.00 Quite High
metalloproteinase 2 74.08 Quite High
Disease Link Frequency Relevance Heat
Obesity 136 100.00 Very High Very High Very High
Insulin Resistance 7 100.00 Very High Very High Very High
Diabetes Mellitus 105 99.40 Very High Very High Very High
INFLAMMATION 102 99.36 Very High Very High Very High
Hyperglycemia 7 97.68 Very High Very High Very High
Pulmonary Disease 95 97.36 Very High Very High Very High
Overweight 2 96.76 Very High Very High Very High
Metabolic Syndrome 13 94.44 High High
Pancreatitis 5 93.28 High High
Appetite Loss 9 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sweets release opiates which stimulates the appetite for sucrose--insulin can depress it].
Positive_regulation (stimulates) of Protein_catabolism (sucrose--) of insulin associated with opiate
1) Confidence 0.50 Published 2005 Journal Lakartidningen Section Title Doc Link 15962882 Disease Relevance 0.24 Pain Relevance 0.61
of internal insulin are largely degraded, it cannot appropriately facilitate
Positive_regulation (facilitate) of Protein_catabolism (degraded) of insulin in internal
2) Confidence 0.50 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 1.30 Pain Relevance 0
Consequently, diabetes may be worsened by enzymatic degradation of insulin by gelatinase B and by the consequent enhancement of the autoimmune process.
Positive_regulation (enhancement) of Protein_catabolism (degradation) of insulin associated with diabetes mellitus
3) Confidence 0.35 Published 2003 Journal FASEB J. Section Abstract Doc Link 12626433 Disease Relevance 0.49 Pain Relevance 0.46
The study by Bolton et al. [59] suggests that insulin resistance is aggravated by both, high BMI and increases in circulatory inflammatory mediators such as IL-6 in these patients.
Positive_regulation (increases) of Protein_catabolism (aggravated) of insulin associated with inflammatory mediators, obesity and insulin resistance
4) Confidence 0.17 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 2.41 Pain Relevance 0.17

General Comments

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