INT109105

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Context Info
Confidence 0.46
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.98
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP2) extracellular space (MMP2) extracellular region (MMP2)
proteinaceous extracellular matrix (MMP2) plasma membrane (MMP2) nucleus (MMP2)
Anatomy Link Frequency
myocytes 2
ECM 2
MMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 6 100.00 Very High Very High Very High
ischemia 1 97.12 Very High Very High Very High
cva 15 95.60 Very High Very High Very High
Chronic pancreatitis 4 94.40 High High
Paracetamol 9 90.24 High High
cINOD 13 81.84 Quite High
chemokine 3 80.52 Quite High
cytokine 5 80.40 Quite High
Inflammation 32 80.04 Quite High
dexamethasone 28 77.80 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 2 99.40 Very High Very High Very High
Cv Unclassified Under Development 1 97.12 Very High Very High Very High
Reperfusion Injury 1 96.76 Very High Very High Very High
Apoptosis 3 96.52 Very High Very High Very High
Cv General 4 Under Development 3 95.60 Very High Very High Very High
Death 13 95.56 Very High Very High Very High
Pancreatitis 5 93.28 High High
INFLAMMATION 41 80.04 Quite High
Alzheimer's Dementia 18 71.96 Quite High
Cerebral Amyloid Angiopathy 32 66.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consequently, diabetes may be worsened by enzymatic degradation of insulin by gelatinase B and by the consequent enhancement of the autoimmune process.
Positive_regulation (enhancement) of Protein_catabolism (degradation) of gelatinase B associated with diabetes mellitus
1) Confidence 0.46 Published 2003 Journal FASEB J. Section Abstract Doc Link 12626433 Disease Relevance 0.49 Pain Relevance 0.46
In addition to a direct loss of vessel wall integrity, MMP-2 mediated degradation of ECM components may lead to loss of specific ECM-integrin interactions resulting in apoptotic vascular cell death [40].
Positive_regulation (mediated) of Protein_catabolism (degradation) of MMP-2 in ECM associated with apoptosis and death
2) Confidence 0.30 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1557842 Disease Relevance 1.30 Pain Relevance 0.54
The peroxynitrite-mediated activation of matrix metalloproteinase-2 (MMP-2) and subsequent cleavage of troponin I (TnI) in ventricular myocytes is a detrimental effect of ischemia/reperfusion injury.
Positive_regulation (activation) of Protein_catabolism (cleavage) of metalloproteinase-2 in myocytes associated with reperfusion injury, ischemia and metalloproteinase
3) Confidence 0.05 Published 2006 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16530785 Disease Relevance 0.19 Pain Relevance 0.37

General Comments

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