INT109108

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Context Info
Confidence 0.61
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.78
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc3r) plasma membrane (Mc3r) signal transducer activity (Mc3r)
Anatomy Link Frequency
hypothalamus 1
peritoneal macrophages 1
Mc3r (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 23 93.12 High High
agonist 23 92.64 High High
Central nervous system 30 87.28 High High
Inflammation 3 83.72 Quite High
Cholecystokinin 16 80.80 Quite High
Action potential 8 80.40 Quite High
gABA 16 79.84 Quite High
melanocortin 1 receptor 1 75.00 Quite High
chemokine 1 68.64 Quite High
cytokine 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Sprains And Strains 11 96.68 Very High Very High Very High
INFLAMMATION 3 83.72 Quite High
Obesity 114 76.36 Quite High
Anorexia 28 64.88 Quite High
Weight Gain 8 50.80 Quite High
Generalized Anxiety Disorder 4 22.24 Low Low
Thinness 4 18.44 Low Low
Appetite Loss 20 5.00 Very Low Very Low Very Low
Stress 8 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite this, mc3r and mc4r mRNA are abundant (Table 3; [90,118]).
Transcription (abundant) of mc3r
1) Confidence 0.61 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.13 Pain Relevance 0.12
A large proportion of NPY neurones in the rat hypothalamus express mc3r mRNA while a much lower number of NPY neurones express mc4r mRNA, suggesting that POMC neurones may directly modulate the activity of the hypothalamic NPY system too, mainly through activation of MC3R [61].
Transcription (express) of mc3r in hypothalamus
2) Confidence 0.45 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.40 Pain Relevance 0.29
RT-PCR and ultrastructural analyses showed the presence of MC3-R mRNA and protein in peritoneal macrophages (M phi) collected from recessive yellow (e/e) mice and wild-type mice.
Transcription (presence) of MC3-R in peritoneal macrophages
3) Confidence 0.13 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12626592 Disease Relevance 0.26 Pain Relevance 0.42

General Comments

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