INT109133

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 52
Total Number 53
Disease Relevance 53.11
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VCAN) extracellular region (VCAN) cell adhesion (VCAN)
proteinaceous extracellular matrix (VCAN)
Anatomy Link Frequency
fibroblasts 5
long bones 2
macrophage 1
tendons 1
temporomandibular joint 1
VCAN (Homo sapiens)
Pain Link Frequency Relevance Heat
Snapping jaw 2 99.60 Very High Very High Very High
Myofascial pain syndrome 1 97.36 Very High Very High Very High
cytokine 39 96.88 Very High Very High Very High
Inflammation 37 84.72 Quite High
imagery 36 83.96 Quite High
Sciatic nerve 34 78.40 Quite High
fibrosis 15 76.64 Quite High
metalloproteinase 36 69.12 Quite High
Pain 2 10.00 Low Low
Spinal cord 105 6.64 Low Low
Disease Link Frequency Relevance Heat
Cancer 2746 99.84 Very High Very High Very High
Malignant Neoplastic Disease 181 99.84 Very High Very High Very High
Breast Cancer 1196 99.72 Very High Very High Very High
Ductal Carcinoma 68 99.72 Very High Very High Very High
Colon Cancer 3 99.72 Very High Very High Very High
Weight Loss 69 99.68 Very High Very High Very High
Temporomandibular Joint Syndrome 2 99.60 Very High Very High Very High
Adenocarcinoma 34 99.56 Very High Very High Very High
Metastasis 923 99.30 Very High Very High Very High
Apoptosis 252 99.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, biochemical protein analysis supplemented our stereological quantification and demonstrated no changes in protein expression levels of Fibronectin, NG2, Versican, GFAP, and PE-CAM1 at 2 weeks post-transplant.
Gene_expression (expression) of Versican
1) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690693 Disease Relevance 0.42 Pain Relevance 0
Further, biochemical analyses supplement stereological data and demonstrate no changes in Fibronectin, Versican, GFAP, NG2, and PE-CAM1 protein expression at 2 weeks post-transplant.
Gene_expression (expression) of Versican
2) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690693 Disease Relevance 0.15 Pain Relevance 0
RESULTS: Painful and ruptured tendons showed a significant decrease (median 2-fold) in the expression of versican mRNA, in contrast to an increased expression (median 8-fold) of type I collagen alpha1 mRNA in painful tendons.
Gene_expression (expression) of versican in tendons
3) Confidence 0.65 Published 2004 Journal Rheumatology (Oxford) Section Body Doc Link 15138331 Disease Relevance 0.08 Pain Relevance 0
There was a marked decrease of versican V0 expression at 10?
Gene_expression (expression) of versican
4) Confidence 0.65 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.73 Pain Relevance 0
Additionally, biochemical protein analysis supplemented our stereological quantification and demonstrated no changes in protein expression levels of Fibronectin, NG2, Versican, GFAP, and PE-CAM1 at 2 weeks post-transplant.
Gene_expression (levels) of Versican
5) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690693 Disease Relevance 0.42 Pain Relevance 0
The purpose of this study was to investigate the expression of PG mRNA in human temporomandibular joint (TMJ ) disks from patients with temporomandibular disorders (TMD).
Spec (investigate) Gene_expression (expression) of PG mRNA in temporomandibular joint associated with snapping jaw and myofascial pain syndrome
6) Confidence 0.44 Published 2002 Journal J. Med. Dent. Sci. Section Abstract Doc Link 12627818 Disease Relevance 0.27 Pain Relevance 0.27
Transcript levels of COL4A2, S100A10, CSPG2 and hMT-Ie were up regulated by TGF-?
Gene_expression (levels) of CSPG2
7) Confidence 0.41 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 0.69 Pain Relevance 0
Data obtained in our study also indicate that adhesion fibroblasts may resist apoptosis due to anti apoptotic effects mediated by increased hMet1-e and CSPG2 levels and down regulation of IGFBP3.
Gene_expression (levels) of CSPG2 in fibroblasts associated with apoptosis and adhesions
8) Confidence 0.41 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 1.26 Pain Relevance 0.05
VCAN expression is elevated in our invasive Motif 1 NZM cells, which is in agreement with a recent report that VCAN is up-regulated in invasive human melanoma cells via a TCF4/AP1-mediated mechanism [37].
Gene_expression (expression) of VCAN associated with melanoma
9) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 1.58 Pain Relevance 0.09
It is apparent now that higher proliferative and reduced apoptotic nature of adhesion fibroblasts in human as reported earlier [5] could also derive from altered expression of hMet1-e, CSPG2, S100A10, CSPG2, IGFBP3, and the Bfl-1 that inhibits p53-induced apoptosis and is induced by cytokines TNF-?
Gene_expression (expression) of CSPG2 in fibroblasts associated with apoptosis, adhesions and cytokine
10) Confidence 0.36 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 1.71 Pain Relevance 0.12
It is apparent now that higher proliferative and reduced apoptotic nature of adhesion fibroblasts in human as reported earlier [5] could also derive from altered expression of hMet1-e, CSPG2, S100A10, CSPG2, IGFBP3, and the Bfl-1 that inhibits p53-induced apoptosis and is induced by cytokines TNF-?
Gene_expression (expression) of CSPG2 in fibroblasts associated with apoptosis, adhesions and cytokine
11) Confidence 0.36 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 1.73 Pain Relevance 0.12
Interestingly, however, VCAN was expressed significantly higher in AF and NP cells when compared with AC cells.
Gene_expression (expressed) of VCAN
12) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
Global transcript profiling identified a signature featuring decreased expression of developmental and lineage specification genes including MITF, EDNRB, DCT, and TYR, and increased expression of genes involved in interaction with the extracellular environment, such as PLAUR, VCAN, and HIF1a.
Gene_expression (expression) of VCAN
13) Confidence 0.30 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2794539 Disease Relevance 0.75 Pain Relevance 0
Global transcript profiling identified a signature featuring decreased expression of developmental and lineage specification genes including MITF, EDNRB, DCT, and TYR, and increased expression of genes involved in interaction with the extracellular environment, such as PLAUR, VCAN, and HIF1a.
Gene_expression (expression) of VCAN
14) Confidence 0.30 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2794539 Disease Relevance 0.77 Pain Relevance 0
This 87-fold difference in VCAN expression between NP and AC compared with the small fold differences in the other typical marker genes highlights the potential of VCAN as a good marker for differentiating these cell types and corroborates previous literature comparing VCAN content of AC and IVD tissues [39].
Gene_expression (expression) of VCAN
15) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
The results demonstrated that pre-existing marker genes generally showed the expected pattern of expression, that is high expression of ACAN in NP and AC, high expression of type I collagen in AF compared with NP and AC, and high expression of versican (VCAN) in both NP and AF compared with AC.
Gene_expression (expression) of VCAN
16) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
Eleven genes (SNAP25, KRT8, KRT18, KRT19, CDH2, IBSP, VCAN, TNMD, BASP1, FOXF1 & FBLN1) were also differentially expressed in normal human NP cells, although to a lesser degree.
Gene_expression (expressed) of VCAN
17) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
The expression of VCAN was significantly lower in AC cells when compared with both AF and NP cells (P < 0.0001) demonstrating its potential as a gene marker that can distinguish between AC and NP cells.
Gene_expression (expression) of VCAN
18) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0.11 Pain Relevance 0
Extracellular matrices that express high amounts of versican may function as modulators of cell proliferation and migration [32].
Gene_expression (express) of versican
19) Confidence 0.10 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.65 Pain Relevance 0
As a recognized modulator of cell adhesion and motility for mesenchymal cells, increased versican expression in malignant derivatives appears to contribute towards a more aggressive phenotype [20,21].
Gene_expression (expression) of versican in mesenchymal cells associated with malignant neoplastic disease and adhesions
20) Confidence 0.10 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.61 Pain Relevance 0.03

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