INT10915

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2010
Negated 6
Speculated 8
Reported most in Abstract
Documents 164
Total Number 174
Disease Relevance 92.42
Pain Relevance 29.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGAM) plasma membrane (ITGAM)
Anatomy Link Frequency
neutrophils 51
monocytes 22
granulocyte 12
leukocyte 10
macrophages 8
ITGAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1953 100.00 Very High Very High Very High
cytokine 593 100.00 Very High Very High Very High
Morphine 5 99.92 Very High Very High Very High
Angina 75 99.88 Very High Very High Very High
Enkephalin 62 99.78 Very High Very High Very High
lidocaine 45 99.70 Very High Very High Very High
Opioid 99 99.60 Very High Very High Very High
Nicotine 1155 99.58 Very High Very High Very High
narcan 12 99.26 Very High Very High Very High
local anesthetic 61 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2541 100.00 Very High Very High Very High
Adhesions 1947 100.00 Very High Very High Very High
Cancer 317 100.00 Very High Very High Very High
Necrosis 75 100.00 Very High Very High Very High
Hypersensitivity 58 100.00 Very High Very High Very High
Nicotine Addiction 3321 99.92 Very High Very High Very High
Cv General 3 Under Development 92 99.88 Very High Very High Very High
Injury 509 99.72 Very High Very High Very High
Airway Obstruction 49 99.52 Very High Very High Very High
Apoptosis 482 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After viable Staphylococcus aureus was added in a 5 to 1 ratio following leukocyte count, phagocytosis was stopped at different times, and staining with monoclonal antibodies was performed for subsequent flow cytometric analysis of phagocytosis activity, oxidative burst, and CD11b expression.
Gene_expression (expression) of CD11b in leukocyte
1) Confidence 0.78 Published 2003 Journal Anesthesiology Section Body Doc Link 12657844 Disease Relevance 0.07 Pain Relevance 0
RESULTS: Granulocyte phagocytosis activity, CD11b expression, and generation of reactive oxygen species were significantly reduced by lidocaine (P < 0.0002) and bupivacaine (P < 0.005) in the highest concentration (1,846 microm and 770 microm, respectively).
Gene_expression (expression) of CD11b in Granulocyte
2) Confidence 0.78 Published 2003 Journal Anesthesiology Section Body Doc Link 12657844 Disease Relevance 0.07 Pain Relevance 0
Ropivacaine inhibited CD11b expression in formyl-methionyl-leucyl-phenylalanine (fMLP)-activated neutrophils in a concentration-dependent manner, but not in a time-dependent manner.
Gene_expression (expression) of CD11b in neutrophils
3) Confidence 0.77 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.40 Pain Relevance 0.37
However, ropivacaine showed no effect on the fMLP-induced CD11b expression in the presence of butan-1-ol, a blocker of phospholipase D (PLD) pathway, which completely inhibited the fMLP-induced CD11b expression in neutrophils.
Gene_expression (expression) of CD11b in neutrophils
4) Confidence 0.77 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.37 Pain Relevance 0.24
The aim of this study was to investigate anti-inflammatory properties of ropivacaine with regard to its effects on the expression and function of CD11b in human neutrophils.
Gene_expression (expression) of CD11b in neutrophils associated with inflammation
5) Confidence 0.77 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.35 Pain Relevance 0.37
CD11b expression was examined by flow cytometry and its function was determined by measuring adhesion of neutrophils to human umbilical vein endothelial cells (HUVECs).
Spec (examined) Gene_expression (expression) of CD11b in endothelial cells associated with adhesions
6) Confidence 0.77 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.41 Pain Relevance 0.37
However, ropivacaine showed no effect on the fMLP-induced CD11b expression in the presence of butan-1-ol, a blocker of phospholipase D (PLD) pathway, which completely inhibited the fMLP-induced CD11b expression in neutrophils.
Gene_expression (expression) of CD11b in neutrophils
7) Confidence 0.77 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.36 Pain Relevance 0.18
In addition, ropivacaine more potently inhibited the fMLP-induced CD11b expression in the presence of ethylene glycol-bis(2-aminoethylether)-N,N,N ,N -tetraacetic acid (EGTA), a chelator of extracellular Ca(2+).
Gene_expression (expression) of CD11b
8) Confidence 0.77 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.43 Pain Relevance 0.34
Our results suggest that ropivacaine exerts anti-inflammatory activity, and this appears to be mediated through inhibiting the expression and function of adhesion molecule CD11b in neutrophils.
Gene_expression (expression) of CD11b in neutrophils associated with inflammation and adhesions
9) Confidence 0.77 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.40 Pain Relevance 0.15
Effects of ropivacaine on adhesion molecule CD11b expression and function in human neutrophils.
Gene_expression (expression) of CD11b in neutrophils associated with adhesions
10) Confidence 0.77 Published 2010 Journal Int. Immunopharmacol. Section Title Doc Link 20348036 Disease Relevance 0.42 Pain Relevance 0.38
We hypothesized that local anesthetics have time-dependent effects on phagocytosis of S. aureus, oxidative burst, and CD11b expression by human neutrophils.
Gene_expression (expression) of CD11b in neutrophils
11) Confidence 0.77 Published 2008 Journal Reg Anesth Pain Med Section Abstract Doc Link 18675739 Disease Relevance 0.18 Pain Relevance 0.30
Thereafter, bacteria were added, either fluorescently labeled for determination of phagocytosis, or unstained for determination of oxidative burst and CD11b expression.
Gene_expression (expression) of CD11b
12) Confidence 0.77 Published 2008 Journal Reg Anesth Pain Med Section Body Doc Link 18675739 Disease Relevance 0 Pain Relevance 0
Prolonged local anesthetic exposure reduced the fraction of ingesting neutrophils by 20% +/- 12% (mean +/- SD) and 7% +/- 7%, bacterial uptake by 19% +/- 16% and 14% +/- 12%, oxidative burst by 29% +/- 23% and 28% +/- 25%, and CD11b expression by 66% +/- 24% and 25% +/- 21% for lidocaine and bupivacaine, respectively.
Gene_expression (expression) of CD11b in neutrophils
13) Confidence 0.77 Published 2008 Journal Reg Anesth Pain Med Section Body Doc Link 18675739 Disease Relevance 0 Pain Relevance 0
Ropivacaine exerted a time-dependent effect on CD11b expression only (24% +/- 34%; P < .05).
Gene_expression (expression) of CD11b
14) Confidence 0.77 Published 2008 Journal Reg Anesth Pain Med Section Body Doc Link 18675739 Disease Relevance 0 Pain Relevance 0
Local anesthetics time-dependently inhibit staphylococcus aureus phagocytosis, oxidative burst and CD11b expression by human neutrophils.
Gene_expression (expression) of CD11b in neutrophils associated with local anesthetic
15) Confidence 0.77 Published 2008 Journal Reg Anesth Pain Med Section Title Doc Link 18675739 Disease Relevance 0.19 Pain Relevance 0.33
TNF-alpha and interleukin-8 might increase the expression of the CD11b-CD18 constitutively present on the polymorphonuclear neutrophils membrane and facilitate their rolling and diapedesis through the vascular endothelial wall [2,6].
Gene_expression (expression) of CD11b in polymorphonuclear neutrophils
16) Confidence 0.75 Published 2003 Journal BMC Musculoskelet Disord Section Body Doc Link PMC194711 Disease Relevance 1.51 Pain Relevance 0.30
We found that coronary angioplasty with stent implantation produces an increase in the cell surface expression of CD11b/CD18 in neutrophils and CD38 in monocytes, following a similar time-course with a peak after 24 h, returning to basal levels after 48 h and a second peak after 7 days.
Gene_expression (expression) of CD11b in neutrophils
17) Confidence 0.75 Published 2004 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 15080559 Disease Relevance 0.30 Pain Relevance 0.26
CD11b/CD18 membrane expression was approximately 70% higher on unstimulated SCD neutrophils than controls, which correlated with a 1-fold higher rate of adhesion to ligand.
Gene_expression (expression) of CD11b in neutrophils associated with sickle cell anemia and adhesions
18) Confidence 0.75 Published 2004 Journal Am. J. Hematol. Section Abstract Doc Link 15164377 Disease Relevance 0.97 Pain Relevance 0.10
The effect of lidocaine on neutrophil CD11b/CD18 and endothelial ICAM-1 expression and IL-1beta concentrations induced by hypoxia-reoxygenation.
Gene_expression (expression) of CD11b in neutrophil associated with hypoxia and lidocaine
19) Confidence 0.75 Published 2004 Journal Eur J Anaesthesiol Section Title Doc Link 15719860 Disease Relevance 0.10 Pain Relevance 0.20
METHODS: Isolated human neutrophil CD11b and CD18, and human umbilical vein endothelial cell (HUVEC) ICAM-1 expression and supernatant IL-1beta concentrations in response to hypoxia-reoxygenation were studied in the presence or absence of different concentrations of lidocaine (0.005, 0.05 and 0.5 mg mL(-1)).
Gene_expression (expression) of CD11b in neutrophil
20) Confidence 0.75 Published 2004 Journal Eur J Anaesthesiol Section Body Doc Link 15719860 Disease Relevance 0.29 Pain Relevance 0

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