INT109150

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2005
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 7
Disease Relevance 2.04
Pain Relevance 5.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 1
Tubgcp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 27 100.00 Very High Very High Very High
tolerance 17 100.00 Very High Very High Very High
addiction 13 100.00 Very High Very High Very High
Opioid 7 100.00 Very High Very High Very High
Antinociceptive 8 99.32 Very High Very High Very High
Morphine 35 97.64 Very High Very High Very High
withdrawal 12 95.68 Very High Very High Very High
Sciatic nerve 4 85.60 High High
tail-flick 2 81.52 Quite High
Pain threshold 2 75.84 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 7 100.00 Very High Very High Very High
Injury 6 99.80 Very High Very High Very High
Peripheral Neuropathy 4 98.52 Very High Very High Very High
Stroke 4 98.20 Very High Very High Very High
Morphine Dependence 5 97.86 Very High Very High Very High
Middle Cerebral Artery Infarction 2 97.44 Very High Very High Very High
Cognitive Disorder 2 76.28 Quite High
Pain 2 75.84 Quite High
Brain Hemorrhage 2 75.00 Quite High
Substance Withdrawal Syndrome 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RATIONALE AND OBJECTIVES: We have recently reported that conditioned morphine reward and tolerance to its antinociceptive effect, but not expression of morphine dependence, were attenuated by 2-(phosphonomethyl)pentanedioic acid (2-PMPA), a prototypic inhibitor of glutamate carboxipeptidase II (GCP II), which is an enzyme responsible for the supply of glutamate.
Negative_regulation (inhibitor) of GCP II associated with addiction, glutamate, tolerance, antinociceptive and morphine
1) Confidence 0.38 Published 2005 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 16220328 Disease Relevance 0.10 Pain Relevance 0.85
In the present study, we investigated in more detail the effects of GCP II inhibition on opioid dependence and tolerance to its antinociceptive effect in C57/Bl mice using a novel GCP II inhibitor.
Negative_regulation (inhibitor) of GCP II associated with addiction, tolerance, antinociceptive and opioid
2) Confidence 0.28 Published 2005 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 16220328 Disease Relevance 0.18 Pain Relevance 0.81
In the present study, we investigated in more detail the effects of GCP II inhibition on opioid dependence and tolerance to its antinociceptive effect in C57/Bl mice using a novel GCP II inhibitor.
Spec (investigated) Negative_regulation (inhibition) of GCP II associated with addiction, tolerance, antinociceptive and opioid
3) Confidence 0.28 Published 2005 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 16220328 Disease Relevance 0.19 Pain Relevance 0.83
A new strategy for the treatment of neuronal injury involves inhibition of the neuropeptidase glutamate carboxypeptidase II (GCP II), also known as N-acetylated alpha-linked acidic dipeptidase.
Negative_regulation (inhibition) of GCP II in neuronal associated with glutamate and injury
4) Confidence 0.14 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16190866 Disease Relevance 0.36 Pain Relevance 0.41
Inhibition of glutamate carboxypeptidase II (GCP II; NAALADase) produces a variety of effects on glutamatergic neurotransmission.
Negative_regulation (Inhibition) of GCP II associated with glutamate
5) Confidence 0.12 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12629525 Disease Relevance 0.14 Pain Relevance 0.81
The aim of this study was to investigate effects of GCP II inhibition with the selective inhibitor, 2-PMPA, on: (a) development of tolerance to the antinociceptive effects, (b) withdrawal, and (c) conditioned reward produced by morphine in C57/Bl mice.
Spec (investigate) Negative_regulation (inhibition) of GCP II associated with tolerance, withdrawal, antinociceptive and morphine
6) Confidence 0.12 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12629525 Disease Relevance 0.15 Pain Relevance 1.03
These findings support the hypothesis that GCP II inhibitors may represent a novel treatment for peripheral neuropathies as well as stroke.
Negative_regulation (inhibitors) of GCP II associated with stroke and peripheral neuropathy
7) Confidence 0.10 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16190866 Disease Relevance 0.92 Pain Relevance 0.38

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