INT10916

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Context Info
Confidence 0.49
First Reported 1988
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 39
Total Number 39
Disease Relevance 25.88
Pain Relevance 5.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
PMNs 4
hepatocyte 1
spinal cord 1
brain 1
platelet 1
BDNF-AS (Homo sapiens)
Pain Link Frequency Relevance Heat
Codeine 2 100.00 Very High Very High Very High
Adalimumab 120 99.04 Very High Very High Very High
antagonist 12 98.76 Very High Very High Very High
Spinal cord 21 98.36 Very High Very High Very High
substance P 6 98.14 Very High Very High Very High
primary afferent fibers 2 98.06 Very High Very High Very High
peptic ulcer disease 1 97.92 Very High Very High Very High
headache 3 96.20 Very High Very High Very High
rheumatoid arthritis 310 95.68 Very High Very High Very High
Angina 9 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 119 100.00 Very High Very High Very High
Bacillus Anthracis Infection 10 100.00 Very High Very High Very High
Nephritis 51 99.96 Very High Very High Very High
Hepatitis 50 99.92 Very High Very High Very High
Cryoglobulinemia 1 99.80 Very High Very High Very High
Wheal 2 99.76 Very High Very High Very High
Autoimmune Disease 16 99.74 Very High Very High Very High
Leukopenia 1 99.58 Very High Very High Very High
Apoptosis 49 99.24 Very High Very High Very High
Infection 264 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that hundreds of different noncoding RNAs might be generated from the antiBDNF gene as a result of alternative splicing.
Positive_regulation (generated) of antiBDNF
1) Confidence 0.49 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.04
Our results show that the expression of antiBDNF and BDNF transcripts in different tissues is not mutually exclusive and that the levels of BDNF mRNA do not appear to be specifically reduced in tissues that express high levels of antiBDNF transcripts.
Positive_regulation (levels) of antiBDNF
2) Confidence 0.49 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.04
High levels of antiBDNF mRNAs are present in the brain, kidney, spinal cord, and testis.
Positive_regulation (levels) of antiBDNF in testis associated with spinal cord
3) Confidence 0.46 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.05
In silico and RT-PCR analyses showed that alternative splicing from the antiBDNF pre-mRNA produces more than 300 transcripts, but exon 1 of antiBDNF is always used as the most 5?
Positive_regulation (used) of antiBDNF
4) Confidence 0.43 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0
Tazifylline was associated (in atopics and non-atopics) with statistically significant dose related inhibitions, of flare over 5-15 mg and of wheal (10-15 mg) induced by the more potent and reproducible challenges of codeine, 1% histamine and anti-IgE.
Positive_regulation (induced) of anti-IgE associated with wheal and codeine
5) Confidence 0.34 Published 1988 Journal Arzneimittelforschung Section Abstract Doc Link 2897197 Disease Relevance 0.19 Pain Relevance 0.17
It's not clear why only the spleen was involved and why the anti-E. granulosus serum levels of were increased only a little.
Neg (little) Positive_regulation (increased) of anti-E in spleen
6) Confidence 0.34 Published 2004 Journal Parassitologia Section Abstract Doc Link 15305685 Disease Relevance 1.30 Pain Relevance 0.39
High levels of antiBDNF mRNAs are present in the brain, kidney, spinal cord, and testis.
Positive_regulation (levels) of antiBDNF in kidney associated with spinal cord
7) Confidence 0.16 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.05
High levels of antiBDNF mRNAs are present in the brain, kidney, spinal cord, and testis.
Positive_regulation (levels) of antiBDNF in spinal cord associated with spinal cord
8) Confidence 0.16 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.05
High levels of antiBDNF mRNAs are present in the brain, kidney, spinal cord, and testis.
Positive_regulation (levels) of antiBDNF in brain associated with spinal cord
9) Confidence 0.16 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.05
Thus, if anti-MCV levels increase by 1 unit, DAS28 score will rise 0.00075 points.
Positive_regulation (increase) of anti-MCV
10) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374444 Disease Relevance 0.20 Pain Relevance 0.07
can be multiplied by the increase in anti-MCV levels to calculate the increase in DAS28.
Positive_regulation (increase) of anti-MCV
11) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374444 Disease Relevance 0.28 Pain Relevance 0.11
Serology studies demonstrated increased anti-H. pylori antibody titers.
Positive_regulation (increased) of anti-H
12) Confidence 0.08 Published 1997 Journal J. Pediatr. Hematol. Oncol. Section Body Doc Link 9149750 Disease Relevance 0.17 Pain Relevance 0
Within such a contentious international context, a series of large observational studies conducted in Scotland in the mid-1990s compared prevalence of anti-HCV for the periods before during and after introduction of NEPs.
Positive_regulation (prevalence) of anti-HCV associated with hepatitis c virus infection
13) Confidence 0.06 Published 2006 Journal Harm Reduct J Section Body Doc Link PMC1569828 Disease Relevance 0.53 Pain Relevance 0.04
Our data showed that the anti-PA antibody response and the anthrax lethal toxin-neutralization activity induced by the nasal PA/LPD in non-anaesthetized mice was relatively weaker than that in anaesthetized mice.
Positive_regulation (induced) of anti-PA in nasal associated with bacillus anthracis infection
14) Confidence 0.05 Published 2006 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 16597361 Disease Relevance 0.59 Pain Relevance 0
Anti-hepatitis C (anti-HCV) was positive in one case (case 1), but HCV was not detected on polymerase chain reaction (PCR).
Positive_regulation (positive) of anti-HCV associated with hepatitis c virus infection and hepatitis
15) Confidence 0.03 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1797842 Disease Relevance 1.30 Pain Relevance 0.03
As regards anti-ENA autoantibodies, three patients were positive for anti-Ro (52 and 60 kDa) before adalimumab and two additional patients became positive during treatment.
Positive_regulation (positive) of anti-Ro associated with adalimumab
16) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.27 Pain Relevance 0.38
The occurrence of IgM anti-dsDNA autoantibodies was associated with the presence of IgG anti-dsDNA only in two patients at the 24th week and in four patients at the 48th week after treatment.
Positive_regulation (occurrence) of anti-dsDNA
17) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.15 Pain Relevance 0.35
A significant induction of antinuclear autoantibodies (ANA) and IgG/IgM anti-dsDNA autoantibodies were also found in 28% and 14.6% patients, respectively, whereas aCL and anti-?
Positive_regulation (induction) of anti-dsDNA
18) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526573 Disease Relevance 0.39 Pain Relevance 0.38
Rabbit derived antiserum dependent-reduction of circulating PMNs in the dog or using monoclonal antibody anti-CD11b/CD18 of PMNs resulted in smaller myocardial infarcts.
Positive_regulation (using) of anti-CD11b in PMNs associated with myocardial infarction
19) Confidence 0.02 Published 1991 Journal Atherosclerosis Section Abstract Doc Link 1811545 Disease Relevance 0.88 Pain Relevance 0.17
Rabbit derived antiserum dependent-reduction of circulating PMNs in the dog or using monoclonal antibody anti-CD11b/CD18 of PMNs resulted in smaller myocardial infarcts.
Positive_regulation (using) of anti-CD11b in PMNs associated with myocardial infarction
20) Confidence 0.02 Published 1991 Journal Atherosclerosis Section Abstract Doc Link 1811545 Disease Relevance 0.88 Pain Relevance 0.17

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