INT10917

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 16.39
Pain Relevance 6.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGAM) plasma membrane (ITGAM)
Anatomy Link Frequency
neutrophils 11
leukocytes 4
macrophages 2
monocytes 2
lymph node 1
ITGAM (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 17 99.76 Very High Very High Very High
Spinal cord 34 99.74 Very High Very High Very High
Inflammatory mediators 7 99.64 Very High Very High Very High
Opioid 7 99.08 Very High Very High Very High
cocaine 8 98.44 Very High Very High Very High
Inflammation 335 98.24 Very High Very High Very High
local anesthetic 16 98.16 Very High Very High Very High
substance P 6 97.94 Very High Very High Very High
Enkephalin 7 97.70 Very High Very High Very High
Angina 18 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 375 100.00 Very High Very High Very High
INFLAMMATION 411 99.64 Very High Very High Very High
Necrosis 16 99.56 Very High Very High Very High
Cancer 43 99.38 Very High Very High Very High
Sprains And Strains 86 99.32 Very High Very High Very High
Demyelinating Disease 229 99.00 Very High Very High Very High
Inflammatory Bowel Disease 27 98.58 Very High Very High Very High
Coronary Artery Disease 8 98.52 Very High Very High Very High
Disease 119 98.40 Very High Very High Very High
Brain Injury 218 98.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The findings demonstrate increases in plasma IL-8 and CD11b/CD18 as inflammatory mediators, vWF and CD41 as the abnormal coagulation activity may therefore yield a rationale for pharmacological anticytokines in patients with UA after coronary angioplasty.
Positive_regulation (increases) of CD11b in plasma associated with angina and inflammatory mediators
1) Confidence 0.67 Published 2002 Journal Jpn Heart J Section Abstract Doc Link 12025897 Disease Relevance 0.74 Pain Relevance 0.69
The cationic local anesthetic lidocaine inhibited not only FMLP-induced O2- release in neutrophils but also FMLP-induced CD11b upregulation and LAM-1 downregulation on neutrophils in a dose-dependent manner.
Positive_regulation (upregulation) of CD11b in neutrophils associated with lidocaine and local anesthetic
2) Confidence 0.56 Published 1994 Journal Exp. Hematol. Section Abstract Doc Link 7513653 Disease Relevance 0.24 Pain Relevance 0.66
We have shown that: (1) met-enkephalin and beta-endorphin at physiological concentrations relevant to that of in vivo (10(-8) and 10(-6) M) enhanced fMLP, PMA or OZ stimulated chemiluminescence and induced chemotactic response, (2) High concentrations of beta-endorphin (10(-3) M) or met-enkephalin (10(-5) M) decreased the CL response of PMN in vitro, (3) The opioid peptides at lower concentrations resulted in CD11b and CD18 molecule up-regulation on neutrophils.
Positive_regulation (up-regulation) of CD11b in neutrophils associated with enkephalin and opioid
3) Confidence 0.55 Published 1999 Journal Immunol. Lett. Section Abstract Doc Link 10232386 Disease Relevance 0 Pain Relevance 1.05
In contrast, the expression of other adhesion molecules by neutrophils was unaffected (CD11a, CD31, CD44) or slightly increased (CD11b).
Positive_regulation (increased) of CD11b in neutrophils
4) Confidence 0.51 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8730134 Disease Relevance 0.12 Pain Relevance 0
Correlation between CD11b/CD18 and increase of aggregability of granulocytes in coronary artery disease.
Positive_regulation (increase) of CD11b in coronary artery associated with coronary artery disease
5) Confidence 0.49 Published 1992 Journal Inflammation Section Title Doc Link 1526663 Disease Relevance 0.61 Pain Relevance 0.17
In the experimental control group, the total number of CD11b+ macrophages in the white pulp area was increased to 111,268,135.09±61,349,219.9, and the number of CD11b+-positive cells per unit volume was also increased to 428.8±241.01 cells/mm3 compared to the normal control group.
Positive_regulation (increased) of CD11b in macrophages
6) Confidence 0.49 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998779 Disease Relevance 0 Pain Relevance 0
Immunohistochemical data demonstrate that in DM- and NDM-strain-infected spinal cord there is an increase of LCA+/CD11b+ cells; however, the distribution of these inflammatory cells is significantly different between the two strains.

15.7.

Positive_regulation (increase) of CD11b in spinal cord associated with inflammation, sprains and strains, demyelinating disease and spinal cord
7) Confidence 0.49 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2905936 Disease Relevance 1.55 Pain Relevance 0.40
In the experimental control group, the total number of CD11b+ macrophages in the white pulp area was increased to 111,268,135.09±61,349,219.9, and the number of CD11b+-positive cells per unit volume was also increased to 428.8±241.01 cells/mm3 compared to the normal control group.
Positive_regulation (increased) of CD11b in macrophages
8) Confidence 0.49 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998779 Disease Relevance 0 Pain Relevance 0
The up-regulation of CD11b induced by platelet-activating factor (PAF) priming was also inhibited by ropivacaine. fMLP increased adhesion of neutrophils to HUVECs, which was inhibited by ropivacaine.
Positive_regulation (up-regulation) of CD11b in neutrophils associated with adhesions
9) Confidence 0.47 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.40 Pain Relevance 0.36
The up-regulation of CD11b induced by platelet-activating factor (PAF) priming was also inhibited by ropivacaine. fMLP increased adhesion of neutrophils to HUVECs, which was inhibited by ropivacaine.
Positive_regulation (induced) of CD11b in neutrophils associated with adhesions
10) Confidence 0.47 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.40 Pain Relevance 0.35
In the same region, persistent upregulation of NMDA receptor NR1 phosphorylation and protein expression and increased expression of glial markers glial fibrillary acidic protein (astroglia) and CD11b (microglia) were found.
Positive_regulation (upregulation) of CD11b in microglia
11) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link 20633279 Disease Relevance 0.16 Pain Relevance 0
In the active stage of the disease, the helper-inducer (CD4 + CD29+), activated T cell (CD4 + CD25+), and cytotoxic/NK (CD8 Dull + CD11b Bright+) subsets were increased compared with subsets in controls.
Positive_regulation (increased) of CD11b in T cell associated with disease
12) Confidence 0.45 Published 1997 Journal Rinsho Shinkeigaku Section Abstract Doc Link 9396360 Disease Relevance 1.32 Pain Relevance 0.14
Recombinant PSP/reg elicited a dose-dependent shedding of L-selectin (CD62L) and upregulation of beta2-integrin (CD11b) in neutrophils, which indicates that PSP/reg activates neutrophils.
Positive_regulation (upregulation) of CD11b in neutrophils
13) Confidence 0.43 Published 2009 Journal Crit. Care Med. Section Body Doc Link 19325491 Disease Relevance 0.11 Pain Relevance 0
Lidocaine also abolished the priming effect of rhG-CSF for enhanced release of O2- in neutrophils and inhibited rhG-CSF-induced CD11b upregulation and LAM-1 downregulation on neutrophils in a dose-dependent manner.
Positive_regulation (upregulation) of CD11b in neutrophils associated with lidocaine
14) Confidence 0.41 Published 1994 Journal Exp. Hematol. Section Abstract Doc Link 7513653 Disease Relevance 0.24 Pain Relevance 0.70
Results of this study show that leukocytes from TBI patients resuscitated with NS display rapid induction of constitutively expressed CD62L and activation of CD11b with translocation to the cell membrane from intracellular secretory granules [31].
Positive_regulation (activation) of CD11b in leukocytes associated with brain injury
15) Confidence 0.35 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 1.04 Pain Relevance 0.14
Moreover, ropivacaine inhibited the tumor necrosis factor alpha-induced up-regulation of CD11b/CD18 and L-selectin shedding by human leukocytes in vitro.
Positive_regulation (up-regulation) of CD11b/CD18 in leukocytes associated with necrosis and cancer
16) Confidence 0.33 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9336308 Disease Relevance 0.86 Pain Relevance 0.16
RESULTS: Indomethacin caused a concentration- and time-dependent upregulation of CD11b and CD18 expression and PMN adhesion to endothelial cells.
Positive_regulation (upregulation) of CD11b in PMN
17) Confidence 0.30 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
However, CD11b was not increased on the surface of freshly isolated monocytes.
Neg (not) Positive_regulation (increased) of CD11b in monocytes
18) Confidence 0.25 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.19 Pain Relevance 0.08
However, CD11b was not increased on the surface of freshly isolated monocytes.
Positive_regulation (increased) of CD11b in monocytes
19) Confidence 0.25 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.19 Pain Relevance 0.08
Moreover, ropivacaine inhibited the tumor necrosis factor alpha-induced up-regulation of CD11b/CD18 and L-selectin shedding by human leukocytes in vitro.
Positive_regulation (up-regulation) of CD11b/CD18 in leukocytes associated with necrosis and cancer
20) Confidence 0.24 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9336308 Disease Relevance 0.86 Pain Relevance 0.16

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