INT10918

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Context Info
Confidence 0.76
First Reported 1990
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 93
Total Number 94
Disease Relevance 71.80
Pain Relevance 16.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGB2) plasma membrane (ITGB2) cell-cell signaling (ITGB2)
Anatomy Link Frequency
neutrophils 33
monocytes 8
leukocytes 7
granulocytes 5
plasma 4
ITGB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 157 100.00 Very High Very High Very High
agonist 51 100.00 Very High Very High Very High
chemokine 34 100.00 Very High Very High Very High
Morphine 5 99.80 Very High Very High Very High
Angina 105 99.68 Very High Very High Very High
Enkephalin 16 99.64 Very High Very High Very High
rheumatoid arthritis 60 99.60 Very High Very High Very High
lidocaine 26 99.58 Very High Very High Very High
Opioid 23 99.46 Very High Very High Very High
Fibrositis 14 99.14 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nicotine Addiction 3420 100.00 Very High Very High Very High
Adhesions 1895 100.00 Very High Very High Very High
Cancer 234 100.00 Very High Very High Very High
Airway Obstruction 40 100.00 Very High Very High Very High
Necrosis 14 100.00 Very High Very High Very High
Wound Healing 19 99.80 Very High Very High Very High
Cv General 3 Under Development 92 99.68 Very High Very High Very High
Rheumatoid Arthritis 60 99.60 Very High Very High Very High
Epilepsy 1 99.38 Very High Very High Very High
Stress 22 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neutrophil CD18 expression on exposure to hypoxia-reoxygenation was less in lidocaine (0.005 mg mL(-1)) treated cells compared to control (71.07+/-10.14 vs. 109.84+/-35.44 MCF, P = 0.03).
Gene_expression (expression) of CD18 in Neutrophil
1) Confidence 0.76 Published 2004 Journal Eur J Anaesthesiol Section Body Doc Link 15719860 Disease Relevance 0.19 Pain Relevance 0
The effect of lidocaine on neutrophil CD11b/CD18 and endothelial ICAM-1 expression and IL-1beta concentrations induced by hypoxia-reoxygenation.
Gene_expression (expression) of CD18 in neutrophil associated with hypoxia and lidocaine
2) Confidence 0.76 Published 2004 Journal Eur J Anaesthesiol Section Title Doc Link 15719860 Disease Relevance 0.10 Pain Relevance 0.20
RESULTS: Exposure to hypoxia-reoxygenation increased neutrophil CD11b (94.33+/-40.65 vs. 34.32+/-6.83 mean channel fluorescence (MCF), P = 0.02), CD18 (109.84+/-35.44 vs. 59.05+/-6.71 MCF, P = 0.03) and endothelial ICAM-1 (146.62+/-16.78 vs. 47.29+/-9.85 MCF, P < 0.001) expression compared to normoxia.
Gene_expression (expression) of CD18 in neutrophil
3) Confidence 0.76 Published 2004 Journal Eur J Anaesthesiol Section Body Doc Link 15719860 Disease Relevance 0.21 Pain Relevance 0
CONCLUSIONS: Lidocaine at clinically relevant concentrations decreased neutrophil CD18 and endothelial ICAM-1 expression but not endothelial IL-1beta concentrations.


Gene_expression (expression) of CD18 in neutrophil
4) Confidence 0.76 Published 2004 Journal Eur J Anaesthesiol Section Body Doc Link 15719860 Disease Relevance 0 Pain Relevance 0
Ionomycin and thapsigargin caused a 7-10-fold increase in [Ca2+]i and a 2-4-fold increase in Mac-1 expression.
Gene_expression (expression) of Mac-1
5) Confidence 0.75 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
Tyrosine kinase inhibitors prevented the effect of indomethacin on Mac-1 expression and Ca2+ mobilization.
Gene_expression (expression) of Mac-1
6) Confidence 0.75 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
RESULTS: Indomethacin caused a concentration- and time-dependent upregulation of CD11b and CD18 expression and PMN adhesion to endothelial cells.
Gene_expression (expression) of CD18 in PMN
7) Confidence 0.75 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
[Ca2+]i was measured in PMN loaded with fura-2 and Mac-1 expression by flow cytometry.
Gene_expression (expression) of Mac-1 in PMN
8) Confidence 0.75 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
Maximal upregulation of Mac-1 expression (40-50%) occurred after a 30-min incubation with 0.1mM indomethacin.
Gene_expression (expression) of Mac-1
9) Confidence 0.75 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
We found that coronary angioplasty with stent implantation produces an increase in the cell surface expression of CD11b/CD18 in neutrophils and CD38 in monocytes, following a similar time-course with a peak after 24 h, returning to basal levels after 48 h and a second peak after 7 days.
Gene_expression (expression) of CD18 in neutrophils
10) Confidence 0.75 Published 2004 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 15080559 Disease Relevance 0.30 Pain Relevance 0.26
Because stress is known to modulate adhesion molecule expression, we determined L: -selectin (CD62L) and beta(2)-integrin (CD11b/CD18) expression on the surface of polymorphonuclear leukocytes in 22 patients with FM.
Gene_expression (expression) of CD18 in polymorphonuclear leukocytes associated with stress, fibrositis and adhesions
11) Confidence 0.75 Published 2009 Journal Rheumatol. Int. Section Abstract Doc Link 19052753 Disease Relevance 0.81 Pain Relevance 0.37
As compared to age and sex-matched healthy controls, FM patients showed a significantly decreased expression of CD62L (p < 0.01) and CD11b/CD18 (p < 0.05) on polymorphonuclear leukocytes.
Gene_expression (expression) of CD18 in polymorphonuclear leukocytes associated with fibrositis
12) Confidence 0.75 Published 2009 Journal Rheumatol. Int. Section Abstract Doc Link 19052753 Disease Relevance 0.78 Pain Relevance 0.39
The naloxone-sensitive impairment by morphine of CD11b-CD18 complex surface expression observed could play a role in opioid inhibition of granulocyte activation.
Gene_expression (expression) of CD18 in granulocyte associated with narcan, opioid and morphine
13) Confidence 0.75 Published 1990 Journal Inflammation Section Abstract Doc Link 1982531 Disease Relevance 0.07 Pain Relevance 1.04
RESULTS: In 38 patients with unstable angina, neutrophils and monocytes showed a significantly higher expression of CD11b/CD18 adhesion receptors in coronary sinus than aortic blood (p < 0.0001 and p < 0.001, respectively).
Gene_expression (expression) of CD18 in monocytes
14) Confidence 0.75 Published 1995 Journal J. Am. Coll. Cardiol. Section Body Doc Link 7594025 Disease Relevance 0 Pain Relevance 0
The peak plasma levels of IL-8 (172.24 +/- 37.82 pg/mL at 12 hours) and vWF (256 +/- 42.32% at 4 hours) significantly increased after coronary angioplasty (both p < 0.01), and were associated with significant time course increases in surface expression of CD11b/CD18 (p < 0.01) and CD41 (p < 0.01).
Gene_expression (expression) of CD18 in plasma
15) Confidence 0.75 Published 2002 Journal Jpn Heart J Section Abstract Doc Link 12025897 Disease Relevance 0.97 Pain Relevance 0.94
Expression of CD11b/CD18 on granulocytes and monocytes and CD41 on platelets was measured by flow cytometry.
Gene_expression (Expression) of CD18 in monocytes
16) Confidence 0.75 Published 2006 Journal Int Angiol Section Body Doc Link 16878082 Disease Relevance 0.08 Pain Relevance 0
Polymorphonuclear (PMN) of H and M subjects also exhibited a very marked and similar reduction in the expression of CD11b/CD18 integrin receptors after fMLP treatment, with values that were less than 10% of those in controls, as observed by flow cytometry.
Gene_expression (expression) of CD18
17) Confidence 0.75 Published 1994 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 7868301 Disease Relevance 0.30 Pain Relevance 0.47
All nonsteroidal antiinflammatory drugs (NSAIDs) inhibit neutrophil aggregation (homotypic cell-cell adhesion) and do so without affecting expression of CD11b/CD18.
Gene_expression (expression) of CD18 in neutrophil associated with inflammation, cinod and adhesions
18) Confidence 0.75 Published 1994 Journal Inflammation Section Abstract Doc Link 8088928 Disease Relevance 0.61 Pain Relevance 0.35
PMNs of E and M subjects also exhibited a very marked and similar reduction in the expression of CD11b/CD18 integrin receptors after fMLP treatment with values that were lower than 10% of those in controls as observed by flow cytometry.
Gene_expression (expression) of CD18
19) Confidence 0.75 Published 1996 Journal Recenti Prog Med Section Abstract Doc Link 9122534 Disease Relevance 0.31 Pain Relevance 0.40
NF-kappaB activation, CD11b/CD18 expression, and the production of TNF-alpha, IL-8, and IL-6 in monocytes and granulocytes were inhibited by NCR in vitro.
Gene_expression (expression) of CD18 in granulocytes
20) Confidence 0.75 Published 2005 Journal Shock Section Abstract Doc Link 16044078 Disease Relevance 0.37 Pain Relevance 0.35

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