INT10919

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 25
Total Number 26
Disease Relevance 13.75
Pain Relevance 5.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGB2) plasma membrane (ITGB2) cell-cell signaling (ITGB2)
Anatomy Link Frequency
neutrophils 5
eosinophils 2
PMNs 2
monocyte 2
LGN 2
ITGB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 70 100.00 Very High Very High Very High
chemokine 7 100.00 Very High Very High Very High
Inflammatory mediators 1 99.84 Very High Very High Very High
Substantia nigra 49 99.76 Very High Very High Very High
Opioid 7 98.88 Very High Very High Very High
cytokine 112 98.56 Very High Very High Very High
cocaine 8 98.44 Very High Very High Very High
cINOD 12 98.36 Very High Very High Very High
Neuritis 2 97.52 Very High Very High Very High
Enkephalin 6 97.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 106 100.00 Very High Very High Very High
Adhesions 50 100.00 Very High Very High Very High
Ocular Hypertension 142 99.52 Very High Very High Very High
Asthma 50 99.04 Very High Very High Very High
Syndrome 4 98.88 Very High Very High Very High
Myocardial Infarction 12 98.84 Very High Very High Very High
Coronary Artery Disease 12 98.52 Very High Very High Very High
Optic Nerve Injuries 70 98.24 Very High Very High Very High
Experimental Autoimmune Neuritis 2 97.52 Very High Very High Very High
Injury 25 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indomethacin-induced Mac-1 upregulation was prevented by a nitric oxide synthase inhibitor.
Positive_regulation (upregulation) of Mac-1
1) Confidence 0.67 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Indomethacin-induced upregulation of Mac-1 is mediated by changes in [Ca2+]i and nitric oxide.
Positive_regulation (upregulation) of Mac-1
2) Confidence 0.67 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
We have shown that: (1) met-enkephalin and beta-endorphin at physiological concentrations relevant to that of in vivo (10(-8) and 10(-6) M) enhanced fMLP, PMA or OZ stimulated chemiluminescence and induced chemotactic response, (2) High concentrations of beta-endorphin (10(-3) M) or met-enkephalin (10(-5) M) decreased the CL response of PMN in vitro, (3) The opioid peptides at lower concentrations resulted in CD11b and CD18 molecule up-regulation on neutrophils.
Positive_regulation (up-regulation) of CD18 in neutrophils associated with enkephalin and opioid
3) Confidence 0.57 Published 1999 Journal Immunol. Lett. Section Abstract Doc Link 10232386 Disease Relevance 0 Pain Relevance 1.05
The findings demonstrate increases in plasma IL-8 and CD11b/CD18 as inflammatory mediators, vWF and CD41 as the abnormal coagulation activity may therefore yield a rationale for pharmacological anticytokines in patients with UA after coronary angioplasty.
Positive_regulation (increases) of CD18 in plasma associated with angina and inflammatory mediators
4) Confidence 0.45 Published 2002 Journal Jpn Heart J Section Abstract Doc Link 12025897 Disease Relevance 0.74 Pain Relevance 0.69
We described previously that expression levels of the chemokine receptor, CCR5, and the beta2-integrin, Mac-1, were down-regulated on primary monocytes after incubation in supernatants from human carcinoma cell lines, and that this down-regulation resulted in impaired monocyte function with respect to migration and adhesion.
Positive_regulation (levels) of beta2-integrin in monocyte associated with chemokine, carcinoma and adhesions
5) Confidence 0.40 Published 2003 Journal FASEB J. Section Abstract Doc Link 12490541 Disease Relevance 0.48 Pain Relevance 0.14
We described previously that expression levels of the chemokine receptor, CCR5, and the beta2-integrin, Mac-1, were down-regulated on primary monocytes after incubation in supernatants from human carcinoma cell lines, and that this down-regulation resulted in impaired monocyte function with respect to migration and adhesion.
Positive_regulation (levels) of Mac-1 in monocyte associated with chemokine, carcinoma and adhesions
6) Confidence 0.40 Published 2003 Journal FASEB J. Section Abstract Doc Link 12490541 Disease Relevance 0.49 Pain Relevance 0.14
NPC 15669 inhibited eosinophil chemotaxis in vitro at a drug concentration of 10(-5) M (mean inhibition, 48.2%) without affecting Mac-1 receptor upregulation on stimulated eosinophils.
Positive_regulation (upregulation) of Mac-1 receptor in eosinophils
7) Confidence 0.29 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943251 Disease Relevance 0.34 Pain Relevance 0.12
E-selectin, an adhesion molecule classically upregulated during inflammation, as well as Mac-1, a ligand for ICAM-1, were not expressed on human Schwann cells at basal condition or after treatment with cytokines.
Positive_regulation (upregulated) of Mac-1 in Schwann cells associated with inflammation, adhesions and cytokine
8) Confidence 0.26 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10561528 Disease Relevance 0.71 Pain Relevance 0.37
We investigated the induction of adhesion molecules such as L-selectin, E-selectin, ICAM-1, VCAM-1 and Mac-1 on Schwann cells by proinflammatory cytokines.
Spec (investigated) Positive_regulation (induction) of Mac-1 in Schwann cells associated with adhesions and cytokine
9) Confidence 0.26 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10561528 Disease Relevance 0.56 Pain Relevance 0.32
RESULTS: Indomethacin caused a concentration- and time-dependent upregulation of CD11b and CD18 expression and PMN adhesion to endothelial cells.
Positive_regulation (upregulation) of CD18 in PMN
10) Confidence 0.21 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
Cocaine and its derivatives blunted responses of neutrophils (cell/cell aggregation, up-regulation of the receptor for C3bi (CR3, CD11b/CD18), generation of superoxide anion (O2-) and degranulation to various stimuli.
Positive_regulation (up-regulation) of CD18 in neutrophils associated with cocaine
11) Confidence 0.21 Published 1990 Journal J. Immunol. Section Abstract Doc Link 2161879 Disease Relevance 0 Pain Relevance 0.51
Correlation between CD11b/CD18 and increase of aggregability of granulocytes in coronary artery disease.
Positive_regulation (increase) of CD18 in coronary artery associated with coronary artery disease
12) Confidence 0.21 Published 1992 Journal Inflammation Section Title Doc Link 1526663 Disease Relevance 0.61 Pain Relevance 0.17
Rabbit-derived antiserum-dependent reduction of circulating PMNs in the dog or using monoclonal antibody anti-CD11b/CD18 of PMNs resulted in smaller myocardial infarcts.
Positive_regulation (using) of CD18 in PMNs associated with myocardial infarction
13) Confidence 0.21 Published 1992 Journal Inflammation Section Abstract Doc Link 1526663 Disease Relevance 0.63 Pain Relevance 0.18
We studied the effects of NPC 15669, a member of a new class of anti-inflammatory drugs called leumedins, on chemotaxis of both human eosinophils and neutrophils and on Mac-1 receptor upregulation on stimulated eosinophils in vitro.
Positive_regulation (upregulation) of Mac-1 receptor in eosinophils associated with inflammation and cinod
14) Confidence 0.21 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943251 Disease Relevance 0.31 Pain Relevance 0.14
On the contrary, neutrophils exposed to leptin did not display detectable [Ca2+]i mobilization, oxidant production, or beta2-integrin upregulation [46].
Positive_regulation (upregulation) of beta2-integrin in neutrophils
15) Confidence 0.15 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.28 Pain Relevance 0.08
Rabbit derived antiserum dependent-reduction of circulating PMNs in the dog or using monoclonal antibody anti-CD11b/CD18 of PMNs resulted in smaller myocardial infarcts.
Positive_regulation (using) of CD18 in PMNs associated with myocardial infarction
16) Confidence 0.12 Published 1991 Journal Atherosclerosis Section Abstract Doc Link 1811545 Disease Relevance 0.88 Pain Relevance 0.17
Furthermore, it appears that the interaction between phagocytes and surface P1/P2 epitope is via the Mac-1 (CD11b/CD18) integrin, which is upregulated on inflammatory cells recruited to the site of the implant [21,22].
Positive_regulation (upregulated) of Mac-1 in phagocytes associated with inflammation
17) Confidence 0.09 Published 2007 Journal J Transl Med Section Body Doc Link PMC1929055 Disease Relevance 0.48 Pain Relevance 0.19
Lidocaine reduces PMN adhesion to endothelial surfaces in vivo, and inhibits upregulation of PMN-CD11b/CD18 (Mac-1) in vitro.
Positive_regulation (upregulation) of CD18 associated with adhesions
18) Confidence 0.08 Published 1996 Journal Ann. Thorac. Surg. Section Abstract Doc Link 8619724 Disease Relevance 0.36 Pain Relevance 0.27
Expression of uPAR correlated with activation of beta(2)-integrins lymphocyte function-associated antigen 1 (LFA-1) and macrophage antigen 1 (Mac-1), measured by using monoclonal antibodies (mAbs) 24 and CBRM1/5.
Positive_regulation (activation) of Mac-1 in lymphocyte
19) Confidence 0.07 Published 2002 Journal Blood Section Abstract Doc Link 12393744 Disease Relevance 1.03 Pain Relevance 0.10
In the OHT animals, GFAP, but not MAC-1, immunoreactivity was elevated in spatial register with the treated eye layers of LGN and V1.
Positive_regulation (elevated) of MAC-1 in LGN associated with ocular hypertension
20) Confidence 0.07 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2773743 Disease Relevance 1.33 Pain Relevance 0.10

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